MUPCDH

CDHR5
Identifiers
Aliases	CDHR5 , MU-PCDH, MUCDHL, MUPCDH, MLPCDH, cadherin related family member 5
External IDs	OMIM: 606839 MGI: 1919290 HomoloGene: 69345 GeneCards: CDHR5
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.5 Start 616,577 bp [1] End 626,078 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 F5 Start 140,848,996 bp [2] End 140,856,699 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum rectum right lobe of liver kidney gallbladder sural nerve appendix renal cortex islet of Langerhans stomach Top expressed in duodenum large intestine colon jejunum crypt of lieberkuhn of small intestine ileum left colon kidney proximal tubule yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding beta-catenin binding protein binding cell adhesion molecule binding Cellular component integral component of membrane spanning component of plasma membrane brush border membrane clathrin-coated pit plasma membrane extracellular exosome membrane cell projection microvillus membrane apical plasma membrane Biological process cell adhesion regulation of microvillus length homophilic cell adhesion via plasma membrane adhesion molecules intermicrovillar adhesion cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 53841 72040 Ensembl ENSG00000099834 ENSG00000273572 ENSMUSG00000025497 UniProt Q9HBB8 Q8VHF2 RefSeq (mRNA) NM_001171968 NM_017717 NM_021924 NM_031264 NM_031265 NM_001114322 NM_028069 RefSeq (protein) NP_001165439 NP_068743 NP_112554 NP_001107794 NP_082345 Location (UCSC) Chr 11: 0.62 – 0.63 Mb Chr 7: 140.85 – 140.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Mucin and cadherin-like protein is a protein that in humans is encoded by the MUPCDH gene. ^{[5] [6] [7]}

This gene is a novel mucin-like gene that is a member of the cadherin superfamily. While encoding nonpolymorphic tandem repeats rich in proline, serine and threonine similar to mucin proteins, the gene also contains sequence encoding calcium-binding motifs found in all cadherins. The role of the hybrid extracellular region and the specific function of this protein have not yet been determined. Alternative splicing has been identified, with observed variation resulting in the presence or absence of domains. In addition, splicing occurs in the 5' UTR but transcripts including these variations have not been described completely. ^[7]

References

1. ENSG00000273572 GRCh38: Ensembl release 89: ENSG00000099834, ENSG00000273572 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025497 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Paris MJ, Williams BR (Jan 2001). "Characterization of a 500-kb contig spanning the region between c-Ha-Ras and MUC2 on chromosome 11p15.5". Genomics. 69 (2): 196–202. doi:10.1006/geno.2000.6339. PMID   11031102.
6. Goldberg M, Peshkovsky C, Shifteh A, Al-Awqati Q (Sep 2000). "mu-Protocadherin, a novel developmentally regulated protocadherin with mucin-like domains". J Biol Chem. 275 (32): 24622–9. doi: 10.1074/jbc.M000234200 . PMID   10801787. S2CID   42493271.
7. "Entrez Gene: MUCDHL mucin and cadherin-like".

Further reading

• Yagi T, Takeichi M (2000). "Cadherin superfamily genes: functions, genomic organization, and neurologic diversity". Genes Dev. 14 (10): 1169–80. doi: 10.1101/gad.14.10.1169 . PMID   10817752. S2CID   44844497.
• Goldberg M, Wei M, Tycko B, et al. (2002). "Identification and expression analysis of the human mu-protocadherin gene in fetal and adult kidneys". Am. J. Physiol. Renal Physiol. 283 (3): F454–63. doi:10.1152/ajprenal.00012.2002. PMID   12167596. S2CID   615952.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Goldberg M, Wei M, Yuan L, et al. (2003). "Biallelic expression of HRAS and MUCDHL in human and mouse". Hum. Genet. 112 (4): 334–42. doi:10.1007/s00439-003-0907-7. PMID   12589428. S2CID   1143721.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039. S2CID   21903526.
• Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.