U.S. Route 65 is a north–south United States highway in the southern and midwestern United States. The southern terminus of the route is at U.S. Route 425 in Clayton, Louisiana. The northern terminus is at Interstate 35 just south of Interstate 90 in Albert Lea, Minnesota. Parts of its modern route in Iowa and historic route in Minnesota follow the old Jefferson Highway.
Route 364, known locally as the Page Extension, the Page Avenue Freeway, the Page Expressway, or simply the Extension, is a freeway that connects St. Louis County in Maryland Heights with St. Charles County in Lake St. Louis via the Veterans Memorial Bridge over the Missouri River. The highway is a designated auxiliary state route of I-64.
Missouri Route 370 (Route 370) is a freeway that connects St. Louis County with St. Charles County via the Discovery Bridge over the Missouri River. The St. Charles County segment of the freeway is signed as the Patrick J. Bray Memorial Highway while in St. Louis County it is signed as the Officer Scott H. Armstrong Memorial Highway.
Route 215 is a highway in southern Missouri. Its northern terminus is at Route 39 south of Stockton; its southern terminus is at U.S. Route 65 between Buffalo and Springfield. Except for a short section which overlaps Route 13, it is a two-lane highway its entire length. It was originally a set of supplemental routes. In the early 2000s, US 65 was realigned and the southern terminus was extended about one mile (1.6 km) east opposite the western terminus of Route O. The highway runs more east–west than north–south, but is marked as a north–south highway.
Route 13 is a highway in Missouri which runs almost the entire north–south length of the state. Its northern terminus is at U.S. Route 69/136 in Bethany. Its southern terminus is at the Arkansas state line in downtown Blue Eye, Missouri–Arkansas where it continues as Highway 21. It is one of the original state highways of Missouri.
Route 76 is a highway in the west half of southern Missouri running between U.S. Route 60 and U.S. Route 63 at Willow Springs and the Oklahoma state line near Tiff City where it continues as a county road. It bypasses Branson on the Ozark Mountain High Road and is the namesake of the Branson strip, 76 Country Blvd. The road runs for its entirety through the Missouri Ozarks, and is at times very hilly and curvy.
Route 7 is a state highway with its northern terminus at U.S. Route 24 in northeast Independence and its southern terminus at Interstate 44 southeast of Richland. The section between Harrisonville and Clinton provides an important link for traffic between Springfield and Kansas City.
Route 765 is a short state highway in Sedalia, Missouri, in Pettis County. The route begins at an interchange with Limit Avenue in Sedalia. The route runs eastward along West Main Street and north along North Ohio Avenue through downtown Sedalia. The route as it approaches its northern terminus becomes rural, after being primarily commercial and residential. Route 765's northern terminus is at an interchange with US 65's freeway segment. The last distance to the northern terminus is one-way, with northbound Route 765 merging into US 65 northbound.
Route 39 is a two-lane highway in southwestern Missouri. Its northern terminus is at U.S. Route 54 between Collins and El Dorado Springs at the community of Cedar Springs; its southern terminus is at the Arkansas state line where it continues as Highway 221.
Route 376 is a short highway in Branson, Missouri. Its southern terminus is at Route 265, and its northern terminus is at Route 76.
Route 465 was a short highway in southern Missouri. It followed Ozark Mountain Highroad northwest of Branson. The southern terminus was at Route 76, while the northern terminus was at U.S. Route 65 north of Branson. There were plans to eventually reconnect the route to US 65.
Route 248 is a highway in southwestern Missouri. Its eastern terminus is at U.S. Route 65 in Branson. Its western terminus is at Route 76/Route 86/Route 112 in Cassville.
Route 176 is a highway in southwestern Missouri. The eastern terminus is at U.S. Route 160 north of Forsyth; its western terminus is at Route 248/Route 265/Route 413 in Galena.
Route 173 is a highway in southwestern Missouri. Its northern terminus is at Route 265/Route 413 in Elsey; its southern terminus is at Route 76 in Cape Fair.
Route 165 and County Road 165 (CR 165) form a loop around the west side of Branson, Missouri, in Taney and Stone counties. The highway's southern terminus is at U.S. Route 65 (US 65) south of Branson, in Hollister. Even though the county road designation belongs to Taney County, it briefly enters Stone County at Table Rock State Park. Upon re-entering Taney County, it crosses the Table Rock Lake Dam, along with Route 265, at Table Rock Lake. Its northern terminus is at US 65 along the Red Route in north Branson.
Route 110 is a short highway in Jefferson County. Its eastern terminus is at U.S. Route 67 about six miles (10 km) east of De Soto; its western terminus is at Route 21 a few miles north of De Soto. De Soto and Olympian Village are the only cities on the route.
Interstate 470 (I-470) is a 16.72-mile (26.91 km) loop of the Interstate Highway System that links southeast Kansas City to Independence via Lee's Summit in Jackson County, Missouri. The western terminus of the freeway is at the Grandview Triangle interchange with I-49, I-435, U.S. Route 50 (US 50), and US 71 while the northern terminus is a cloverleaf interchange with I-70. The freeway travels west to east through southern Kansas City, curving toward the north at the Lee's Summit Municipal Airport and becoming concurrent with Route 291 as the highway travels north toward Independence.
James River Freeway is a 14-mile-long (23 km) freeway located largely on the south side of Springfield, Missouri. Its western terminus is at Interstate 44 (I-44) north of Brookline and its eastern terminus is at U.S. Route 65 (US 65) in southeastern Springfield. It is named for the James River, which passes near the highway at the freeway's eastern terminus. A total of four highways are routed on the highway: Route 360, US 60, US 160, Route 13, and Business US 65.
U.S. Route 65 is a north–south U.S. highway that runs from Clayton, Louisiana to Albert Lea, Minnesota. In Missouri, the highway enters the state from Arkansas, just south of Branson. The highway exits the state into Iowa near South Lineville.
A total of eight special routes of U.S. Route 65 exist, divided between the U.S. states of Arkansas and Missouri. Currently, they are all business loops, although a spur route in Pine Bluff, Arkansas and bypass routes in Baton Rouge, Louisiana and Springfield, Missouri both existed in the past.
I-44 / I-44 BL / Route 43 in Joplin 
US 65 north of Ridgedale 
