MTSS1

MTSS1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D1K
Identifiers
Aliases	MTSS1 , MIM, MIMA, MIMB, metastasis suppressor 1, I-BAR domain containing, MTSS I-BAR domain containing 1
External IDs	OMIM: 608486 MGI: 2384818 HomoloGene: 8841 GeneCards: MTSS1
Gene location (Human)
Chr.	Chromosome 8 (human)
End	124,728,473 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	58,953,854 bp
RNA expression pattern
	Top expressed in
	retinal pigment epithelium; ; glomerulus; ; metanephric glomerulus; ; hair follicle; ; subthalamic nucleus; ; renal medulla; ; inferior ganglion of vagus nerve; ; bronchial epithelial cell; ; ventral tegmental area; ; endothelial cell;
	Top expressed in
	cerebellar vermis; ; habenula; ; secondary oocyte; ; pineal gland; ; iris; ; retinal pigment epithelium; ; ciliary body; ; atrioventricular valve; ; barrel cortex; ; left lung lobe;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	actin monomer binding ; protein binding ; identical protein binding ; actin binding ; signaling receptor binding ;
Cellular component	cytoplasm ; ruffle ; endocytic vesicle ; actin cytoskeleton ; cytoskeleton ;
Biological process	renal tubule morphogenesis ; nephron tubule epithelial cell differentiation ; transmembrane receptor protein tyrosine kinase signaling pathway ; cellular response to fluid shear stress ; cell adhesion ; epithelial cell proliferation involved in renal tubule morphogenesis ; microspike assembly ; negative regulation of epithelial cell proliferation ; plasma membrane organization ; actin cytoskeleton organization ; glomerulus morphogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	9788
	211401
	ENSG00000170873
	ENSMUSG00000022353
	O43312
	Q8R1S4
NM_001282971 ; NM_001282974 ; NM_014751 ; NM_001363294 ; NM_001363295 ;
	NM_001363296 ; NM_001363297 ; NM_001363298 ; NM_001363299 ; NM_001363300 ; NM_001363301 ; NM_001363302
	NM_001146180 ; NM_144800
NP_001269900 ; NP_001269903 ; NP_055566 ; NP_001350223 ; NP_001350224 ;
	NP_001350225 ; NP_001350226 ; NP_001350227 ; NP_001350228 ; NP_001350229 ; NP_001350230 ; NP_001350231
NP_001139652 ; NP_659049 ; NP_001390427 ; NP_001390428 ; NP_001390429 ;
	NP_001390430 ; NP_001390431 ; NP_001390432 ; NP_001390433 ; NP_001390434 ; NP_001390435 ; NP_001390436
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Metastasis suppressor protein 1 is a protein that in humans is encoded by the MTSS1 gene.^[5]^[6]^[7] True to its name, it codes for a metastasis suppressor.

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In molecular biology, the IMD domain is a BAR-like domain of approximately 250 amino acids found at the N-terminus in the insulin receptor tyrosine kinase substrate p53 (IRSp53/BAIAP2) and in the evolutionarily related IRSp53/MIM (MTSS1) family. In IRSp53, a ubiquitous regulator of the actin cytoskeleton, the IMD domain acts as conserved F-actin bundling domain involved in filopodium formation. Filopodium-inducing IMD activity is regulated by Cdc42 and Rac1 and is SH3-independent. The IRSp53/MIM family is a novel F-actin bundling protein family that includes invertebrate relatives:

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170873 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022353 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Mattila PK, Salminen M, Yamashiro T, Lappalainen P (Mar 2003). "Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain". J Biol Chem. 278 (10): 8452–9. doi: 10.1074/jbc.M212113200 . PMID 12482861.
↑ Lee YG, Macoska JA, Korenchuk S, Pienta KJ (Jun 2002). "MIM, a Potential Metastasis Suppressor Gene in Bladder Cancer". Neoplasia. 4 (4): 291–4. doi:10.1038/sj.neo.7900231. PMC 1531703 . PMID 12082544.
↑ "Entrez Gene: MTSS1 metastasis suppressor 1".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Ishikawa K, Nagase T, Nakajima D, et al. (1998). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 4 (5): 307–13. doi: 10.1093/dnares/4.5.307 . PMID 9455477.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Woodings JA, Sharp SJ, Machesky LM (2003). "MIM-B, a putative metastasis suppressor protein, binds to actin and to protein tyrosine phosphatase delta". Biochem. J. 371 (Pt 2): 463–71. doi:10.1042/BJ20021962. PMC 1223315 . PMID 12570871.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Yamagishi A, Masuda M, Ohki T, et al. (2004). "A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein". J. Biol. Chem. 279 (15): 14929–36. doi: 10.1074/jbc.M309408200 . PMID 14752106.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi: 10.1016/j.molcel.2004.09.016 . PMID 15383276.
Nixdorf S, Grimm MO, Loberg R, et al. (2004). "Expression and regulation of MIM (Missing In Metastasis), a novel putative metastasis suppressor gene, and MIM-B, in bladder cancer cell lines". Cancer Lett. 215 (2): 209–20. doi:10.1016/j.canlet.2004.05.002. PMID 15488640.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Callahan CA, Ofstad T, Horng L, et al. (2004). "MIM/BEG4, a Sonic hedgehog-responsive gene that potentiates Gli-dependent transcription". Genes Dev. 18 (22): 2724–9. doi:10.1101/gad.1221804. PMC 528890 . PMID 15545630.
Gonzalez-Quevedo R, Shoffer M, Horng L, Oro AE (2005). "Receptor tyrosine phosphatase–dependent cytoskeletal remodeling by the hedgehog-responsive gene MIM/BEG4". J. Cell Biol. 168 (3): 453–63. doi:10.1083/jcb.200409078. PMC 2171717 . PMID 15684034.
Bompard G, Sharp SJ, Freiss G, Machesky LM (2006). "Involvement of Rac in actin cytoskeleton rearrangements induced by MIM-B". J. Cell Sci. 118 (Pt 22): 5393–403. doi: 10.1242/jcs.02640 . PMID 16280553.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Utikal J, Gratchev A, Muller-Molinet I, et al. (2006). "The expression of metastasis suppressor MIM/MTSS1 is regulated by DNA methylation". Int. J. Cancer. 119 (10): 2287–93. doi: 10.1002/ijc.22106 . PMID 16921485. S2CID 6700103.
Ma S, Guan XY, Lee TK, Chan KW (2007). "Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma". Hum. Pathol. 38 (8): 1201–6. doi:10.1016/j.humpath.2007.01.004. PMID 17442377.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170873 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022353 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12482861-5] Mattila PK, Salminen M, Yamashiro T, Lappalainen P (Mar 2003). "Mouse MIM, a tissue-specific regulator of cytoskeletal dynamics, interacts with ATP-actin monomers through its C-terminal WH2 domain". J Biol Chem. 278 (10): 8452–9. doi: 10.1074/jbc.M212113200 . PMID 12482861.

[pmid12082544-6] Lee YG, Macoska JA, Korenchuk S, Pienta KJ (Jun 2002). "MIM, a Potential Metastasis Suppressor Gene in Bladder Cancer". Neoplasia. 4 (4): 291–4. doi:10.1038/sj.neo.7900231. PMC 1531703 . PMID 12082544.

[entrez-7] "Entrez Gene: MTSS1 metastasis suppressor 1".

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MTSS1

Related Research Articles

References

Further reading