Major facilitator superfamily domain containing 14a

MFSD14A
Identifiers
Aliases	MFSD14A , HIAT1, major facilitator superfamily domain containing 14A
External IDs	MGI: 1201609; HomoloGene: 22456; GeneCards: MFSD14A; OMA:MFSD14A - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p21.2 Start 100,038,095 bp [1] End 100,083,377 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 G1 Start 116,424,813 bp [2] End 116,456,326 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in smooth muscle tissue islet of Langerhans endometrium corpus callosum monocyte tibial arteries gonad right lung placenta C1 segment Top expressed in spermatocyte spermatid genital tubercle parotid gland seminal vesicula Epithelium of choroid plexus granulocyte lacrimal gland tail of embryo retinal pigment epithelium More reference expression data BioGPS n/a
Gene ontology Molecular function transporter activity Cellular component membrane integral component of membrane Biological process transmembrane transport acrosome assembly spermatogenesis spermatid development spermatid nucleus differentiation sperm mitochondrion organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64645 15247 Ensembl ENSG00000156875 ENSMUSG00000089911 UniProt Q96MC6 P70187 RefSeq (mRNA) NM_033055 NM_008246 RefSeq (protein) NP_149044 NP_032272 Location (UCSC) Chr 1: 100.04 – 100.08 Mb Chr 3: 116.42 – 116.46 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Major facilitator superfamily domain containing 14A (MFSD14A, HIAT1) is a protein that in humans is encoded by the MFSD14A gene. ^{[5] [6]} MFSD14A is an atypical solute carrier of MFS type. ^[7] HGNC:23363

MFSD14A cluster to AMTF1, together with MFSD9, MFSD10 and MFSD14B. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000156875 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000089911 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Major facilitator superfamily domain containing 14A".
6. Lekholm E, Perland E, Eriksson MM, Hellsten SV, Lindberg FA, Rostami J, Fredriksson R (2017-01-01). "Putative Membrane-Bound Transporters MFSD14A and MFSD14B Are Neuronal and Affected by Nutrient Availability". Frontiers in Molecular Neuroscience. 10: 11. doi: 10.3389/fnmol.2017.00011 . PMC   5263138 . PMID   28179877.
7. Perland E, Fredriksson R (March 2017). "Classification Systems of Secondary Active Transporters". Trends in Pharmacological Sciences. 38 (3): 305–315. doi:10.1016/j.tips.2016.11.008. PMID   27939446.
8. Perland E, Bagchi S, Klaesson A, Fredriksson R (September 2017). "Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression". Open Biology. 7 (9) 170142. doi:10.1098/rsob.170142. PMC   5627054 . PMID   28878041.