Michael P. O'Leary | |
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Born | 1952 Framingham, Massachusetts |
Education | |
Known for |
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Medical career | |
Profession | Surgeon |
Field | Urology |
Institutions | |
Sub-specialties | Male infertility, erectile dysfunction, benign prostate disease, stone disease |
Research |
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Michael P. O’Leary (born 1952) is an American urologist at Brigham and Women's Hospital in Boston, Massachusetts, professor of surgery at Harvard Medical School, and a former president and chair of the Boston Athletic Association. His work focuses on benign prostate disease, stone disease, male infertility and sexual dysfunction in men.
O'Leary's work has included developing patient-reported outcomes; a tool for measuring male sexual function, and for being named for a scale that measures lower urinary tract symptoms and their impact in people with interstitial cystitis.
Michael Philip O’Leary was born in Framingham, Massachusetts, to a lifelong Boston Athletic Association (BAA) member, who was also a former physician of Walter Brown. [1] [2] He completed his early education from Harvard College, where he was a track and cross country runner. [3] In 1978 he gained admission to the George Washington University School of Medicine, from where he graduated in 1980 and also received a Masters in Public Health from Harvard the same year [3] Between 1980 and 1982 he was resident at Tufts University School of Medicine, and then at Massachusetts General Hospital until 1987. [1] He received his board certificate in urology in 1990, after completing a fellowship at the University of California, San Francisco, School of Medicine and Stanford University School of Medicine the previous year. [3]
In 1989 O’Leary joined the BAA, that runs the annual Boston Marathon. [2] In 2013, he was at the finish line of the Boston Marathon bombing. [2] He was elected the BAA's president and Chair of the Board of Governors in 2017 for a six year term, having succeeded the BAA's first female president Joann Flaminio. [2] [4] [5] In 2023 his position as chair of the board of governors was succeeded by paralympic medallist Cheri Blauwet. [6]
O’Leary and colleagues developed the American Urologic Assoc Symptom Score for benign prostatic hyperplasia, also known as the International Prostate Symptom Score or IPSS. He is the principal author of the "Brief Male Sexual Function Inventory"; one patient-reported outcome tool used for measuring male sexual function. [7] [8] The questionnaire includes 11 items covering five parts; sexual desire, ejaculation, erection, perception of sexual function, and satisfaction with sex. [8] He is also a medical editor for the Harvard health report titled "What to Do about Erectile Dysfunction". [9] [10] In it, he wrote that erections "serve as a barometer", and problems with erections may indicate problems with the heart and blood vessels. [11] This he notes may be prevented by simple lifestyle changes like losing weight, exercising, and stopping smoking. [9] [10] The study was one of many that associate the ability to form an erection with cardiovascular health. [12]
O'Leary is named for the O'Leary-Sant Interstitial Cystitis Symptom Index, for measuring lower urinary tract symptoms and their impact in people with interstitial cystitis. [13] It looks at four main symptoms of interstitial cystitis and bladder pain syndrome; bladder pain, urgency, and frequency. [14]
O’Leary is married to Kathleen J. Welch, a retired anesthesiologist at Brigham and Women’s Hospital. [4] They live in Dedham, Massachusetts, [2] and have two children, Jacqueline, a marketing director for Dunkin' Donuts, [15] and James, a physician in vascular surgery at Boston’s Beth Israel Deaconess Hospital. [16] [17] [18]
Erectile dysfunction (ED), also referred to as impotence, is a form of sexual dysfunction in males characterized by the persistent or recurring inability to achieve or maintain a penile erection with sufficient rigidity and duration for satisfactory sexual activity. It is the most common sexual problem in males and can cause psychological distress due to its impact on self-image and sexual relationships.
Interstitial cystitis (IC), a type of bladder pain syndrome (BPS), is chronic pain in the bladder and pelvic floor of unknown cause. It is the urologic chronic pelvic pain syndrome of women. Symptoms include feeling the need to urinate right away, needing to urinate often, and pain with sex. IC/BPS is associated with depression and lower quality of life. Many of those affected also have irritable bowel syndrome and fibromyalgia.
Urology, also known as genitourinary surgery, is the branch of medicine that focuses on surgical and medical diseases of the urinary system and the reproductive organs. Organs under the domain of urology include the kidneys, adrenal glands, ureters, urinary bladder, urethra, and the male reproductive organs.
Prostatitis is an umbrella term for a variety of medical conditions that incorporate bacterial and non-bacterial origin illnesses in the pelvic region. In contrast with the plain meaning of the word, the diagnosis may not always include inflammation. Prostatitis is classified into acute, chronic, asymptomatic inflammatory prostatitis, and chronic pelvic pain syndrome.
Benign prostatic hyperplasia (BPH), also called prostate enlargement, is a noncancerous increase in size of the prostate gland. Symptoms may include frequent urination, trouble starting to urinate, weak stream, inability to urinate, or loss of bladder control. Complications can include urinary tract infections, bladder stones, and chronic kidney problems.
Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene. PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland in men and the paraurethral glands in women.
Sexual dysfunction is difficulty experienced by an individual or partners during any stage of normal sexual activity, including physical pleasure, desire, preference, arousal, or orgasm. The World Health Organization defines sexual dysfunction as a "person's inability to participate in a sexual relationship as they would wish". This definition is broad and is subject to many interpretations. A diagnosis of sexual dysfunction under the DSM-5 requires a person to feel extreme distress and interpersonal strain for a minimum of six months. Sexual dysfunction can have a profound impact on an individual's perceived quality of sexual life. The term sexual disorder may not only refer to physical sexual dysfunction, but to paraphilias as well; this is sometimes termed disorder of sexual preference.
Glomerulation refers to bladder hemorrhages which are thought to be associated with some types of interstitial cystitis (IC).
Bicalutamide, sold under the brand name Casodex among others, is an antiandrogen medication that is primarily used to treat prostate cancer. It is typically used together with a gonadotropin-releasing hormone (GnRH) analogue or surgical removal of the testicles to treat metastatic prostate cancer (mPC). To a lesser extent, it is used at high doses for locally advanced prostate cancer (LAPC) as a monotherapy without castration. Bicalutamide was also previously used as monotherapy to treat localized prostate cancer (LPC), but authorization for this use was withdrawn following unfavorable trial findings. Besides prostate cancer, bicalutamide is limitedly used in the treatment of excessive hair growth and scalp hair loss in women, as a puberty blocker and component of feminizing hormone therapy for transgender girls and women, to treat gonadotropin-independent early puberty in boys, and to prevent overly long-lasting erections in men. It is taken by mouth.
Prostatectomy is the surgical removal of all or part of the prostate gland. This operation is done for benign conditions that cause urinary retention, as well as for prostate cancer and for other cancers of the pelvis.
Nocturia is defined by the International Continence Society (ICS) as "the complaint that the individual has to wake at night one or more times for voiding ". The term is derived from Latin nox – "night", and Greek [τα] ούρα – "urine". Causes are varied and can be difficult to discern. Although not every patient needs treatment, most people seek treatment for severe nocturia, waking up to void more than 2 or 3 times per night.
Odynorgasmia, or painful ejaculation, also referred to as dysejaculation, dysorgasmia, and orgasmalgia, is a physical syndrome described by pain or burning sensation of the urethra or perineum during or following ejaculation. Causes include: infections associated with urethritis, prostatitis, epididymitis; use of anti-depressants; cancer of the prostate or of other related structures; calculi or cysts obstructing related structures; trauma to the region.
Transurethral microwave thermotherapy (TUMT) is one of a number of effective and safe procedures used in the treatment of lower urinary tract symptoms caused by benign prostatic hyperplasia. It is an alternative treatment to pharmacotherapy such as alpha blockers, transurethral resection of the prostate (TURP), transurethral needle ablation of the prostate, photoselective vaporization of the prostate and prostatic removal or prostatectomy.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS), previously known as chronic nonbacterial prostatitis, is long-term pelvic pain and lower urinary tract symptoms (LUTS) without evidence of a bacterial infection. It affects about 2–6% of men. Together with IC/BPS, it makes up urologic chronic pelvic pain syndrome (UCPPS).
Urologic diseases or conditions include urinary tract infections, kidney stones, bladder control problems, and prostate problems, among others. Some urologic conditions do not affect a person for that long and some are lifetime conditions. Kidney diseases are normally investigated and treated by nephrologists, while the specialty of urology deals with problems in the other organs. Gynecologists may deal with problems of incontinence in women.
William D. Steers was a Paul Mellon professor and chair of the Department of Urology at the University of Virginia School of Medicine. He was a president of the American Board of Urology (ABU) and editor of The Journal of Urology. In 2003, the University of Virginia awarded Steers the Hovey Dabney Professorship. In 2004, Dr. Steers initiated the Charlottesville Men's Four Miler road race to raise funds for men's health. Steers was a viticulturist, and co-owned Well Hung Vineyard in Charlottesville. He developed YOURometer, an iPhone app used to record urological related symptoms.
Eosinophilic cystitis is a rare type of interstitial cystitis first reported in 1960 by Edwin Brown. Eosinophilic cystitis has been linked to a number of etiological factors, including allergies, bladder tumors, trauma to the bladder, parasitic infections, and chemotherapy drugs, though the exact cause of the condition is still unknown. The antigen-antibody response is most likely the cause of eosinophilic cystitis. This results in the generation of different immunoglobulins, which activate eosinophils and start the inflammatory process.
The side effects of bicalutamide, a nonsteroidal antiandrogen (NSAA), including its frequent and rare side effects, have been well-studied and characterized. The most common side effects of bicalutamide monotherapy in men include breast tenderness, breast growth, feminization, demasculinization, and hot flashes. Less common side effects of bicalutamide monotherapy in men include sexual dysfunction, depression, fatigue, weakness, and anemia. Bicalutamide is well tolerated and has few side effects in women. General side effects of bicalutamide that may occur in either sex include diarrhea, constipation, abdominal pain, nausea, dry skin, itching, and rash.
Urologic chronic pelvic pain syndrome (UCPPS) is ongoing bladder pain in either sex, chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in men and interstitial cystitis or painful bladder syndrome (IC/PBS) in women.
Prostatic calculi (PC), prostatic stones, prostatic calcification or prostatic lithiasis, are hyper-echoic mineral deposits in the prostate that are frequently detected incidentally during transabdominal ultrasonography, transrectal ultrasonography, or computed tomography.