Interstate 35 (I-35) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route. It stretches from Laredo, Texas, near the Mexican border to Duluth, Minnesota, at Minnesota State Highway 61 and 26th Avenue East. The highway splits into I-35E and I-35W in two separate places, the Dallas–Fort Worth metroplex in Texas and at the Minnesota twin cities of Minneapolis–Saint Paul.
U.S. Route 400 is a 481.306-mile-long (774.587 km) mostly east–west U.S. Highway, commissioned in 1994. The highway's western terminus is in Granada, Colorado, at an intersection with US 385. The highway's eastern terminus is southwest of Joplin, Missouri, near Loma Linda, at an interchange with Interstate 44, with which it shares with US 166. It originally ended in Garden City, Kansas; in 1996 it was extended to its current western terminus.
U.S. Route 79 is a United States highway in the Southern United States. The route is officially considered and labeled as a north–south highway, but its path is actually more of a diagonal northeast–southwest highway. The highway's northern/eastern terminus is in Russellville, Kentucky, at an intersection with U.S. Route 68 and KY 80. Its southern/western terminus is in Round Rock, Texas, at an interchange with Interstate 35, ten miles (16 km) north of Austin. US 79, US 68, and Interstate 24/US 62 are the primary east–west access points for the Land Between the Lakes recreation area straddling the Kentucky/Tennessee border.
U.S. Route 160 (US 160) is a 1,465-mile-long (2,358 km) east–west United States Numbered Highway in the Midwestern and Western United States. The western terminus of the route is at US 89 five miles (8.0 km) west of Tuba City, Arizona. The eastern terminus is at US 67 and Missouri 158 southwest of Poplar Bluff, Missouri. Its route, if not its number, was made famous in song in 1975, as the road from Wolf Creek Pass to Pagosa Springs, Colorado in C.W. McCall's country music song "Wolf Creek Pass".
U.S. Route 24 or U.S. Highway 24 (US 24) is one of the original United States Numbered Highways of 1926. It originally ran from Pontiac, Michigan, in the east to Kansas City, Missouri, in the west. Today, the highway's eastern terminus is in Independence Township, Michigan, at an intersection with Interstate 75 (I-75), and its western terminus is near Minturn, Colorado, at an intersection with I-70. The highway transitions from north–south to east–west signage at the Ohio–Michigan state line.
U.S. Route 71 or U.S. Highway 71 is a major north–south United States highway that extends for over 1500 miles (2500 km) in the central United States. This original 1926 route has remained largely unchanged by encroaching Interstate highways. Currently, the highway's northern terminus is in International Falls, Minnesota at the Canada–US border, at the southern end of the Fort Frances-International Falls International Bridge to Fort Frances, Ontario. U.S. Route 53 also ends here. On the other side of the bridge, Trans-Canada Highway is an east–west route while Ontario Highway 71 is a north–south route. US 71's southern terminus is between Port Barre and Krotz Springs, Louisiana at an intersection with U.S. Route 190. For the entirety south of Kansas City, Missouri, US 71 runs parallel and concurrent with the existing and future Interstate 49. North of Kansas City, US 71 runs halfway between Interstate 29 and Interstate 35, which they split in the city at an interchange with Interstate 70.
U.S. Route 166 (US 166) is a 164-mile (264 km) east–west United States highway. This route and US 266 are the only two remaining spurs of historic U.S. Route 66, since US 666 was renumbered to US 491 in 2003.
U.S. Route 54 is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville, Illinois. The Union Pacific Railroad's Tucumcari Line runs parallel to US 54 from El Paso to Pratt, Kansas, which comprises about two-thirds of the route. Truckers refer to this road as "The Bee Line."
U.S. Route 56 is an east–west United States highway that runs for approximately 640 miles (1,030 km) in the Midwestern United States. US 56's western terminus is at Interstate 25 Business, US 412 and New Mexico State Road 21 in Springer, New Mexico and the highway's eastern terminus is at US 71 in Kansas City, Missouri. Much of it follows the Santa Fe Trail.
Route 96 is a state highway that travels from Route 171 near Carl Junction, in Jasper County, to Interstate 44 (I-44) in Halltown, in Lawrence County. A large section of the highway between Carthage and Halltown served as part of U.S. Route 66 (US 66) and is currently marked as Historic Route 66.
Route 13 is a highway in Missouri which runs almost the entire north–south length of the state. Its northern terminus is at U.S. Route 69/136 in Bethany. Its southern terminus is at the Arkansas state line in downtown Blue Eye, Missouri–Arkansas where it continues as Highway 21. It is one of the original state highways of Missouri.
Route 571 is a two-lane highway in Carthage, Missouri, replacing a former section of U.S. Route 71 Alternate (US 71 Alt.) with the realignment of US 71. Both termini are at Interstate 49 (I-49) and US 71; its northern terminus is Business I-49 and Route 171 at the western edge of Carthage and its southern terminus is I-49/US 71 at the southern edge of Carthage.
Route 7 is a state highway with its northern terminus at U.S. Route 24 in northeast Independence and its southern terminus at Interstate 44 southeast of Richland. The section between Harrisonville and Clinton provides an important link for traffic between Springfield and Kansas City.
K-96 is a 300-mile-long (480 km) state highway in central and southern Kansas. Its western terminus is at the Colorado state line east of Towner, Colorado, where it continues as Colorado State Highway 96; its eastern terminus since 1999 is at U.S. Route 54/U.S. Route 400 in eastern Wichita.
Interstate 44 (I-44) in the US state of Missouri runs northeast from the Oklahoma state line near Joplin to I-70 in Downtown St. Louis. It runs for about 293 miles (472 km) in the state, and is the longest Interstate Highway in the state.
A total of ten special routes of U.S. Route 71 exist, and another ten previously existed.
U.S. Route 71 (US 71) is a major north–south U.S. Highway that runs from Louisiana to Canada. US 71 enters Missouri from Arkansas in the town of Jane. US 71 serves the cities of Joplin, Kansas City and St. Joseph. At noon on December 12, 2012, the section of US 71 between Pineville, Missouri and I-435 in south Kansas City was also designated as a northern extension of Interstate 49 (I-49).
U.S. Route 169 (US-169) is a major north–south U.S. Highway that runs from US-64 in Tulsa, Oklahoma, to US-53 near Virginia, Minnesota. In Kansas, the highway is a main north–south route that runs through the eastern end of the state from the Oklahoma border to Missouri border. Along the way US-169 intersects several major highways including US-400 by Cherryvale, US-54 by Iola, overlaps US-59 south of Garnett, overlaps I-35 from Olathe to Merriam, and in Kansas City begins an overlap with I-70, US-24 and US-40 which it follows into Missouri.
U.S. Route 54 is a part of the U.S. Highway System that runs from El Paso, Texas, to Interstate 72 (I-72) in Griggsville, Illinois. In the U.S. state of Kansas, US 54 is a main east–west highway that runs from the Oklahoma border east to the Missouri border.
Four business routes of Interstate 49 (I-49) exist, all of them within the state of Missouri. All four were once business routes of U.S. Route 71 (US 71) and were converted to business routes of I-49 on December 12, 2012, when that highway was designated in Missouri.
I-49 / US 71 / Route 96 / Route 571 in Carthage 
K-171 near Opolis, KS 
