MTCH2

MTCH2
Identifiers
Aliases	MTCH2 , MIMP, SLC25A50, HSPC032, mitochondrial carrier 2
External IDs	OMIM: 613221; MGI: 1929260; HomoloGene: 8645; GeneCards: MTCH2; OMA:MTCH2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p11.2 Start 47,617,315 bp [1] End 47,642,607 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 E1 Start 90,677,499 bp [2] End 90,697,154 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis mucosa of transverse colon rectum right lobe of liver duodenum stromal cell of endometrium islet of Langerhans gastrocnemius muscle human kidney Top expressed in spermatid spermatocyte testicle duodenum jejunum colon right kidney proximal tubule ileum white adipose tissue More reference expression data BioGPS n/a
Orthologs Species Human Mouse Entrez 23788 56428 Ensembl ENSG00000109919 ENSG00000285121 ENSMUSG00000027282 UniProt Q9Y6C9 Q791V5 RefSeq (mRNA) NM_014342 NM_001317231 NM_001317232 NM_001317233 NM_019758 NM_001317241 NM_001317242 NM_001317243 NM_001317244 RefSeq (protein) NP_001304160 NP_001304161 NP_001304162 NP_055157 NP_001304170 NP_001304171 NP_001304172 NP_001304173 NP_062732 Location (UCSC) Chr 11: 47.62 – 47.64 Mb Chr 2: 90.68 – 90.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mitochondrial carrier homolog 2 also known as MTCH2 is a protein which in humans is encoded by the MTCH2 gene. ^{[5] [6] [7] [8]}

MTCH2 resides on the outer mitochondrial membrane where it co-localizes with the apoptotic Bcl-2 family protein BID. ^[9]

Clinical significance

MTCH2 assists in the recruitment of BID into the mitochondria during apoptosis. ^[9]

Variants of the MTCH2 gene may be associated with obesity. ^[10] MTCH2 represses mitochondrial metabolism such that a deficiency of MTCH2 increases energy consumption and production by mitochondria. ^[9]

See also

• Mitochondrial carrier

References

1. ENSG00000285121 GRCh38: Ensembl release 89: ENSG00000109919, ENSG00000285121 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027282 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Grinberg M, Schwarz M, Zaltsman Y, Eini T, Niv H, Pietrokovski S, Gross A (June 2005). "Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha". Molecular and Cellular Biology. 25 (11): 4579–90. doi:10.1128/MCB.25.11.4579-4590.2005. PMC   1140633 . PMID   15899861.
6. Gross A (June 2005). "Mitochondrial carrier homolog 2: a clue to cracking the BCL-2 family riddle?". Journal of Bioenergetics and Biomembranes. 37 (3): 113–9. doi:10.1007/s10863-005-6222-3. PMID   16167168. S2CID   2395673.
7. Schwarz M, Andrade-Navarro MA, Gross A (May 2007). "Mitochondrial carriers and pores: key regulators of the mitochondrial apoptotic program?". Apoptosis. 12 (5): 869–76. doi: 10.1007/s10495-007-0748-2 . PMID   17453157.
8. Yu K, Ganesan K, Tan LK, Laban M, Wu J, Zhao XD, et al. (July 2008). Chang HY (ed.). "A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers". PLOS Genetics. 4 (7) e1000129. doi: 10.1371/journal.pgen.1000129 . PMC   2444049 . PMID   18636107.
9. Gross A (August 2016). "BCL-2 family proteins as regulators of mitochondria metabolism". Biochimica et Biophysica Acta (BBA) - Bioenergetics. 1857 (8): 1243–1246. doi: 10.1016/j.bbabio.2016.01.017 . PMID   26827940.
10. Renström F, Payne F, Nordström A, Brito EC, Rolandsson O, Hallmans G, et al. (April 2009). "Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden". Human Molecular Genetics. 18 (8): 1489–96. doi:10.1093/hmg/ddp041. PMC   2664142 . PMID   19164386.

Further reading

• Yerushalmi GM, Leibowitz-Amit R, Shaharabany M, Tsarfaty I (2002). "Met-HGF/SF signal transduction induces mimp, a novel mitochondrial carrier homologue, which leads to mitochondrial depolarization". Neoplasia. 4 (6): 510–22. doi:10.1038/sj.neo.7900272. PMC   1503665 . PMID   12407445.
• Haupt A, Thamer C, Heni M, Machicao F, Machann J, Schick F, et al. (June 2010). "Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study". Obesity. 18 (6): 1212–7. doi: 10.1038/oby.2009.413 . PMID   19910938. S2CID   9601431.
• Albers M, Kranz H, Kober I, Kaiser C, Klink M, Suckow J, et al. (February 2005). "Automated yeast two-hybrid screening for nuclear receptor-interacting proteins". Molecular & Cellular Proteomics. 4 (2): 205–13. doi: 10.1074/mcp.M400169-MCP200 . PMID   15604093.
• Li S, Zhao JH, Luan J, Luben RN, Rodwell SA, Khaw KT, et al. (January 2010). "Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies". The American Journal of Clinical Nutrition. 91 (1): 184–90. doi: 10.3945/ajcn.2009.28403 . PMID   19812171.
• Brandys MK, van Elburg AA, Loos RJ, Bauer F, Hendriks J, van der Schouw YT, Adan RA (March 2010). "Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa?". American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics. 153B (2): 695–699. doi:10.1002/ajmg.b.31026. PMID   19746409. S2CID   45793585.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (October 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Research. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Bauer F, Elbers CC, Adan RA, Loos RJ, Onland-Moret NC, Grobbee DE, et al. (October 2009). "Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference". The American Journal of Clinical Nutrition. 90 (4): 951–9. doi: 10.3945/ajcn.2009.27781 . PMID   19692490.
• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• He M, Cornelis MC, Franks PW, Zhang C, Hu FB, Qi L (February 2010). "Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus". Arteriosclerosis, Thrombosis, and Vascular Biology. 30 (2): 327–32. doi:10.1161/ATVBAHA.109.196196. PMC   3061473 . PMID   19910641.
• Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, Kamohara S, et al. (December 2009). "Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population". Journal of Human Genetics. 54 (12): 727–31. doi: 10.1038/jhg.2009.106 . PMID   19851340.