MTUS1

MTUS1
Identifiers
Aliases	MTUS1 , ATBP, ATIP, ICIS, MP44, MTSG1, microtubule associated tumor suppressor 1, microtubule associated scaffold protein 1, ATIP3
External IDs	OMIM: 609589; MGI: 2142572; HomoloGene: 100292; GeneCards: MTUS1; OMA:MTUS1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8p22 Start 17,643,795 bp [1] End 17,801,094 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 A4 Start 41,443,951 bp [2] End 41,586,763 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum inferior ganglion of vagus nerve inferior olivary nucleus body of pancreas thoracic diaphragm right ventricle subthalamic nucleus biceps brachii C1 segment Skeletal muscle tissue of biceps brachii Top expressed in zygote secondary oocyte primary oocyte granulocyte interventricular septum lobe of cerebellum cerebellar vermis myocardium of ventricle aortic valve knee joint More reference expression data BioGPS More reference expression data
Gene ontology Molecular function microtubule binding Cellular component cytoplasm plasma membrane Golgi apparatus spindle microtubule cytoskeleton membrane mitochondrion nucleus microtubule organizing center extracellular space nucleolus microtubule cytoskeleton Biological process regulation of macrophage chemotaxis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57509 102103 Ensembl ENSG00000129422 ENSMUSG00000045636 UniProt Q9ULD2 Q5HZI1 RefSeq (mRNA) NM_001001924 NM_001001925 NM_001001927 NM_001001931 NM_001166393 NM_020749 NM_001330470 NM_001363057 NM_001363058 NM_001363059 NM_001363060 NM_001363061 NM_001363062 NM_001005863 NM_001005864 NM_001005865 NM_001286413 RefSeq (protein) NP_001001924 NP_001001925 NP_001001931 NP_001159865 NP_001317399 NP_065800 NP_001349986 NP_001349987 NP_001349988 NP_001349989 NP_001349990 NP_001349991 NP_001005863 NP_001005864 NP_001005865 NP_001273342 NP_001390875 NP_001390876 NP_001390879 NP_001390881 NP_001390883 NP_001390884 NP_001390885 Location (UCSC) Chr 8: 17.64 – 17.8 Mb Chr 8: 41.44 – 41.59 Mb PubMed search [3] [4]
Wikidata
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Mitochondrial tumor suppressor 1 (MTSG1) or Microtubule-Associated Scaffold Protein 1 (MTUS1) is a candidate tumor suppressor protein encoded by the MTUS1 gene in humans. ^{[5] [6]} Expression levels of MTUS1 was reported to be lost in various types of human malignancies such as colon, ovarian, head-and-neck, pancreas, breast cancers, bladder, gastric, and lung cancers. ^{[7] [8]}

Proteins encoded by MTUS1

As a result of alternative splicing MTUS1 was shown to encode 5 different protein isoforms as listed as ATIP1, ATIP2, ATIP3a, ATIP3b and ATIP4. ATIP3a and ATIP3b was generally considered as ATIP3 and ATIP1 and ATIP3 is the major splice variants encoded by MTUS1 gene. ^[9]

Function

This gene encodes a protein which contains a C-terminal domain able to interact with the angiotensin II receptor type 2 (AT2) and a large coiled-coil region allowing dimerization. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the transcript variants has been shown to encode a mitochondrial protein that acts as a tumor suppressor and participates in AT2 signaling pathways. Other variants may encode nuclear or transmembrane proteins but it has not been determined whether they also participate in AT2 signaling pathways. ^[10]

Interactions

MTUS1 has been shown to interact with Angiotensin II receptor type 2. ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000129422 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000045636 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kara M, Kaplan M, Bozgeyik I, Ozcan O, Celik OI, Bozgeyik E, Yumrutas O (August 2016). "MTUS1 tumor suppressor and its miRNA regulators in fibroadenoma and breast cancer". Gene. 587 (2): 173–7. doi:10.1016/j.gene.2016.05.006. PMID   27155522.
6. Bozgeyik I, Yumrutas O, Bozgeyik E (August 2017). "MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis". Gene. 626: 54–63. doi:10.1016/j.gene.2017.05.019. PMID   28499941.
7. Bozgeyik I, Yumrutas O, Bozgeyik E (August 2017). "MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis". Gene. 626: 54–63. doi:10.1016/j.gene.2017.05.019. PMID   28499941.
8. Ozcan O, Kara M, Yumrutas O, Bozgeyik E, Bozgeyik I, Celik OI (May 2016). "MTUS1 and its targeting miRNAs in colorectal carcinoma: significant associations". Tumour Biology. 37 (5): 6637–45. doi:10.1007/s13277-015-4550-4. PMID   26643896. S2CID   25574850.
9. Bozgeyik I, Yumrutas O, Bozgeyik E (August 2017). "MTUS1, a gene encoding angiotensin-II type 2 (AT2) receptor-interacting proteins, in health and disease, with special emphasis on its role in carcinogenesis". Gene. 626: 54–63. doi:10.1016/j.gene.2017.05.019. PMID   28499941.
10. "Entrez Gene: MTUS1 mitochondrial tumor suppressor 1".
11. Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (July 2004). "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP". The Journal of Biological Chemistry. 279 (28): 28989–97. doi: 10.1074/jbc.M403880200 . PMID   15123706.

Further reading

• Di Benedetto M, Pineau P, Nouet S, Berhouet S, Seitz I, Louis S, Dejean A, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Nahmias C (June 2006). "Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP/MTUS1 in hepatocellular carcinoma". Molecular and Cellular Endocrinology. 252 (1–2): 207–15. doi:10.1016/j.mce.2006.03.014. PMID   16650523. S2CID   19420252.
• Frank B, Bermejo JL, Hemminki K, Sutter C, Wappenschmidt B, Meindl A, Kiechle-Bahat M, Bugert P, Schmutzler RK, Bartram CR, Burwinkel B (July 2007). "Copy number variant in the candidate tumor suppressor gene MTUS1 and familial breast cancer risk". Carcinogenesis. 28 (7): 1442–5. doi: 10.1093/carcin/bgm033 . PMID   17301065.
• Di Benedetto M, Bièche I, Deshayes F, Vacher S, Nouet S, Collura V, Seitz I, Louis S, Pineau P, Amsellem-Ouazana D, Couraud PO, Strosberg AD, Stoppa-Lyonnet D, Lidereau R, Nahmias C (October 2006). "Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP". Gene. 380 (2): 127–36. doi:10.1016/j.gene.2006.05.021. PMID   16887298.
• Nouet S, Amzallag N, Li JM, Louis S, Seitz I, Cui TX, Alleaume AM, Di Benedetto M, Boden C, Masson M, Strosberg AD, Horiuchi M, Couraud PO, Nahmias C (July 2004). "Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP". The Journal of Biological Chemistry. 279 (28): 28989–97. doi: 10.1074/jbc.M403880200 . PMID   15123706.