MYOZ1

MYOZ1
Identifiers
Aliases	MYOZ1 , CS-2, FATZ, MYOZ, myozenin 1
External IDs	OMIM: 605603; MGI: 1929471; HomoloGene: 23311; GeneCards: MYOZ1; OMA:MYOZ1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q22.2 Start 73,631,612 bp [1] End 73,641,474 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 A3 Start 20,699,175 bp [2] End 20,706,608 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh Skeletal muscle tissue of rectus abdominis gastrocnemius muscle biceps brachii vastus lateralis muscle Skeletal muscle tissue of biceps brachii triceps brachii muscle glutes thoracic diaphragm deltoid muscle Top expressed in temporal muscle triceps brachii muscle muscle of thigh sternocleidomastoid muscle medial head of gastrocnemius muscle digastric muscle ankle quadriceps femoris muscle tibialis anterior muscle extensor digitorum longus muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function FATZ binding protein binding actin binding telethonin binding protein serine/threonine phosphatase inhibitor activity Cellular component cell projection nucleus pseudopodium actin cytoskeleton Z discdkac Biological process myofibril assembly negative regulation of transcription by RNA polymerase II skeletal muscle tissue development negative regulation of phosphoprotein phosphatase activity negative regulation of skeletal muscle tissue regeneration skeletal muscle fiber adaptation sarcomere organization negative regulation of calcineurin-NFAT signaling cascade Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58529 59011 Ensembl ENSG00000177791 ENSMUSG00000068697 UniProt Q9NP98 Q9JK37 RefSeq (mRNA) NM_021245 NM_021508 RefSeq (protein) NP_067068 NP_067483 Location (UCSC) Chr 10: 73.63 – 73.64 Mb Chr 14: 20.7 – 20.71 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Myozenin-1 is a protein that in humans is encoded by the MYOZ1 gene. ^{[5] [6] [7]}

Interactions

MYOZ1 has been shown to interact with Telethonin, ^{[6] [8]} FLNC ^{[5] [6] [8]} and Actinin, alpha 2. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000177791 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000068697 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Takada F, Vander Woude DL, Tong HQ, Thompson TG, Watkins SC, Kunkel LM, Beggs AH (Feb 2001). "Myozenin: an alpha-actinin- and gamma-filamin-binding protein of skeletal muscle Z lines". Proc Natl Acad Sci USA. 98 (4): 1595–600. doi: 10.1073/pnas.041609698 . PMC   29302 . PMID   11171996.
6. Faulkner G, Pallavicini A, Comelli A, Salamon M, Bortoletto G, Ievolella C, Trevisan S, Kojic' S, Dalla Vecchia F, Laveder P, Valle G, Lanfranchi G (Jan 2001). "FATZ, a filamin-, actinin-, and telethonin-binding protein of the Z-disc of skeletal muscle". J Biol Chem. 275 (52): 41234–42. doi: 10.1074/jbc.M007493200 . PMID   10984498.
7. "Entrez Gene: MYOZ1 myozenin 1".
8. Frey, Norbert; Olson Eric N (Apr 2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. 277 (16): 13998–4004. doi: 10.1074/jbc.M200712200 . ISSN   0021-9258. PMID   11842093.

Further reading

• Faulkner G, Pallavicini A, Formentin E, et al. (1999). "ZASP: a new Z-band alternatively spliced PDZ-motif protein". J. Cell Biol. 146 (2): 465–75. doi:10.1083/jcb.146.2.465. PMC   3206570 . PMID   10427098.
• Frey N, Richardson JA, Olson EN (2001). "Calsarcins, a novel family of sarcomeric calcineurin-binding proteins". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14632–7. Bibcode:2000PNAS...9714632F. doi: 10.1073/pnas.260501097 . PMC   18970 . PMID   11114196.
• Frey N, Olson EN (2002). "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin family, interacts with multiple Z-disc proteins". J. Biol. Chem. 277 (16): 13998–4004. doi: 10.1074/jbc.M200712200 . PMID   11842093.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gontier Y, Taivainen A, Fontao L, et al. (2006). "The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins". J. Cell Sci. 118 (Pt 16): 3739–49. doi: 10.1242/jcs.02484 . PMID   16076904.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Arola AM, Sanchez X, Murphy RT, et al. (2007). "Mutations in PDLIM3 and MYOZ1 encoding myocyte Z line proteins are infrequently found in idiopathic dilated cardiomyopathy". Mol. Genet. Metab. 90 (4): 435–40. doi:10.1016/j.ymgme.2006.12.008. PMID   17254821.
• Posch MG, Perrot A, Dietz R, et al. (2007). "Mutations in MYOZ1 as well as MYOZ2 encoding the calsarcins are not associated with idiopathic and familial dilated cardiomyopathy" (PDF). Mol. Genet. Metab. 91 (2): 207–8. doi:10.1016/j.ymgme.2007.02.014. PMID   17434779.