MYBPC1

MYBPC1
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1X44, 2DAV, 2YUV, 2YUW, 2YUX, 2YUZ, 2YXM
Identifiers
Aliases	MYBPC1 , LCCS4, MYBPCC, MYBPCS, myosin binding protein C, slow type, ssMyBP-C, MYOTREM, myosin binding protein C1
External IDs	OMIM: 160794 MGI: 1336213 HomoloGene: 1846 GeneCards: MYBPC1
Gene location (Human)
Chr.	Chromosome 12 (human)
End	101,686,028 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	88,441,014 bp
RNA expression pattern
	Top expressed in
	biceps brachii; ; deltoid muscle; ; gastrocnemius muscle; ; vastus lateralis muscle; ; triceps brachii muscle; ; thoracic diaphragm; ; tibialis anterior muscle; ; body of tongue; ; optic nerve; ; internal globus pallidus;
	Top expressed in
	temporal muscle; ; ankle; ; soleus muscle; ; sternocleidomastoid muscle; ; digastric muscle; ; tibialis anterior muscle; ; extraocular muscle; ; thoracic diaphragm; ; vastus lateralis muscle; ; gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding ; structural constituent of muscle ; protein binding ; titin binding ; actin filament binding ; muscle alpha-actinin binding ; structural molecule activity conferring elasticity ;
Cellular component	myosin filament ; cytosol ; myofibril ; muscle myosin complex ; Z disc ; M band ; striated muscle thin filament ; sarcomere ;
Biological process	cell adhesion ; muscle contraction ; muscle filament sliding ; striated muscle contraction ; actin filament organization ; sarcomere organization ; striated muscle myosin thick filament assembly ; skeletal muscle thin filament assembly ; skeletal muscle myosin thick filament assembly ; cardiac myofibril assembly ; cardiac muscle tissue morphogenesis ;
	Sources:Amigo / QuickGO
Orthologs
	4604
	109272
	ENSG00000196091
	ENSMUSG00000020061
	Q00872
	n/a
NM_001254718 ; NM_001254719 ; NM_001254720 ; NM_001254721 ; NM_001254722 ;
	NM_001254723 ; NM_002465 ; NM_206819 ; NM_206820 ; NM_206821 ; NM_001404675 ; NM_001404676 ; NM_001404677 ; NM_001404678 ; NM_001404679 ; NM_001404680 ; NM_001404681
	NM_001252372 ; NM_175418
NP_001241647 ; NP_001241648 ; NP_001241649 ; NP_001241650 ; NP_001241651 ;
	NP_001241652 ; NP_002456 ; NP_996555 ; NP_996556 ; NP_996557
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 06, 2023

Myosin-binding protein C, slow-type is a protein that in humans is encoded by the MYBPC1 gene.^[5]^[6]^[7]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196091 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020061 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Weber FE, Vaughan KT, Reinach FC, Fischman DA (Oct 1993). "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment". Eur J Biochem. 216 (2): 661–9. doi:10.1111/j.1432-1033.1993.tb18186.x. PMID 8375400.
↑ Flashman E, Watkins H, Redwood C (Dec 2006). "Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod". Biochem J. 401 (1): 97–102. doi:10.1042/BJ20060500. PMC 1698665 . PMID 16918501.
↑ "Entrez Gene: MYBPC1 myosin binding protein C, slow type".

Fürst DO, Vinkemeier U, Weber K (1992). "Mammalian skeletal muscle C-protein: purification from bovine muscle, binding to titin and the characterization of a full-length human cDNA". J. Cell Sci. 102 (4): 769–78. doi:10.1242/jcs.102.4.769. PMID 1429890.
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Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags". Genome Res. 6 (9): 807–28. doi: 10.1101/gr.6.9.807 . PMID 8889549.
Alyonycheva TN, Mikawa T, Reinach FC, Fischman DA (1997). "Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain". J. Biol. Chem. 272 (33): 20866–72. doi: 10.1074/jbc.272.33.20866 . PMID 9252413.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072 . PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Welikson RE, Fischman DA (2003). "The C-terminal IgI domains of myosin-binding proteins C and H (MyBP-C and MyBP-H) are both necessary and sufficient for the intracellular crosslinking of sarcomeric myosin in transfected non-muscle cells". J. Cell Sci. 115 (Pt 17): 3517–26. doi: 10.1242/jcs.115.17.3517 . PMID 12154082.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Konno T, Shimizu M, Ino H, et al. (2003). "A novel missense mutation in the myosin binding protein-C gene is responsible for hypertrophic cardiomyopathy with left ventricular dysfunction and dilation in elderly patients". J. Am. Coll. Cardiol. 41 (5): 781–6. doi:10.1016/S0735-1097(02)02957-1. hdl: 2297/15819 . PMID 12628722.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Beatham J, Romero R, Townsend SK, et al. (2006). "Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres". Hum. Mol. Genet. 13 (22): 2863–74. doi: 10.1093/hmg/ddh308 . PMID 15385448.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Dhoot GK, Perry SV (2006). "Expression of slow skeletal myosin binding C-protein in normal adult mammalian heart". J. Muscle Res. Cell. Motil. 26 (2–3): 143–8. doi:10.1007/s10974-005-3089-1. PMID 16003462. S2CID 12278011.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.
McGrath MJ, Cottle DL, Nguyen MA, et al. (2006). "Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly". J. Biol. Chem. 281 (11): 7666–83. doi: 10.1074/jbc.M512552200 . PMID 16407297.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196091 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020061 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8375400-5] Weber FE, Vaughan KT, Reinach FC, Fischman DA (Oct 1993). "Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment". Eur J Biochem. 216 (2): 661–9. doi:10.1111/j.1432-1033.1993.tb18186.x. PMID 8375400.

[pmid16918501-6] Flashman E, Watkins H, Redwood C (Dec 2006). "Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod". Biochem J. 401 (1): 97–102. doi:10.1042/BJ20060500. PMC 1698665 . PMID 16918501.

[entrez-7] "Entrez Gene: MYBPC1 myosin binding protein C, slow type".

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MYBPC1

Related Research Articles

References

Further reading