Microcin

Last updated
Subtilosin_A
PDB 1pxq EBI.jpg
structure of Subtilosin A
Identifiers
SymbolSubtilosin_A
Pfam PF11420
InterPro IPR021539
TCDB 1.C.84
OPM superfamily 379
OPM protein 1pxq
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary
Stainless steel sculpture based on the structure of the protein microcin J25. Author: Julian Voss-Andreae Nanos (Microcin J25).jpg
Stainless steel sculpture based on the structure of the protein microcin J25. Author: Julian Voss-Andreae

Microcins are very small bacteriocins, composed of relatively few amino acids. For this reason, they are distinct from their larger protein cousins. The classic example is microcin V, of Escherichia coli . Subtilosin A is another bacteriocin from Bacillus subtilis . The peptide has a cyclized backbone and forms three cross-links between the sulphurs of Cys13, Cys7 and Cys4 and the alpha-positions of Phe22, Thr28 and Phe31. [1]

Microcins produced by commensal E. coli strains target and eliminate enteric pathogens such as Salmonella enterica by mimicking the siderophores the pathogens use for iron scavenging. [2] Microcins also help commensal strains of E. coli outcompete pathogenic strains. [3]

BACTIBASE [4] [5] database is an open-access database for bacteriocins including microcins.

References

  1. Kawulka KE, Sprules T, Diaper CM, Whittal RM, McKay RT, Mercier P, Zuber P, Vederas JC (March 2004). "Structure of subtilosin A, a cyclic antimicrobial peptide from Bacillus subtilis with unusual sulfur to alpha-carbon cross-links: formation and reduction of alpha-thio-alpha-amino acid derivatives". Biochemistry. 43 (12): 3385–95. doi:10.1021/bi0359527. PMID   15035610.
  2. Huang, Kai; Zeng, Jianwei; Liu, Xueli; Jiang, Tianyu; Wang, Jiawei (2021). "Structure of the mannose phosphotransferase system (Man-PTS) complexed with microcin E492, a pore-forming bacteriocin". Cell Discovery. 7 (1): 20. doi:10.1038/s41421-021-00253-6. PMC   8021565 . PMID   33820910.
  3. Sassone-Corsi M, Nuccio SP, Liu H, Hernandez D, Vu CT, Takahashi AA; et al. (2016). "Microcins mediate competition among Enterobacteriaceae in the inflamed gut". Nature. 540 (7632): 280–283. Bibcode:2016Natur.540..280S. doi:10.1038/nature20557. PMC   5145735 . PMID   27798599.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  4. Hammami R, Zouhir A, Ben Hamida J, Fliss I (2007). "BACTIBASE: a new web-accessible database for bacteriocin characterization". BMC Microbiology. 7: 89. doi: 10.1186/1471-2180-7-89 . PMC   2211298 . PMID   17941971.
  5. Hammami R, Zouhir A, Le Lay C, Ben Hamida J, Fliss I (2010). "BACTIBASE second release: a database and tool platform for bacteriocin characterization". BMC Microbiology. 10: 22. doi: 10.1186/1471-2180-10-22 . PMC   2824694 . PMID   20105292.