U.S. Route 412 is an east–west United States highway, first commissioned in 1982. U.S. 412 overlaps expressway-grade Cimarron Turnpike from Tulsa west to Interstate 35 and the Cherokee Turnpike from 5 miles (8.0 km) east of Chouteau, Oklahoma, to 8 miles (13 km) west of the Arkansas state line. It runs the entire length of the Oklahoma Panhandle and traverses the Missouri Bootheel. Despite its numbering it is not associated with U.S. Route 12.
U.S. Route 67 is a major north–south U.S. highway which extends for 1,560 miles (2,511 km) in the Central United States. The southern terminus of the route is at the United States-Mexico border in Presidio, Texas, where it continues south as Mexican Federal Highway 16 upon crossing the Rio Grande. The northern terminus is at U.S. Route 52 in Sabula, Iowa. US 67 crosses the Mississippi River twice along its routing. The first crossing is at West Alton, Missouri, where US 67 uses the Clark Bridge to reach Alton, Illinois. About 240 miles (390 km) to the north, US 67 crosses the river again at the Rock Island Centennial Bridge between Rock Island, Illinois, and Davenport, Iowa. Additionally, the route crosses the Missouri River via the Lewis Bridge a few miles southwest of the Clark Bridge.
U.S. Route 71 or U.S. Highway 71 is a major north–south United States highway that extends for over 1500 miles (2500 km) in the central United States. This original 1926 route has remained largely unchanged by encroaching Interstate highways. Currently, the highway's northern terminus is in International Falls, Minnesota at the Canada–US border, at the southern end of the Fort Frances-International Falls International Bridge to Fort Frances, Ontario. U.S. Route 53 also ends here. On the other side of the bridge, Trans-Canada Highway is an east–west route while Ontario Highway 71 is a north–south route. US 71's southern terminus is between Port Barre and Krotz Springs, Louisiana at an intersection with U.S. Route 190. For the entirety south of Kansas City, Missouri, US 71 runs parallel and concurrent with the existing and future Interstate 49. North of Kansas City, US 71 runs halfway between Interstate 29 and Interstate 35, which they split in the city at an interchange with Interstate 70.
U.S. Route 183 (US 183) is a north–south United States highway. The highway's northern terminus is in Presho, South Dakota, at an intersection with Interstate 90. Its southern terminus is in Refugio, Texas, at the southern intersection of U.S. Highway 77 and Alternate US 77.
U.S. Route 166 (US 166) is a 164-mile (264 km) east–west United States highway. This route and US 266 are the only two remaining spurs of historic U.S. Route 66, since US 666 was renumbered to US 491 in 2003.
U.S. Route 63 (US 63) is a 1,286-mile (2,070 km), north–south United States Highway primarily in the Midwestern and Southern United States. The southern terminus of the route is at Interstate 20 (I-20) in Ruston, Louisiana; the northern terminus is at US 2 eight miles (13 km) west of Ashland, Wisconsin.
Route 66 is a fourteen-mile (21 km) long road in southwest Missouri, USA, which had previously been U.S. Route 66 for its final six years. The highway begins at Interstate 44, passes through Duenweg, Duquesne, and Joplin, then crosses into Kansas becoming K-66.
Route 14 is a state highway traveling through the southern part of the U.S. state of Missouri. Its western terminus is at U.S. Route 60 (US 60) in Marionville, and its eastern terminus is at US 63 on the northern edge of West Plains. Route 14 is a two-lane highway for its entire length, however, there are plans to widen Route 14 in some spots.
Missouri Route 5 is the longest state highway in Missouri and the only Missouri state highway to traverse the entire state. It is part of a three state, 650 mile highway 5. To the north, it continues into Iowa as Iowa Highway 5 and to the south it enters Arkansas as Highway 5. With only a few exceptions, it is two-lane for its entire length. Business Route 5 serves Milan and Ava.
Route 215 is a highway in southern Missouri. Its northern terminus is at Route 39 south of Stockton; its southern terminus is at U.S. Route 65 between Buffalo and Springfield. Except for a short section which overlaps Route 13, it is a two-lane highway its entire length. It was originally a set of supplemental routes. In the early 2000s, US 65 was realigned and the southern terminus was extended about one mile (1.6 km) east opposite the western terminus of Route O. The highway runs more east–west than north–south, but is marked as a north–south highway.
Route 13 is a highway in Missouri which runs almost the entire north–south length of the state. Its northern terminus is at U.S. Route 69/136 in Bethany. Its southern terminus is at the Arkansas state line in downtown Blue Eye, Missouri–Arkansas where it continues as Highway 21. It is one of the original state highways of Missouri.
Route 37 is a highway in southwest Missouri. Its northern terminus is at U.S. Route 160 in Golden City ; its southern terminus is at the Arkansas state line where it continues as Highway 37, though it only runs very briefly before ending at U.S. Route 62 in Gateway, Arkansas.
Route 32 is a highway in Missouri. Its eastern terminus is at the Mississippi River near Ste. Genevieve; its western terminus is at U.S. Route 54 in El Dorado Springs. It is currently one of the longest highways in the state. Most of the highway east of Lebanon is hilly and curvy, passing through a large part of the Missouri Ozarks.
Arkansas Highway 23 is a north–south state highway in north Arkansas. The route runs 129.88 miles (209.02 km) from US 71 near Elm Park north to the Missouri state line through Ozark and Eureka Springs. Between AR 16 at Brashears and Interstate 40 north of Ozark, Highway 23 winds through the Ozark National Forest and is designated as the Pig Trail Scenic Byway due to its steep hills and hairpin turns. The route has a strong connection with the University of Arkansas Razorbacks, connecting fans in Central Arkansas with the Northwest Arkansas area.
Highway 21 is a north–south state highway in north central Arkansas. The route of 99.14 miles (159.55 km) runs from US Route 64 (US 64) in Clarksville north across US 62 to Missouri Route 13 at the Missouri state line The route is a two-lane highway with the exception of a brief concurrency with US 62, a four-lane highway, in Berryville.
North Carolina Highway 58 (NC 58) is a primary state highway in the U.S. state of North Carolina that traverses the state's Coastal Plain. The route links many of the Crystal Coast communities along its eastern segment. Its southern terminus is at the visitor center parking lot for Fort Macon State Park in Atlantic Beach and its northern terminus is at the intersection of US 401 and US 158 Business in Warrenton. The highway traverses nearly the entire length of the Bogue Banks and serves the major cities of Kinston, Snow Hill, and Wilson.
State Route 39 is a 118-mile-long (190 km) state highway that travels south-to-north through portions of Seminole, Miller, Early, Clay, Quitman, and Stewart counties in the southwestern part of the U.S. state of Georgia. The route proceeds north from its southern terminus along the shore of Lake Seminole in southern Seminole County to a point just southwest of Omaha, where it travels in an easterly direction until it meets its northern terminus, an intersection with US 27/SR 1 in a rural south of the unincorporated community of Louvale.
Highway 1 is a north–south state highway in east Arkansas. The route of 159.88 miles (257.30 km) runs from US Route 278 (US 278) in McGehee north to Supplemental Route BB at the Missouri state line. One of the original 1926 state highways, Highway 1 has remained very close to its original routing. The highway contains an overlap of approximately 50 miles (80 km) with U.S. Route 49.
State Route 62 (SR 62) is a 62.1-mile-long (99.9 km) state highway in the southwestern part of the U.S. state of Georgia. It connects Columbia, Alabama with Albany.
South Carolina Highway 4 (SC 4) is a primary 54.430-mile-long (87.597 km) state highway in the southern part of the U.S. state of South Carolina. The highway connects Aiken and Orangeburg, via Springfield and Neeses.
AR 221 at the Arkansas state line
US 54 in Cedar Springs 
