Macrophage-capping protein

CAPG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1J72, 1JHW
Identifiers
Aliases	CAPG , AFCP, HEL-S-66, MCP, capping actin protein, gelsolin like
External IDs	OMIM: 153615 MGI: 1098259 HomoloGene: 37523 GeneCards: CAPG
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,418,432 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,539,966 bp
RNA expression pattern
	Top expressed in
	monocyte; ; skin of abdomen; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; upper lobe of left lung; ; right lung; ; gums; ; bone marrow; ; canal of the cervix; ; minor salivary gland;
	Top expressed in
	corneal stroma; ; lip; ; ankle joint; ; conjunctival fornix; ; esophagus; ; ankle; ; calvaria; ; pyloric antrum; ; spleen; ; sciatic nerve;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding ; actin binding ; protein binding ; protein domain specific binding ; cadherin binding ; actin filament binding ;
Cellular component	cytoplasm ; F-actin capping protein complex ; melanosome ; centriole ; mitotic spindle ; nucleolus ; extracellular exosome ; nucleus ; Flemming body ; nucleoplasm ; extracellular region ; ruffle ; lamellipodium ; cell projection ;
Biological process	barbed-end actin filament capping ; extracellular matrix disassembly ; positive regulation of podosome assembly ; actin filament capping ; protein-containing complex assembly ;
	Sources:Amigo / QuickGO
Orthologs
	822
	12332
	ENSG00000042493
	ENSMUSG00000056737
	P40121
	P24452
NM_001256139 ; NM_001256140 ; NM_001747 ; NM_001320732 ; NM_001320733 ;
	NM_001320734
	NM_001042534 ; NM_001271395 ; NM_001271415 ; NM_007599
NP_001243068 ; NP_001243069 ; NP_001307661 ; NP_001307662 ; NP_001307663 ;
	NP_001738
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 25, 2023

Macrophage-capping protein (CAPG) also known as actin regulatory protein CAP-G is a protein that in humans is encoded by the CAPG gene.^[5]^[6]^[7]

Function

This gene encodes a member of the gelsolin/villin family of actin-regulatory proteins.^[8] The encoded protein reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, the encoded protein contributes to the control of actin-based motility in non-muscle cells. Alternatively, spliced transcript variants have been observed, but have not been fully described.^[7]

Related Research Articles

Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency.

Cortactin is a monomeric protein located in the cytoplasm of cells that can be activated by external stimuli to promote polymerization and rearrangement of the actin cytoskeleton, especially the actin cortex around the cellular periphery. It is present in all cell types. When activated, it will recruit Arp2/3 complex proteins to existing actin microfilaments, facilitating and stabilizing nucleation sites for actin branching. Cortactin is important in promoting lamellipodia formation, invadopodia formation, cell migration, and endocytosis.

Keratin, type II cytoskeletal 8 also known as cytokeratin-8 (CK-8) or keratin-8 (K8) is a keratin protein that is encoded in humans by the KRT8 gene. It is often paired with keratin 18.

Ezrin also known as cytovillin or villin-2 is a protein that in humans is encoded by the EZR gene.

Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.

Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.

Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.

Vasodilator-stimulated phosphoprotein is a protein that in humans is encoded by the VASP gene.

Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.

Zyxin is a protein that in humans is encoded by the ZYX gene.

Macrophage-stimulating protein (MSP), also known as hepatocyte growth factor-like protein, is a protein that in humans is encoded by the MST1 gene.

F-actin-capping protein subunit alpha-1 is a protein that in humans is encoded by the CAPZA1 gene.

Protein flightless-1 homolog is a protein that in humans is encoded by the FLII gene.

Neurabin-2 is a protein that in humans is encoded by the PPP1R9B gene.

Cdc42 effector protein 1 is a protein that in humans is encoded by the CDC42EP1 gene.

Supervillin is a protein that in humans is encoded by the SVIL gene.

Tensin-1 is a protein that in humans is encoded by the TNS1 gene.

Tropomodulin 4 (muscle) also known as TMOD4 is a protein which in humans is encoded by the TMOD4 gene.

<span class="mw-page-title-main">Thomas P. Stossel</span> American physician-researcher (1941–2019)

Thomas P. Stossel was an American hematologist, inventor, medical researcher, and writer that discovered gelsolin, and invented the BioAegis technology estate. He was also a professor emeritus of medicine at Harvard Medical School and professor emeritus of clinical research at the American Cancer Society. He was Chief Scientific Advisor to BioAegis Therapeutics Inc., a clinical stage biotech company developing a non-immunosuppressive, anti-inflammatory with potential to address a wide range of infectious, inflammatory and degenerative diseases. He is the holder of more than 50 patents and had authored more than 300 papers, studies, and reviews. He was also a member of the National Academy of Sciences, the American Academy of Arts and Sciences, and the National Academy of Medicine, past editor-in-chief of Current Opinion in Hematology and past editor of the Journal of Clinical Investigation, past president of the American Society of Hematology and the American Society for Clinical Investigation.

Villin 1 is a protein that in humans is encoded by the VIL1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000042493 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056737 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Dabiri GA, Young CL, Rosenbloom J, Southwick FS (Sep 1992). "Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages". J Biol Chem. 267 (23): 16545–52. doi: 10.1016/S0021-9258(18)42037-6 . PMID 1322908.
↑ Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, Silacci P (Jul 2003). "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress". J Biol Chem. 278 (31): 29136–44. doi: 10.1074/jbc.M300598200 . PMID 12754261.
1 2 "Entrez Gene: CAPG capping protein (actin filament), gelsolin-like".
↑ Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

Southwick FS (1995). "Gain-of-function mutations conferring actin-severing activity to human macrophage cap G". J. Biol. Chem. 270 (1): 45–8. doi: 10.1074/jbc.270.1.45 . PMID 7814409.
Mishra VS, Henske EP, Kwiatkowski DJ, Southwick FS (1995). "The human actin-regulatory protein cap G: gene structure and chromosome location". Genomics. 23 (3): 560–5. doi:10.1006/geno.1994.1543. PMID 7851883.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Hirano T, Kobayashi R, Hirano M (1997). "Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein". Cell. 89 (4): 511–21. doi: 10.1016/S0092-8674(00)80233-0 . PMID 9160743. S2CID 15061740.
Cabello OA, Eliseeva E, He WG, et al. (2002). "Cell cycle-dependent expression and nucleolar localization of hCAP-H". Mol. Biol. Cell. 12 (11): 3527–37. doi:10.1091/mbc.12.11.3527. PMC 60273 . PMID 11694586.
Van Impe K, De Corte V, Eichinger L, et al. (2003). "The Nucleo-cytoplasmic actin-binding protein CapG lacks a nuclear export sequence present in structurally related proteins". J. Biol. Chem. 278 (20): 17945–52. doi: 10.1074/jbc.M209946200 . PMID 12637565.
De Corte V, Van Impe K, Bruyneel E, et al. (2005). "Increased importin-beta-dependent nuclear import of the actin modulating protein CapG promotes cell invasion". J. Cell Sci. 117 (Pt 22): 5283–92. doi: 10.1242/jcs.01410 . PMID 15454578.
Watari A, Takaki K, Higashiyama S, et al. (2007). "Suppression of tumorigenicity, but not anchorage independence, of human cancer cells by new candidate tumor suppressor gene CapG". Oncogene. 25 (56): 7373–80. doi: 10.1038/sj.onc.1209732 . PMID 16767159.
Chi A, Valencia JC, Hu ZZ, et al. (2007). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". J. Proteome Res. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000042493 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000056737 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1322908-5] Dabiri GA, Young CL, Rosenbloom J, Southwick FS (Sep 1992). "Molecular cloning of human macrophage capping protein cDNA. A unique member of the gelsolin/villin family expressed primarily in macrophages". J Biol Chem. 267 (23): 16545–52. doi: 10.1016/S0021-9258(18)42037-6 . PMID 1322908.

[pmid12754261-6] Pellieux C, Desgeorges A, Pigeon CH, Chambaz C, Yin H, Hayoz D, Silacci P (Jul 2003). "Cap G, a gelsolin family protein modulating protective effects of unidirectional shear stress". J Biol Chem. 278 (31): 29136–44. doi: 10.1074/jbc.M300598200 . PMID 12754261.

[entrez-7] 1 2 "Entrez Gene: CAPG capping protein (actin filament), gelsolin-like".

[8] Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256. S2CID 205643538.

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Macrophage-capping protein

Contents

Function

Related Research Articles

References

Further reading