Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The signs and symptoms depend on the stage it presents: primary, secondary, latent or tertiary. The primary stage classically presents with a single chancre though there may be multiple sores. In secondary syphilis, a diffuse rash occurs, which frequently involves the palms of the hands and soles of the feet. There may also be sores in the mouth or vagina. Latent syphilis has no symptoms and can last years. In tertiary syphilis, there are gummas, neurological problems, or heart symptoms. Syphilis has been known as "the great imitator" because it may cause symptoms similar to many other diseases.
The Tuskegee Study of Untreated Syphilis in the Negro Male was a study conducted between 1932 and 1972 by the United States Public Health Service (PHS) and the Centers for Disease Control and Prevention (CDC) on a group of nearly 400 African American men with syphilis. The purpose of the study was to observe the effects of the disease when untreated, though by the end of the study medical advancements meant it was entirely treatable. The men were not informed of the nature of the experiment, and more than 100 died as a result.
Tuskegee University is a private, historically black land-grant university in Tuskegee, Alabama. It was founded on July 4th in 1881 by Lewis Adams and Booker T. Washington with help from the Alabama legislature via funding from two politicians seeking black votes.
Alfre Woodard is an American actress. Known for portraying strong-willed and dignified roles on stage and screen, she has received various accolades, including four Emmy Awards, a Golden Globe Award, and three Screen Actors Guild Awards as well as nominations for an Academy Award, BAFTA Award, and two Grammy Awards. In 2020, The New York Times ranked her as one of "The 25 Greatest Actors of the 21st Century". She is a board member of Academy of Motion Picture Arts and Sciences.
Thomas Parran was an American physician and Public Health Service officer. He was appointed the sixth Surgeon General of the United States from 1936 to 1948, and oversaw the notorious Tuskegee syphilis experiment and Guatemala syphilis experiment.
Obba Babatundé is an American actor. A native of Queens, New York City, he has appeared in more than seventeen stage productions, thirty theatrical films, sixty made-for-television films, and two prime-time series.
Robert Russa Moton was an American educator and author. He served as an administrator at Hampton Institute. In 1915 he was named principal of Tuskegee Institute, after the death of founder Booker T. Washington, a position he held for 20 years until retirement in 1935.
Neurosyphilis is the infection of the central nervous system in a patient with syphilis. In the era of modern antibiotics, the majority of neurosyphilis cases have been reported in HIV-infected patients. Meningitis is the most common neurological presentation in early syphilis. Tertiary syphilis symptoms are exclusively neurosyphilis, though neurosyphilis may occur at any stage of infection.
Fred David Gray is an American civil rights attorney, preacher, activist, and state legislator from Alabama. He handled many prominent civil rights cases, such as Browder v. Gayle, and was elected to the Alabama House of Representatives in 1970, along with Thomas Reed, both from Tuskegee. They were the first black state legislators in Alabama in the 20th century. He served as the president of the National Bar Association in 1985, and in 2001 was elected as the first African-American President of the Alabama State Bar.
The Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Television Movie or Limited Series is an award given by the Screen Actors Guild to honor the finest acting achievements in Miniseries or Television Movie.
The Tuskegee Airmen is a 1995 HBO television movie based on the exploits of an actual groundbreaking unit, the first African-American combat pilots in the United States Army Air Corps, that fought in World War II. The film was directed by Robert Markowitz and stars Laurence Fishburne, Cuba Gooding Jr., John Lithgow, and Malcolm-Jamal Warner.
Down in the Delta is a 1998 American-Canadian drama film, directed by Maya Angelou and starring Alfre Woodard, Al Freeman, Jr., Esther Rolle, Loretta Devine, and Wesley Snipes.
The Guatemala syphilis experiments were United States-led human experiments conducted in Guatemala from 1946 to 1948. The experiments were led by physician John Charles Cutler, who also participated in the late stages of the Tuskegee syphilis experiment. Doctors infected 1,300 people, including at least 600 soldiers and people from various impoverished groups with syphilis, gonorrhea, and chancroid, without the informed consent of the subjects. Only 700 of them received treatment. In total, 5,500 people were involved in all research experiments, of whom 83 died by the end of 1953, though it is unknown whether or not the injections were responsible for all these deaths. Serology studies continued through 1953 involving the same vulnerable populations in addition to children from state-run schools, an orphanage, and rural towns. However, the intentional infection of patients ended with the original study.
John Charles Cutler was a senior surgeon, and the acting chief of the venereal disease program in the United States Public Health Service. He is known for leading several controversial and unethical human experiments of syphilis, done under the auspices of the Public Health Service. He willfully spread syphilis and gonorrhea to unwitting patients including soldiers, prisoners, adults with leprosy, mental patients and orphan children as young as nine in the Guatemala syphilis experiments. He also conducted the Tuskegee syphilis experiments, in which African American men, not informed of the nature of the experiment, were deliberately denied treatment for syphilis.
The first recorded outbreak of syphilis in Europe occurred in 1494/1495 in Naples, Italy, during a French invasion. Because it was spread geographically by French troops returning from that campaign, the disease was known as "French disease", and it was not until 1530 that the term "syphilis" was first applied by the Italian physician and poet Girolamo Fracastoro. The causative organism, Treponema pallidum, was first identified by Fritz Schaudinn and Erich Hoffmann in 1905 at the Charité Clinic in Berlin. The first effective treatment, Salvarsan, was developed in 1910 by Sahachiro Hata in the laboratory of Paul Ehrlich. It was followed by the introduction of penicillin in 1943.
Eunice Verdell Rivers Laurie (1899–1986) was an African American nurse who worked in the state of Alabama. She is known for her work as one of the nurses of the U.S. Public Health Service Syphilis Study in Macon County from 1932 to 1972 which was "arguably the most infamous biomedical research study in U.S. history."
John Friend Mahoney was an American physician best known as a pioneer in the treatment of syphilis with penicillin. He won the 1946 Lasker Award.
John Roderick 'Rod' Heller, was the head in 1943–1948 of what was then called the "Venereal Disease" section of the United States Public Health Service (PHS). He then became the director of the National Cancer Institute, and then president/chief executive officer of the Memorial Sloan-Kettering Cancer Center in New York City.
Eugene Heriot Dibble Jr. (1893–1968) was an American physician and head of the John A. Andrew Memorial Hospital at the Tuskegee Institute in Alabama. He played an important role in the Tuskegee Syphilis Study, which was a clinical study conducted on syphilis in African American males from 1932 to 1972.
