U.S. Route 61 or U.S. Highway 61 (U.S. 61) is a major United States highway that extends 1,400 miles (2,300 km) between New Orleans, Louisiana and the city of Wyoming, Minnesota. The highway generally follows the course of the Mississippi River and is designated the Great River Road for much of its route. As of 2004, the highway's northern terminus in Wyoming, Minnesota, is at an intersection with Interstate 35 (I-35). Until 1991, the highway extended north on what is now Minnesota State Highway 61 through Duluth to the Canada–U.S. border near Grand Portage. Its southern terminus in New Orleans is at an intersection with U.S. Route 90. The route was an important south–north connection in the days before the interstate highway system.
U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel.
U.S. Route 67 is a major north–south U.S. highway which extends for 1,560 miles (2,511 km) in the Central United States. The southern terminus of the route is at the United States-Mexico border in Presidio, Texas, where it continues south as Mexican Federal Highway 16 upon crossing the Rio Grande. The northern terminus is at U.S. Route 52 in Sabula, Iowa. US 67 crosses the Mississippi River twice along its routing. The first crossing is at West Alton, Missouri, where US 67 uses the Clark Bridge to reach Alton, Illinois. About 240 miles (390 km) to the north, US 67 crosses the river again at the Rock Island Centennial Bridge between Rock Island, Illinois, and Davenport, Iowa. Additionally, the route crosses the Missouri River via the Lewis Bridge a few miles southwest of the Clark Bridge.
U.S. Route 71 or U.S. Highway 71 is a major north–south United States highway that extends for over 1500 miles (2500 km) in the central United States. This original 1926 route has remained largely unchanged by encroaching Interstate highways. Currently, the highway's northern terminus is in International Falls, Minnesota at the Canada–US border, at the southern end of the Fort Frances-International Falls International Bridge to Fort Frances, Ontario. U.S. Route 53 also ends here. On the other side of the bridge, Trans-Canada Highway is an east–west route while Ontario Highway 71 is a north–south route. US 71's southern terminus is between Port Barre and Krotz Springs, Louisiana at an intersection with U.S. Route 190. For the entirety south of Kansas City, Missouri, US 71 runs parallel and concurrent with the existing and future Interstate 49. North of Kansas City, US 71 runs halfway between Interstate 29 and Interstate 35, which they split in the city at an interchange with Interstate 70.
U.S. Route 63 (US 63) is a 1,286-mile (2,070 km), north–south United States Highway primarily in the Midwestern and Southern United States. The southern terminus of the route is at Interstate 20 (I-20) in Ruston, Louisiana; the northern terminus is at US 2 eight miles (13 km) west of Ashland, Wisconsin.
Route 14 is a state highway traveling through the southern part of the U.S. state of Missouri. Its western terminus is at U.S. Route 60 (US 60) in Marionville, and its eastern terminus is at US 63 on the northern edge of West Plains. Route 14 is a two-lane highway for its entire length, however, there are plans to widen Route 14 in some spots.
Arkansas Highway 25 is a northeast–southwest state highway in north central Arkansas. The route runs 85.66 miles (137.86 km) from US 64 in Conway to US 63/412 in Black Rock through Greers Ferry, Batesville, and the foothills of The Ozarks.
State Highway 10 is a state highway in northeastern Oklahoma. It makes a 233.1 miles (375.1 km) crescent through the northeast corner of the state, running from SH-99 in Osage County to Interstate 40 (I-40) near Gore. It has two lettered spur routes.
Highway 77 is a north–south state highway in Northeast Arkansas. The route of 66.70 miles (107.34 km) runs from US Highway 70 (US 70) in West Memphis north through small towns and agricultural areas of the Arkansas Delta to the Missouri state line. It is generally a low-traffic road except in West Memphis. Created during the 1926 Arkansas state highway numbering, the route was extended in the 1950s and 1960s, including along a former alignment of US 61. AR 77 does not have any spur or business routes.
Interstate 44 (I-44) in the US state of Missouri runs northeast from the Oklahoma state line near Joplin to I-70 in Downtown St. Louis. It runs for about 293 miles (472 km) in the state, and is the longest Interstate Highway in the state.
U.S. Route 65 is a north–south U.S. highway that runs from Clayton, Louisiana to Albert Lea, Minnesota. In Missouri, the highway enters the state from Arkansas, just south of Branson. The highway exits the state into Iowa near South Lineville.
U.S. Highway 65 (US 65) runs north–south through southeastern and north central Arkansas for 309.52 miles (498.12 km). US 65 enters the state from Louisiana south of Eudora, running concurrently with the Great River Road. The route exits into Missouri northwest of Omaha. US 65 runs through the major cities of Pine Bluff and Little Rock.
U.S. Highway 63 is a north-south U.S. highway that begins in Ruston, LA. In the US state of Arkansas the highway enters the state from Louisiana concurrent with US 167 in Junction City. The highway runs north through the eastern part of the state, serving rural areas of South Arkansas and the Arkansas Delta, as well as Pine Bluff and Jonesboro. The highway exits the state at Mammoth Spring traveling into Missouri.
Highway 14 is an east–west state highway in Arkansas. The route of 227.35 miles (365.88 km) begins at Boat Dock Road near Table Rock Lake and runs east to Mississippi County Route W1020 (CR W1020) at Golden Lake. Segments of the highway are part of two Arkansas Scenic Byways: Sylamore Scenic Byway in the Ozark National Forest and the Crowley's Ridge Parkway atop Crowley's Ridge.
U.S. Route 62 is a U.S. highway running from El Paso, Texas northeast to Niagara Falls, New York. In the U.S. state of Arkansas, the route runs 329.9 miles from the Oklahoma border near Summers east to the Missouri border in St. Francis, serving the northern portion of the state. The route passes through several cities and towns, including Fayetteville, Springdale, Bentonville, Harrison, Mountain Home, Pocahontas, and also Piggott. US 62 runs concurrent with several highways in Arkansas including Interstate 49 and U.S. Route 71 between Fayetteville and Bentonville, U.S. Route 412 through much of the state, U.S. Route 65 in the Harrison area, and with U.S. Route 63 and U.S. Route 67 in northeast Arkansas.
A total of eight special routes of U.S. Route 65 exist, divided between the U.S. states of Arkansas and Missouri. Currently, they are all business loops, although a spur route in Pine Bluff, Arkansas and bypass routes in Baton Rouge, Louisiana and Springfield, Missouri both existed in the past.
Six special routes of U.S. Route 412 exist.
Highway 95 is a designation for a north–south state highway in north central Arkansas. The route runs 49.40 miles (79.50 km) runs north from US Highway 64 and Highway 113 in Morrilton north to Highway 330.
U.S. Highway 71 is a U.S. highway that runs from Krotz Springs, LA to the Fort Frances–International Falls International Bridge at the Canadian border. In Arkansas, the highway runs from the Louisiana state line near Doddridge to the Missouri state line near Bella Vista. In Texarkana, the highway runs along State Line Avenue with US 59 and partially runs in Texas. Other areas served by the highway include Fort Smith and Northwest Arkansas.
U.S. Route 63 is the portion of a north-south highway that runs through the U.S. state of Missouri from the Arkansas state line near Thayer to the Iowa state line near Lancaster.
AR 125 at the Arkansas state line
US 65 / Route CC at Fair Grove 
