Interstate 49 (I-49) is a north–south Interstate Highway with multiple segments. The original portion is entirely within Louisiana with an additional signed portion extending from I-220 in Shreveport to the Arkansas state line, three newer sections are in Arkansas, and one section in Missouri. Its southern terminus is in Lafayette, Louisiana, at I-10 while its northern terminus is in Kansas City, Missouri, at I-435 and I-470. Future plans include portions of the remaining roadway in Louisiana, Arkansas, and Texas, to link Kansas City, Missouri with New Orleans.
U.S. Route 71 or U.S. Highway 71 is a major north–south United States highway that extends for over 1500 miles (2500 km) in the central United States. This original 1926 route has remained largely unchanged by encroaching Interstate highways. Currently, the highway's northern terminus is in International Falls, Minnesota at the Canada–US border, at the southern end of the Fort Frances-International Falls International Bridge to Fort Frances, Ontario. U.S. Route 53 also ends here. On the other side of the bridge, Trans-Canada Highway is an east–west route while Ontario Highway 71 is a north–south route. US 71's southern terminus is between Port Barre and Krotz Springs, Louisiana at an intersection with U.S. Route 190. For the entirety south of Kansas City, Missouri, US 71 runs parallel and concurrent with the existing and future Interstate 49. North of Kansas City, US 71 runs halfway between Interstate 29 and Interstate 35, which they split in the city at an interchange with Interstate 70.
Route 164 is a state highway in the Missouri Bootheel. The route starts at U.S. Route 412 in Cardwell. The route travels eastward across the bootheel, and it goes through the towns of Arbyrd, Hornersville, Rives, and Steele. It becomes concurrent with US 61 briefly in Steele, and intersects Interstate 55 (I-55) east of the city. The route ends east of Cottonwood Point, near the Mississippi River.
Route 108 is a short highway in the Bootheel of southeastern Missouri. Its eastern terminus is the Arkansas state line at Arkansas Highway 77, about six miles (10 km) south of Arbyrd, the only town on the route. Its western terminus is at U.S. Route 412 (US 412) about two miles (3 km) north of Arbyrd. Although signed as an east–west route, the route follows mostly north–south roadways. The route was designated in 1930, and was extended east in 1972.
Route 246 is a 15.002-mile-long (24.143 km) east–west highway in extreme northern Missouri. The western terminus is at Route 148 in Hopkins. The route travels eastward to supplemental Route E, where it becomes concurrent and starts traveling south. It then continues east to its terminus at Route 46 east of Sheridan. Formerly a spur route of Route 46 and supplemental Route D, Route 246 was designated around 1954, and was extended west to Hopkins in 1955.
Route 16 is a 16.709-mile-long (26.891 km) highway in Lewis County, Missouri. The western terminus is at Route 6 east of Lewistown. The route travels eastward, through Monticello and over a few rivers. Route 16 then intersects U.S. Route 61. The route ends at US 61 Business and Route B in Canton. The road was formerly part of Route 6, but it was rerouted in 1931. The old alignment was renumbered Route 96 that year. Ten years later, the route was renumbered to Route 16.
Route 102 is a highway in southeastern Missouri. The route starts at Route 105 near East Prairie. It travels southeastwards through farmland to Big Oak Tree State Park. The road then turns east past the entrance to the park, and ends at its eastern terminus at Route 77 in Dorena. The route was designated in 1940, as a road from the state park to a supplemental route. Route 102 replaced a large section of the supplemental route in 1961, and then was extended eastwards to a new terminus at Route 77 in 1994.
Route 162 is a state highway in the Missouri Bootheel. Its western terminus is at Route 25 in Clarkton, Dunklin County, and the route travels eastward to nearby towns of Gideon and Portageville, where it intersects U.S. Route 61 and Interstate 55 (I-55). The road then continues through rural New Madrid County and ends at a boat ramp near the Mississippi River.
Route 103 is a short highway in southeastern Missouri. Its southern terminus is at Route Z inside the Ozark National Scenic Riverways. The route travels north and intersects a few county roads as it leaves the national park. The road ends at U.S. Route 60 in a three-way junction. After being proposed in 1930, a road was built from the national park to US 60 in 1933. The gravel road was designated as Route 103, and it was paved five years later.
Route 48 is a state highway in northwestern Missouri. Its western terminus is located at U.S. Route 71 north of Savannah. The route travels eastward across the communities of Rosendale, Rea, and Whitesville. The road ends at US 169 in King City, about 20 miles (32 km) from its western terminus. The road was designated around 1926, and was completely laid down with gravel by 1936 and paved in asphalt by 1942.
Route 75 is a short highway in Mississippi County in the U.S. state of Missouri. Its southern terminus is at Route 80, and it travels north through farmland to the town of Anniston. It then travels westward to its northern terminus at Route 105 north of East Prairie. The route was designated in 1968, after Route 77 was moved to a new alignment east of Anniston, and the remaining section was renumbered to Route 75.
Route 144 is a 2.956-mile-long (4.757 km) state route in Ste. Genevieve County, Missouri. Its western terminus is at Route 32 near the village of Millers. The route travels southeastward toward Hawn State Park. The road then turns east and ends at Bauer Road and Park Drive, inside the state park. The route was designated in 1972, and has kept the same alignment since.
K-126 is a 26.918-mile-long (43.320 km) mostly east–west state highway located entirely within Crawford County in southeastern Kansas. Its western terminus is at U.S. Route 400 (US-400) just south of McCune, and its eastern terminus is the Missouri state line where it continues as Route 126. Along the way the highway passes through the city of McCune and also the city of Pittsburg, where it intersects US-69 and US-160.
Highway 21 is a north–south state highway in north central Arkansas. The route of 99.14 miles (159.55 km) runs from US Route 64 (US 64) in Clarksville north across US 62 to Missouri Route 13 at the Missouri state line The route is a two-lane highway with the exception of a brief concurrency with US 62, a four-lane highway, in Berryville.
Arkansas Highway 151 is a designation for two north–south state highways in Mississippi County, Arkansas. An eastern route of 5.75 miles (9.25 km) runs from Highway 148 north to Highway 18. A second route of 6.65 miles (10.70 km) begins at U.S. Route 78 (US 78)/Highway 18 in Blytheville and runs north to Missouri supplemental route TT (SSR-TT) at the Missouri state line. A third route was dedicated in May 2013 and begins at State Line Avenue in Texarkana and continues east to Interstate 49 (I-49)/US 71.
Route 84 is a state highway in the Missouri bootheel. The route starts at Arkansas Highway 90 over the St. Francis River on the Arkansas–Missouri state line. The road travels eastward to Kennett, where it becomes concurrent with U.S. Route 412. East of Kennett, the concurrent routes travel eastward on a divided highway to Hayti Heights, where the concurrency ends. Route 84 travels through Hayti Heights and Hayti, and it crosses Interstate 55 (I-55) and US 61. The route then travels southeastwards to Caruthersville, and bypasses the central area of the city. In the southern part of Caruthersville, Route 84 ends at an interchange with I-155 and US 412.
Highway 38 is a designation for three state highways in Arkansas. One route of 49.58 miles (79.79 km) runs east from Highway 367 at Cabot to US Route 49 (US 49) near Hunter. A second route of 21.43 miles (34.49 km) begins at Interstate 40 (I-40) and runs east to Highway 147 near Horseshoe Lake. A third route of 0.10 miles (0.16 km) runs in West Memphis as Martin Luther King Jr. Drive from US 70 north to I-55/US 61/US 64/US 79. All routes are maintained by the Arkansas State Highway and Transportation Department (AHTD).
U.S. Highway 71 is a U.S. highway that runs from Krotz Springs, LA to the Fort Frances–International Falls International Bridge at the Canadian border. In Arkansas, the highway runs from the Louisiana state line near Doddridge to the Missouri state line near Bella Vista. In Texarkana, the highway runs along State Line Avenue with US 59 and partially runs in Texas. Other areas served by the highway include Fort Smith and Northwest Arkansas.
Mississippi Highway 473 is a short highway in central Mississippi. Its southern terminus is at the Hinds–Copiah county line. The route travels north to Terry, and turns west. MS 473 enters Terry, and ends at Interstate 55 (I-55) and U.S. Route 51. The route was designated in 1957, from MS 27 to US 51. MS 473 was removed from the state highway system in 1967. It was restored into the system in 1995, from the county line to I-55/US 51.
K-126 at the Kansas state line
I-49 / US 71 near Jasper 
US 160 / Route 37 in Golden City 
