MTCP1

MTCP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A1X, 1QTT, 1QTU
Identifiers
Aliases	MTCP1 , P13p8mature T-cell proliferation 1, mature T cell proliferation 1, TCL1C
External IDs	OMIM: 300116; MGI: 102699; HomoloGene: 82921; GeneCards: MTCP1; OMA:MTCP1 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq28 Start 155,064,034 bp [1] End 155,147,937 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X A7.3 Start 74,454,050 bp [2] End 74,460,194 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle body of pancreas right testis right adrenal gland left testis left adrenal cortex right adrenal cortex left ovary right ovary gastric mucosa Top expressed in saccule otic placode otic vesicle Rostral migratory stream right kidney neural layer of retina ventricular zone tail of embryo embryo embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase binding protein serine/threonine kinase activator activity Cellular component protein-containing complex Biological process cell population proliferation positive regulation of peptidyl-serine phosphorylation positive regulation of protein serine/threonine kinase activity positive regulation of cell population proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4515 17763 Ensembl ENSG00000214827 ENSMUSG00000031200 UniProt P56278 Q61908 Q60945 RefSeq (mRNA) NM_014221 NM_001018025 NM_001039373 RefSeq (protein) NP_001018025 NP_001281206 NP_034969 NP_001034462 Location (UCSC) Chr X: 155.06 – 155.15 Mb Chr X: 74.45 – 74.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein p13 MTCP-1 is a protein that in humans is encoded by the MTCP1 gene. ^{[5] [6] [7] [8]}

Function

This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. The gene has two ORFs that encode two different proteins. The upstream ORF encodes a 13kDa protein that is a member of the TCL1 family; this protein may be involved in leukemogenesis. The downstream ORF encodes an 8kDa protein that localizes to mitochondria. Alternative splicing results in multiple transcript variants. ^[8]

Interactions

MTCP1 has been shown to interact with AKT1. ^{[9] [10]}

References

1. GRCh38: Ensembl release 89: ENSG00000214827 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031200 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stern MH, Soulier J, Rosenzwajg M, Nakahara K, Canki-Klain N, Aurias A, Sigaux F, Kirsch IR (September 1993). "MTCP-1: a novel gene on the human chromosome Xq28 translocated to the T cell receptor alpha/delta locus in mature T cell proliferations". Oncogene. 8 (9): 2475–83. PMID   8361760.
6. Madani A, Choukroun V, Soulier J, Cacheux V, Claisse JF, Valensi F, Daliphard S, Cazin B, Levy V, Leblond V, Daniel MT, Sigaux F, Stern MH (July 1996). "Expression of p13MTCP1 is restricted to mature T-cell proliferations with t(X;14) translocations". Blood. 87 (5): 1923–7. doi: 10.1182/blood.V87.5.1923.1923 . PMID   8634440.
7. Yang YS, Guignard L, Padilla A, Hoh F, Strub MP, Stern MH, Lhoste JM, Roumestand C (September 1998). "Solution structure of the recombinant human oncoprotein p13MTCP1". J Biomol NMR. 11 (3): 337–54. doi:10.1023/A:1008279616063. PMID   9691281. S2CID   22862333.
8. "Entrez Gene: MTCP1 mature T-cell proliferation 1".
9. Laine J, Künstle G, Obata T, Noguchi M (February 2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi: 10.1074/jbc.M107069200 . PMID   11707444.
10. Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): 395–407. doi: 10.1016/S1097-2765(00)00039-3 . PMID   10983986.

Further reading

• Kenwrick S, Levinson B, Taylor S, Shapiro A, Gitschier J (1993). "Isolation and sequence of two genes associated with a CpG island 5' of the factor VIII gene". Hum. Mol. Genet. 1 (3): 179–86. doi:10.1093/hmg/1.3.179. PMID   1303175.
• Madani A, Soulier J, Schmid M, Plichtova R, Lermé F, Gateau-Roesch O, Garnier JP, Pla M, Sigaux F, Stern MH (1995). "The 8 kD product of the putative oncogene MTCP-1 is a mitochondrial protein". Oncogene. 10 (11): 2259–62. PMID   7784073.
• Soulier J, Madani A, Cacheux V, Rosenzwajg M, Sigaux F, Stern MH (1994). "The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation". Oncogene. 9 (12): 3565–70. PMID   7970717.
• Thick J, Mak YF, Metcalfe J, Beatty D, Taylor AM (1994). "A gene on chromosome Xq28 associated with T-cell prolymphocytic leukemia in two patients with ataxia telangiectasia". Leukemia. 8 (4): 564–73. PMID   8152252.
• Fisch P, Forster A, Sherrington PD, Dyer MJ, Rabbitts TH (1993). "The chromosomal translocation t(X;14)(q28;q11) in T-cell pro-lymphocytic leukaemia breaks within one gene and activates another". Oncogene. 8 (12): 3271–6. PMID   8247530.
• Gritti C, Choukroun V, Soulier J, Madani A, Dastot H, Leblond V, Radford-Weiss I, Valensi F, Varet B, Sigaux F, Stern MH (1997). "Alternative origin of p13MTCP1-encoding transcripts in mature T-cell proliferations with t(X;14) translocations". Oncogene. 15 (11): 1329–35. doi: 10.1038/sj.onc.1201303 . PMID   9315101.
• Barthe P, Yang YS, Chiche L, Hoh F, Strub MP, Guignard L, Soulier J, Stern MH, van Tilbeurgh H, Lhoste JM, Roumestand C (1998). "Solution structure of human p8MTCP1, a cysteine-rich protein encoded by the MTCP1 oncogene, reveals a new alpha-helical assembly motif" (PDF). J. Mol. Biol. 274 (5): 801–15. doi:10.1006/jmbi.1997.1438. PMID   9405159.
• Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Varnum J, Germann MW, Croce CM (1998). "Purification and characterization of recombinant forms of TCL-1 and MTCP-1 proteins". Protein Expr. Purif. 12 (2): 215–25. doi:10.1006/prep.1997.0822. PMID   9518463.
• Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW (1998). "Crystal structure of MTCP-1: Implications for role of TCL-1 and MTCP-1 in T cell malignancies". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3413–8. Bibcode:1998PNAS...95.3413F. doi: 10.1073/pnas.95.7.3413 . PMC   19850 . PMID   9520380.
• Guignard L, Padilla A, Mispelter J, Yang YS, Stern MH, Lhoste JM, Roumestand C (2000). "Backbone dynamics and solution structure refinement of the 15N-labeled human oncogenic protein p13MTCP1: comparison with X-ray data". J. Biomol. NMR. 17 (3): 215–30. doi:10.1023/A:1008386110930. PMID   10959629. S2CID   46115803.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Laine J, Künstle G, Obata T, Noguchi M (2002). "Differential regulation of Akt kinase isoforms by the members of the TCL1 oncogene family". J. Biol. Chem. 277 (5): 3743–51. doi: 10.1074/jbc.M107069200 . PMID   11707444.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.