Mir-605 microRNA precursor family

mir-605
Identifiers
Symbol	mir-605
Rfam	RF01011
miRBase family	MIPF0000528
Other data
RNA type	microRNA
Domain	Eukaryota;
PDB structures	PDBe

In molecular biology mir-605 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

p53 protein network

miR-605 is transcriptionally activated by the p53 protein through interaction with the promoter region of its gene. This microRNA in turn post-transcriptionally represses the oncoprotein and p53 suppressor Mdm2, which acts with p53 in a negative feedback loop in p53-wildtype cancers. Introduction of miR-605 interrupts this p53:Mdm2 interaction and instead there is a positive feedback loop in place, enabling rapid p53 accumulation in response to stress. Such p53 accumulation induces cell cycle arrest and apoptosis. ^[1]

See also

• MicroRNA

References

1. Xiao J, Lin H, Luo X, Luo X, Wang Z (2011). "miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress". EMBO J. 30 (3): 524–32. doi:10.1038/emboj.2010.347. PMC   3034018 . PMID   21217645.

Further reading

• Zhang, M.; Jin, M.; Yu, Y.; Zhang, S.; Wu, Y.; Liu, H.; Liu, H.; Chen, B.; Li, Q.; Ma, X.; Chen, K. (2012). "Associations of miRNA polymorphisms and female physiological characteristics with breast cancer risk in Chinese population". European Journal of Cancer Care. 21 (2): 274–280. doi: 10.1111/j.1365-2354.2011.01308.x . PMID   22074121.
• Zhang, M. W.; Jin, M. J.; Yu, Y. X.; Zhang, S. C.; Liu, B.; Jiang, X.; Pan, Y. F.; Li, Q. L.; Ma, X. Y.; Chen, K. (2011). "Associations of lifestyle-related factors, hsa-miR-149 and hsa-miR-605 gene polymorphisms with gastrointestinal cancer risk". Molecular Carcinogenesis. 51: E21 –E31. doi: 10.1002/mc.20863 . PMID   21976437. S2CID   221958071.
• Zhang, M. W.; Yu, Y. X.; Jin, M. J.; Pan, Y. F.; Jiang, X.; Li, Q. L.; Ma, X. Y.; Zhang, S. C.; Chen, K. (2011). "Association of miR-605 and miR-149 genetic polymorphisms with related risk factors of lung cancer susceptibility". Zhejiang da Xue Xue Bao. Yi Xue Ban = Journal of Zhejiang University. Medical Sciences. 40 (3): 265–271. doi:10.3785/j.issn.1008-9292.2011.03.006. PMID   21671485.
• Nymark, P.; Guled, M.; Borze, I.; Faisal, A.; Lahti, L.; Salmenkivi, K.; Kettunen, E.; Anttila, S.; Knuutila, S. (2011). "Integrative analysis of microRNA, mRNA and aCGH data reveals asbestos- and histology-related changes in lung cancer". Genes, Chromosomes and Cancer. 50 (8): 585–597. doi:10.1002/gcc.20880. PMID   21563230. S2CID   39556202.
• Scott, M. S.; Avolio, F.; Ono, M.; Lamond, A. I.; Barton, G. J. (2009). Unger, Ron (ed.). "Human miRNA Precursors with Box H/ACA snoRNA Features". PLOS Computational Biology. 5 (9) e1000507. Bibcode:2009PLSCB...5E0507S. doi: 10.1371/journal.pcbi.1000507 . PMC   2730528 . PMID   19763159.
• Lee, I.; Ajay, S. S.; Yook, J. I.; Kim, H. S.; Hong, S. H.; Kim, N. H.; Dhanasekaran, S. M.; Chinnaiyan, A. M.; Athey, B. D. (2009). "New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sites". Genome Research. 19 (7): 1175–1183. doi:10.1101/gr.089367.108. PMC   2704433 . PMID   19336450.

External links

• Page for mir-605 microRNA precursor family at Rfam