MT1F

MT1F
Identifiers
Aliases	MT1F , MT1, metallothionein 1F
External IDs	OMIM: 156352 HomoloGene: 136799 GeneCards: MT1F
Gene location (Human)
Chr.	Chromosome 16 (human)
End	56,660,698 bp
RNA expression pattern
	Top expressed in
	kidney tubule; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; glomerulus; ; metanephric glomerulus; ; kidney; ; right lobe of liver; ; internal globus pallidus; ; external globus pallidus; ; substantia nigra;
	n/a
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	zinc ion binding ; protein binding ; metal ion binding ;
Cellular component	cytoplasm ; perinuclear region of cytoplasm ; nucleus ;
Biological process	negative regulation of growth ; cellular response to cadmium ion ; cellular response to zinc ion ; cellular zinc ion homeostasis ; detoxification of copper ion ; cellular response to copper ion ;
	Sources:Amigo / QuickGO
Orthologs
	4494
	n/a
	ENSG00000198417
	n/a
	P04733
	n/a
	NM_005949 ; NM_001301272
	n/a
	NP_001288201 ; NP_005940
	n/a
	Wikidata
View/Edit Human

Last updated December 28, 2023

Metallothionein-1F is a protein that in humans is encoded by the MT1F gene.^[3]^[4]^[5]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198417 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A. 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi: 10.1073/pnas.81.17.5494 . PMC 391732 . PMID 6089206.
↑ Schmidt CJ, Jubier MF, Hamer DH (Jul 1985). "Structure and expression of two human metallothionein-I isoform genes and a related pseudogene". J Biol Chem. 260 (12): 7731–7. doi: 10.1016/S0021-9258(17)39668-0 . PMID 2581970.
↑ "Entrez Gene: MT1F metallothionein 1F".

West AK, Stallings R, Hildebrand CE, et al. (1991). "Human metallothionein genes: structure of the functional locus at 16q13". Genomics. 8 (3): 513–8. doi:10.1016/0888-7543(90)90038-V. PMID 2286373.
Gedamu L, Varshney U, Jahroudi N, et al. (1987). "Structure and expression of the human metallothionein genes". Metallothionein II. Experientia Supplementum. Vol. 52. pp. 361–72. doi:10.1007/978-3-0348-6784-9_34. ISBN 978-3-0348-6786-3. PMID 2444457.
Varshney U, Jahroudi N, Foster R, Gedamu L (1987). "Structure, organization, and regulation of human metallothionein IF gene: differential and cell-type-specific expression in response to heavy metals and glucocorticoids". Mol. Cell. Biol. 6 (1): 26–37. doi:10.1128/MCB.6.1.26. PMC 367480 . PMID 3023827.
Foster R, Jahroudi N, Varshney U, Gedamu L (1988). "Structure and expression of the human metallothionein-IG gene Differential promoter activity of two linked metallothionein-I genes in response to heavy metals". J. Biol. Chem. 263 (23): 11528–35. doi: 10.1016/S0021-9258(18)37990-0 . PMID 3403543.
Carter AD, Felber BK, Walling MJ, et al. (1985). "Duplicated heavy metal control sequences of the mouse metallothionein-I gene". Proc. Natl. Acad. Sci. U.S.A. 81 (23): 7392–6. doi: 10.1073/pnas.81.23.7392 . PMC 392152 . PMID 6095291.
Bylander JE, Li SL, Sens MA, Sens DA (1995). "Exposure of human proximal tubule cells to cytotoxic levels of CdCl2 induces the additional expression of metallothionein 1A mRNA". Toxicol. Lett. 76 (3): 209–17. doi:10.1016/0378-4274(95)80005-X. PMID 7762008.
Mididoddi S, McGuirt JP, Sens MA, et al. (1996). "Isoform-specific expression of metallothionein mRNA in the developing and adult human kidney". Toxicol. Lett. 85 (1): 17–27. doi:10.1016/0378-4274(96)03632-6. PMID 8619255.
Garrett SH, Somji S, Todd JH, et al. (1999). "Differential expression of human metallothionein isoform I mRNA in human proximal tubule cells exposed to metals". Environ. Health Perspect. 106 (12): 825–32. doi:10.2307/3434126. JSTOR 3434126. PMC 1533231 . PMID 9831543.
Vandeghinste N, Proost P, De Ley M (2000). "Metallothionein isoform gene expression in zinc-treated human peripheral blood lymphocytes". Cell. Mol. Biol. (Noisy-le-grand). 46 (2): 419–33. PMID 10774930.
Rahman MT, De Ley M (2001). "Metallothionein isogene transcription in red blood cell precursors from human cord blood". Eur. J. Biochem. 268 (3): 849–56. doi:10.1046/j.1432-1327.2001.01947.x. PMID 11168427.
Jin R, Bay BH, Chow VT, et al. (2001). "Significance of metallothionein expression in breast myoepithelial cells". Cell Tissue Res. 303 (2): 221–6. doi:10.1007/s004410000310. PMID 11291768. S2CID 6541195.
Garrett SH, Belcastro M, Sens MA, et al. (2001). "Acute exposure to arsenite induces metallothionein isoform-specific gene expression in human proximal tubule cells". J. Toxicol. Environ. Health A. 64 (4): 343–55. Bibcode:2001JTEHA..64..343G. doi:10.1080/152873901316981321. PMID 11693492. S2CID 43143430.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Izmailova E, Bertley FM, Huang Q, et al. (2003). "HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages". Nat. Med. 9 (2): 191–7. doi:10.1038/nm822. PMID 12539042. S2CID 26145639.
Lu DD, Chen YC, Zhang XR, et al. (2005). "The relationship between metallothionein-1F (MT1F) gene and hepatocellular carcinoma". The Yale Journal of Biology and Medicine. 76 (2): 55–62. PMC 2582696 . PMID 15369632.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967. S2CID 9746088.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198417 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid6089206-3] Karin M, Eddy RL, Henry WM, Haley LL, Byers MG, Shows TB (Oct 1984). "Human metallothionein genes are clustered on chromosome 16". Proc Natl Acad Sci U S A. 81 (17): 5494–8. Bibcode:1984PNAS...81.5494K. doi: 10.1073/pnas.81.17.5494 . PMC 391732 . PMID 6089206.

[pmid2581970-4] Schmidt CJ, Jubier MF, Hamer DH (Jul 1985). "Structure and expression of two human metallothionein-I isoform genes and a related pseudogene". J Biol Chem. 260 (12): 7731–7. doi: 10.1016/S0021-9258(17)39668-0 . PMID 2581970.

[entrez-5] "Entrez Gene: MT1F metallothionein 1F".

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MT1F

Related Research Articles

References

Further reading