U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel.
Route 43 is a highway in western Missouri. Its northern terminus is at U.S. Route 54 midway between Nevada and Deerfield. Its southern terminus is at the corner of Missouri, Arkansas, and Oklahoma where it continues down the Arkansas/Oklahoma state line as both Arkansas Highway 43 and Oklahoma State Highway 20.
Route 215 is a highway in southern Missouri. Its northern terminus is at Route 39 south of Stockton; its southern terminus is at U.S. Route 65 between Buffalo and Springfield. Except for a short section which overlaps Route 13, it is a two-lane highway its entire length. It was originally a set of supplemental routes. In the early 2000s, US 65 was realigned and the southern terminus was extended about one mile (1.6 km) east opposite the western terminus of Route O. The highway runs more east–west than north–south, but is marked as a north–south highway.
Route 13 is a highway in Missouri which runs almost the entire north–south length of the state. Its northern terminus is at U.S. Route 69/136 in Bethany. Its southern terminus is at the Arkansas state line in downtown Blue Eye, Missouri–Arkansas where it continues as Highway 21. It is one of the original state highways of Missouri.
Route 59 is a highway in southwest Missouri running from Interstate 44/Interstate 49/U.S. Route 71 at Fidelity to the Arkansas state line where it continues as Highway 59. It replaced a large section of U.S. Route 71 and Alternate US 71 in sections. The first section was designated in 1960 between Lanagan and the Arkansas state line when US 71 was moved down the former Route 88. In the 1990s, US 71 was moved and upgraded to interstate standards from Neosho to Lanagan and Route 59 was extended north to Neosho. When US 71 was moved east of Joplin in the late 1990s, Alternate US 71 was deleted, and Route 59 was extended north to replace that highway. The highway was numbered after Arkansas Highway 59.
Route 76 is a highway in the west half of southern Missouri running between U.S. Route 60 and U.S. Route 63 at Willow Springs and the Oklahoma state line near Tiff City where it continues as a county road. It bypasses Branson on the Ozark Mountain High Road and is the namesake of the Branson strip, 76 Country Blvd. The road runs for its entirety through the Missouri Ozarks, and is at times very hilly and curvy.
Route 7 is a state highway with its northern terminus at U.S. Route 24 in northeast Independence and its southern terminus at Interstate 44 southeast of Richland. The section between Harrisonville and Clinton provides an important link for traffic between Springfield and Kansas City.
Route 39 is a two-lane highway in southwestern Missouri. Its northern terminus is at U.S. Route 54 between Collins and El Dorado Springs at the community of Cedar Springs; its southern terminus is at the Arkansas state line where it continues as Highway 221.
Route 376 is a short highway in Branson, Missouri. Its southern terminus is at Route 265, and its northern terminus is at Route 76.
Route 291 is a state highway in the western part of the U.S. state of Missouri. Its southern terminus is at I-49/US 71 in Harrisonville; its northern terminus is at I-435 in Kansas City. The route was once designated as US 71 Bypass. Route 291 serves as a main arterial road and commercial strip in Liberty and Independence.
Route 248 is a highway in southwestern Missouri. Its eastern terminus is at U.S. Route 65 in Branson. Its western terminus is at Route 76/Route 86/Route 112 in Cassville.
Highway 43 is a designation for three north–south state highways in Arkansas. One segment of 27.1 miles (43.6 km) runs from Highway 264 in Siloam Springs north into Delaware County, Oklahoma along Oklahoma State Highway 20 (SH-20) to terminate at Missouri Route 43 (Route 43) at the Missouri/Oklahoma/Arkansas tri-point near Southwest City, Missouri. A second segment of 20.0 miles (32.2 km) runs northeast from Highway 21 at Boxley to Highway 7 in Harrison. The third segment runs 1.8 miles (2.9 km) north in Harrison from US Route 65 (US 65) to Highway 7.
Route 173 is a highway in southwestern Missouri. Its northern terminus is at Route 265/Route 413 in Elsey; its southern terminus is at Route 76 in Cape Fair.
Route 165 and County Road 165 (CR 165) form a loop around the west side of Branson, Missouri, in Taney and Stone counties. The highway's southern terminus is at U.S. Route 65 (US 65) south of Branson, in Hollister. Even though the county road designation belongs to Taney County, it briefly enters Stone County at Table Rock State Park. Upon re-entering Taney County, it crosses the Table Rock Lake Dam, along with Route 265, at Table Rock Lake. Its northern terminus is at US 65 along the Red Route in north Branson.
Arkansas Highway 25 is a northeast–southwest state highway in north central Arkansas. The route runs 85.66 miles (137.86 km) from US 64 in Conway to US 63/412 in Black Rock through Greers Ferry, Batesville, and the foothills of The Ozarks.
A total of ten special routes of U.S. Route 71 exist, and another ten previously existed.
U.S. Route 65 is a north–south U.S. highway that runs from Clayton, Louisiana to Albert Lea, Minnesota. In Missouri, the highway enters the state from Arkansas, just south of Branson. The highway exits the state into Iowa near South Lineville.
A total of eight special routes of U.S. Route 65 exist, divided between the U.S. states of Arkansas and Missouri. Currently, they are all business loops, although a spur route in Pine Bluff, Arkansas and bypass routes in Baton Rouge, Louisiana and Springfield, Missouri both existed in the past.
K-146 is a 15.564-mile-long (25.048 km) east–west state highway in eastern Kansas. K-146's western terminus is at U.S. Route 59 (US-59) north of Erie in Neosho County. The eastern terminus is at K-3 northwest of Girard in Crawford County. The main purpose of the route is to serve the small city of Walnut. The highway is two-lanes for its entire length, and no part of it is included in the National Highway System.
I-44 / I-44 BL / Route 43 in Joplin 
I-49 / I-49 BL / US 71 in Neosho 
US 60 / Route 59 near Neosho
US 65 north of Ridgedale 
