MXRA5

MXRA5
Identifiers
Aliases	MXRA5 , matrix remodeling associated 5
External IDs	OMIM: 300938 HomoloGene: 56704 GeneCards: MXRA5
Gene location (Human)
Chr.	X chromosome (human)
End	3,346,652 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; urethra; ; vulva; ; pylorus; ; cardia; ; parietal pleura; ; nipple; ; human penis; ; synovial joint; ; tibia;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function ; extracellular matrix structural constituent ;
Cellular component	extracellular exosome ; extracellular region ; collagen-containing extracellular matrix ;
Biological process	response to transforming growth factor beta ;
	Sources:Amigo / QuickGO
Orthologs
	25878
	n/a
	ENSG00000101825
	n/a
	Q9NR99
	n/a
	NM_015419
	n/a
	NP_056234
	n/a
	Wikidata
View/Edit Human

Last updated January 22, 2024

Matrix-remodelling associated 5 is a protein in humans that is encoded by the MXRA5 gene.^[3]

Function

This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y.^[3]

Clinical relevance

Mutations in this gene have been seen frequently mutated in cases of non-small cell lung carcinoma.^[4]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101825 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Matrix-remodelling associated 5" . Retrieved 2012-07-24.
↑ Xiong D, Li G, Li K, Xu Q, Pan Z, Ding F, Vedell P, Liu P, Cui P, Hua X, Jiang H, Yin Y, Zhu Z, Li X, Zhang B, Ma D, Wang Y, You M (Sep 2012). "Exome sequencing identifies MXRA5 as a novel cancer gene frequently mutated in non-small cell lung carcinoma from Chinese patients". Carcinogenesis. 33 (9): 1797–805. doi:10.1093/carcin/bgs210. PMC 3514907 . PMID 22696596.

MXRA5

Contents

Function

Clinical relevance

Related Research Articles

References

Further reading