Interstate 44 (I-44) is an Interstate Highway in the central United States. Although it is nominally an east–west road as it is even-numbered, it follows a more southwest–northeast alignment. Its western terminus is in Wichita Falls, Texas, at a concurrency with U.S. Route 277 (US 277), US 281, and US 287; its eastern terminus is at I-70 in St. Louis, Missouri. I-44 is one of five Interstates built to bypass US 66; this highway covers the section between Oklahoma City and St. Louis. Virtually the entire length of I-44 east of Springfield, Missouri, was once US 66, which was upgraded from two to four lanes from 1949 to 1955. The section of I-44 west of Springfield was built farther south than US 66 in order to connect Missouri's section with the already completed Will Rogers Turnpike, which Oklahoma wished to carry their part of I-44.
U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel.
U.S. Route 160 (US 160) is a 1,465-mile-long (2,358 km) east–west United States Numbered Highway in the Midwestern and Western United States. The western terminus of the route is at US 89 five miles (8.0 km) west of Tuba City, Arizona. The eastern terminus is at US 67 and Missouri 158 southwest of Poplar Bluff, Missouri. Its route, if not its number, was made famous in song in 1975, as the road from Wolf Creek Pass to Pagosa Springs, Colorado in C.W. McCall's country music song "Wolf Creek Pass".
U.S. Route 166 (US 166) is a 164-mile (264 km) east–west United States highway. This route and US 266 are the only two remaining spurs of historic U.S. Route 66, since US 666 was renumbered to US 491 in 2003.
Route 66 is a fourteen-mile (21 km) long road in southwest Missouri, USA, which had previously been U.S. Route 66 for its final six years. The highway begins at Interstate 44, passes through Duenweg, Duquesne, and Joplin, then crosses into Kansas becoming K-66.
Route 96 is a state highway that travels from Route 171 near Carl Junction, in Jasper County, to Interstate 44 (I-44) in Halltown, in Lawrence County. A large section of the highway between Carthage and Halltown served as part of U.S. Route 66 (US 66) and is currently marked as Historic Route 66.
Route 86 is a highway in southwest Missouri. The eastern terminus is at U.S. Route 65 just north of Ridgedale. From there, the road crosses the Long Creek arm of Table Rock Lake and continues to Blue Eye west between the Arkansas state line on the south and Table Rock Lake on the north. This section is also in the Mark Twain National Forest, and is recommended as a scenic drive by the Missouri Department of Transportation. From Eagle Rock the road turns north to join with Route 76 at Bates Corner with which it is runs concurrent through Cassville to just east of Rocky Comfort. The road continues north and west towards Neosho, then goes further west before turning north towards Joplin where the road ends at the interchange of Interstate 44 and Route 43. Except for a short section in Neosho, the road is a two-lane highway for its entire length.
Route 90 is a highway in southwest Missouri. Its eastern terminus is at Route 37 in Washburn; its western terminus is at Route 43 northeast of Southwest City.
Route 37 is a highway in southwest Missouri. Its northern terminus is at U.S. Route 160 in Golden City ; its southern terminus is at the Arkansas state line where it continues as Highway 37, though it only runs very briefly before ending at U.S. Route 62 in Gateway, Arkansas.
Arkansas Highway 43 (AR 43) is a designation for three state highways in Arkansas. One segment runs from Highway 264 in Siloam Springs north to the Missouri state line. A second segment of 29.5 miles (47.5 km) runs from Highway 21 at Boxley north to Highway 7 in Harrison. A third segment runs 1.8 miles (2.9 km) in Harrison from U.S. Route 65 (US 65) east to Highway 7.
State Highway 20 is a highway in northeastern Oklahoma. Its eastern terminus is at the Missouri state line; its western terminus is at SH-18 near Ralston. The highway runs a total length of 142.7 miles (229.7 km). It has no lettered spur routes.
State Highway 4, abbreviated as SH-4 or OK-4, is a designation for two distinct highways maintained by the U.S. state of Oklahoma. One of them serves as an important route through the suburbs west of Oklahoma City, while the other connects US-259 to the Arkansas state line west of Cove, Arkansas. SH-4 has no lettered spur routes.
State Highway 10 is a state highway in northeastern Oklahoma. It makes a 233.1 miles (375.1 km) crescent through the northeast corner of the state, running from SH-99 in Osage County to Interstate 40 (I-40) near Gore. It has two lettered spur routes.
U.S. Route 69 is a major north-south U.S. Highway in the U.S. state of Oklahoma. It extends the corridor formed by U.S. Route 75 in Texas, from Dallas northeast via McAlester and Muskogee to the Will Rogers Turnpike near Vinita. From Vinita to the Kansas state line, US-69 generally parallels the turnpike along old U.S. Highway 66.
U.S. Highway 59 (US-59) heads along the eastern portion of the state of Oklahoma. US-59's 216.47-mile (348.37 km) route through Oklahoma takes it through the mountainous terrain of the eastern Oklahoma Ouachitas and Ozarks. US-59 serves several lakes and towns through Oklahoma's Green Country, including Grand Lake, a major recreation center. The route enters the state from Arkansas near Fogel, Arkansas, and ends at the Kansas state line south of Chetopa, Kansas.
U.S. Route 60 (US-60) is a transcontinental U.S. highway extending from near Brenda, Arizona to Virginia Beach, Virginia on the Atlantic Ocean. Along the way, 352.39 miles (567.12 km) of the route lies within the state of Oklahoma. The highway crosses into the state from Texas west of Arnett and serves many towns and cities in the northern part of the state, including Arnett, Seiling, Fairview, Enid, Ponca City, Pawhuska, Bartlesville, and Vinita. US-60 exits Oklahoma near Seneca, Missouri. In Oklahoma, US-60 has three business routes, serving Tonkawa, Ponca City, and Seneca. The first 60.2 miles (96.9 km) of the route, from the Texas line to Seiling, is also designated as State Highway 51 (SH-51).
U.S. Route 412 is a U.S. highway in the south-central portion of the United States, connecting Springer, New Mexico to Columbia, Tennessee. A 504.11-mile (811.29 km) section of the highway crosses the state of Oklahoma, traversing the state from west to east. Entering the state southwest of Boise City, US-412 runs the length of the Oklahoma Panhandle and serves the northern portion of the state's main body, before leaving the state at West Siloam Springs. Along the way, the route serves many notable cities and towns, including Boise City, Guymon, Woodward, Enid, and the state's second-largest city, Tulsa.
U.S. Route 64 (US-64) is a U.S. highway running from the Four Corners area to the Outer Banks of North Carolina. Between these two points, the highway passes through the entire width of Oklahoma; a total of 591.17 miles (951.40 km) of US-64 lies in the state of Oklahoma. US-64 enters the state from New Mexico, crossing the line between the two states between Clayton, New Mexico, and Boise City in Cimarron County. The route runs the full length of the Oklahoma Panhandle, then serves the northernmost tier of counties in the main body of the state before dipping southeastward to Tulsa, the state's second-largest city. From Tulsa, the highway continues southeast, leaving Oklahoma just west of Fort Smith, Arkansas. In addition to Tulsa, US-64 serves fifteen Oklahoma counties and the cities of Guymon, Woodward, Enid, and Muskogee.
U.S. Route 67 is the portion of a north-south highway in Missouri that starts at the Arkansas state line south of Neelyville and ends at the Illinois state line northeast of West Alton.
U.S. Route 60 (US 60) is a part of the United States Numbered Highway System that runs from Brenda, Arizona, east to Virginia Beach, Virginia. In the state of Missouri, US 60 is a main east–west highway that runs through the southern part of the state, from the Oklahoma border to the Illinois border.
AR 43 / SH-20 at the Arkansas/Oklahoma state line
US 54 in Vernon County 
