Magnesium L-threonate

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Magnesium L-threonate
Magnesium threonate.png
Names
IUPAC name
Magnesium bis[(2R,3S)-2,3,4-trihydroxybutanoate]
Other names
MgT
Identifiers
3D model (JSmol)
ChemSpider
PubChem CID
  • InChI=1S/2C4H8O5.Mg/c2*5-1-2(6)3(7)4(8)9;/h2*2-3,5-7H,1H2,(H,8,9);/q;;+2/p-2/t2*2-,3+;/m00./s1 X mark.svgN
    Key: YVJOHOWNFPQSPP-BALCVSAKSA-L X mark.svgN
  • InChI=1/2C4H8O5.Mg/c2*5-1-2(6)3(7)4(8)9;/h2*2-3,5-7H,1H2,(H,8,9);/q;;+2/p-2/t2*2-,3+;/m00./s1
    Key: YVJOHOWNFPQSPP-HSLCKNDHBH
  • [O-]C([C@H](O)[C@@H](O)CO)=O.[O-]C([C@H](O)[C@@H](O)CO)=O.[Mg+2]
Properties
C8H14MgO10
Molar mass 294.495 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Magnesium L-threonate is a magnesium salt of L-threonic acid having the formula Mg(C4H7O5)2. [1]

Magnesium L-threonate is purported to cross the blood-brain barrier more readily than regular magnesium ions, [2] although no credible evidence proving the claim exists. No biological mechanism is proposed how magnesium ions would overcome the rapid physiological redistribution after reaching the brain, justifying targeted delivery.

Weak evidence shows that magnesium L-threonate improves cognitive function in healthy adults, although the trial did not compare its efficacy against conventional magnesium formulations. [2]

References

  1. ↑ Gao Sheng-Li;Yang Xu-Wu;Chen San-Ping;Ju Zhan-Feng (2002). "Synthesis and Standard Enthalpy of Formation of Magnesium L-Threonate". Acta Phys. -Chim. Sin. 18 (11): 994–997. doi: 10.3866/PKU.WHXB20021107 .{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. 1 2 Zhang, Chengxiang; Hu, Qi; Li, Shifen; Dai, Feifei; Qian, Wen; Hewlings, Susan; Yan, Ting; Wang, Yubang (2022-12-08). "A Magtein®, Magnesium L-Threonate, -Based Formula Improves Brain Cognitive Functions in Healthy Chinese Adults". Nutrients. 14 (24): 5235. doi: 10.3390/nu14245235 . ISSN   2072-6643. PMC   9786204 . PMID   36558392.


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