MTSS1

MTSS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2D1K
Identifiers
Aliases	MTSS1 , MIM, MIMA, MIMB, metastasis suppressor 1, I-BAR domain containing, MTSS I-BAR domain containing 1
External IDs	OMIM: 608486; MGI: 2384818; HomoloGene: 8841; GeneCards: MTSS1; OMA:MTSS1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q24.13 Start 124,550,784 bp [1] End 124,728,473 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 D1 Start 58,813,083 bp [2] End 58,953,854 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in retinal pigment epithelium glomerulus metanephric glomerulus hair follicle subthalamic nucleus renal medulla skin of hip inferior ganglion of vagus nerve skin of thigh bronchial epithelial cell Top expressed in lobe of cerebellum cerebellar vermis Rostral migratory stream vestibular membrane of cochlear duct stroma of bone marrow zygote habenula secondary oocyte pineal gland iris More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin monomer binding protein binding identical protein binding actin binding signaling receptor binding Cellular component cytoplasm ruffle endocytic vesicle actin cytoskeleton cytoskeleton Biological process renal tubule morphogenesis nephron tubule epithelial cell differentiation transmembrane receptor protein tyrosine kinase signaling pathway cellular response to fluid shear stress cell adhesion epithelial cell proliferation involved in renal tubule morphogenesis microspike assembly negative regulation of epithelial cell proliferation plasma membrane organization actin cytoskeleton organization glomerulus morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9788 211401 Ensembl ENSG00000170873 ENSMUSG00000022353 UniProt O43312 Q8R1S4 RefSeq (mRNA) NM_001282971 NM_001282974 NM_014751 NM_001363294 NM_001363295 NM_001363296 NM_001363297 NM_001363298 NM_001363299 NM_001363300 NM_001363301 NM_001363302 NM_001146180 NM_144800 RefSeq (protein) NP_001269900 NP_001269903 NP_055566 NP_001350223 NP_001350224 NP_001350225 NP_001350226 NP_001350227 NP_001350228 NP_001350229 NP_001350230 NP_001350231 NP_001139652 NP_659049 NP_001390427 NP_001390428 NP_001390429 NP_001390430 NP_001390431 NP_001390432 NP_001390433 NP_001390434 NP_001390435 NP_001390436 Location (UCSC) Chr 8: 124.55 – 124.73 Mb Chr 15: 58.81 – 58.95 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Metastasis suppressor protein 1 is a protein that in humans is encoded by the MTSS1 gene. ^{[5] [6] [7]} True to its name, it codes for a metastasis suppressor.

References

1. GRCh38: Ensembl release 89: ENSG00000170873 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022353 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mattila PK, Salminen M, Yamashiro T, Lappalainen P (Mar 2003). "Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain". J Biol Chem. 278 (10): 8452–9. doi: 10.1074/jbc.M212113200 . PMID   12482861.
6. Lee YG, Macoska JA, Korenchuk S, Pienta KJ (Jun 2002). "MIM, a Potential Metastasis Suppressor Gene in Bladder Cancer". Neoplasia. 4 (4): 291–4. doi:10.1038/sj.neo.7900231. PMC   1531703 . PMID   12082544.
7. "Entrez Gene: MTSS1 metastasis suppressor 1".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307 . PMID   9455477.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Woodings JA, Sharp SJ, Machesky LM (2003). "MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta". Biochem. J. 371 (Pt 2): 463–71. doi:10.1042/BJ20021962. PMC   1223315 . PMID   12570871.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Yamagishi A, Masuda M, Ohki T, et al. (2004). "A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein". J. Biol. Chem. 279 (15): 14929–36. doi: 10.1074/jbc.M309408200 . PMID   14752106.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi: 10.1016/j.molcel.2004.09.016 . PMID   15383276.
• Nixdorf S, Grimm MO, Loberg R, et al. (2004). "Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines". Cancer Lett. 215 (2): 209–20. doi:10.1016/j.canlet.2004.05.002. PMID   15488640.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Callahan CA, Ofstad T, Horng L, et al. (2004). "MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription". Genes Dev. 18 (22): 2724–9. doi:10.1101/gad.1221804. PMC   528890 . PMID   15545630.
• Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE (2005). "Receptor tyrosine phosphatase–dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4". J. Cell Biol. 168 (3): 453–63. doi:10.1083/jcb.200409078. PMC   2171717 . PMID   15684034.
• Bompard G, Sharp SJ, Freiss G, Machesky LM (2006). "Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B". J. Cell Sci. 118 (Pt 22): 5393–403. doi: 10.1242/jcs.02640 . PMID   16280553.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Utikal J, Gratchev A, Muller-Molinet I, et al. (2006). "The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation". Int. J. Cancer. 119 (10): 2287–93. doi: 10.1002/ijc.22106 . PMID   16921485. S2CID   6700103.
• Ma S, Guan XY, Lee TK, Chan KW (2007). "Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma". Hum. Pathol. 38 (8): 1201–6. doi:10.1016/j.humpath.2007.01.004. PMID   17442377.