Monocarboxylate transporter 6

SLC16A5
Identifiers
Aliases	SLC16A5 , MCT5, MCT6, solute carrier family 16 member 5, Monocarboxylate transporter 6
External IDs	OMIM: 603879 MGI: 2443515 HomoloGene: 20985 GeneCards: SLC16A5
Gene location (Human)
Chr.	Chromosome 17 (human)
End	75,106,162 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	115,365,224 bp
RNA expression pattern
	Top expressed in
	bronchial epithelial cell; ; right uterine tube; ; pancreatic ductal cell; ; upper lobe of left lung; ; oocyte; ; duodenum; ; right lung; ; monocyte; ; blood; ; kidney;
	Top expressed in
	thymus; ; jejunum; ; duodenum; ; Epithelium of stomach; ; colon; ; left colon; ; kidney; ; ileum; ; medullary collecting duct; ; morula;
	More reference expression data
	n/a
Gene ontology
Molecular function	symporter activity ; monocarboxylic acid transmembrane transporter activity ;
Cellular component	integral component of membrane ; plasma membrane ; integral component of plasma membrane ; membrane ;
Biological process	monocarboxylic acid transport ; transmembrane transport ;
	Sources:Amigo / QuickGO
Orthologs
	9121
	217316
	ENSG00000170190
	ENSMUSG00000045775
	O15375
	G5E8K6
	NM_001271765 ; NM_004695 ; NM_001369668
	NM_001080934 ; NM_001359606 ; NM_001359608 ; NM_001359609
	NP_001258694 ; NP_004686 ; NP_001356597
	NP_001074403 ; NP_001346535 ; NP_001346537 ; NP_001346538
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 14, 2022

Monocarboxylate transporter 6 (MCT6) is a protein in humans that is encoded by the SLC16A5 gene.^[5]

This gene encodes a member of the monocarboxylate transporter family and the major facilitator superfamily. The encoded protein is localized to the cell membrane and acts as a proton-linked transporter of bumetanide. Transport by the encoded protein is inhibited by four loop diuretics, nateglinide, thiazides, probenecid, and glibenclamide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012].

Related Research Articles

Monocarboxylate transporter 5 is a protein that in humans is encoded by the SLC16A4 gene.

Monocarboxylate transporter 4 (MCT4) also known as solute carrier family 16 member 3 is a protein that in humans is encoded by the SLC16A3 gene.

Vesicular inhibitory amino acid transporter is a protein that in humans is encoded by the SLC32A1 gene.

Sodium-coupled monocarboxylate transporter 1 is a protein that in humans is encoded by the SLC5A8 gene.

Zinc transporter ZIP10, also known as solute carrier family 39 member 10, is a protein that in humans is encoded by the SLC39A10 gene. ZIP10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters, and have 14 members in the human genome: ZIP1, ZIP2, ZIP3, ZIP4, ZIP5, ZIP6, ZIP7, ZIP8, ZIP9, ZIP10, ZIP11, ZIP12, ZIP13 and ZIP14.

Mitochondrial glycine transporter is a protein that in humans is encoded by the SLC25A38 gene. SLC25A38 is involved in mitochondrial handling of glycine and is needed for the first step in heme synthesis. Mutations in this gene can lead to an autosomal recessive form of sideroblastic anemia.

Monocarboxylate transporter 10, also known as aromatic amino acid transporter 1 and T-type amino acid transporter 1 (TAT1) and solute carrier family 16 member 10 (SLC16A10), is a protein that in humans is encoded by the SLC16A10 gene. SLC16A10 is a member of the solute carrier family.

Monocarboxylate transporter 9 is a protein that in humans is encoded by the SLC16A9 gene.

Calcium-binding mitochondrial carrier protein SCaMC-1 is a protein that in humans is encoded by the SLC25A24 gene.

Solute carrier family 7, member 14 is a protein that in humans is encoded by the SLC7A14 gene.

Glucose-6-phosphate exchanger SLC37A2 is a protein that in humans is encoded by the SLC37A2 gene.

Monocarboxylate transporter 2 (MCT2) also known as solute carrier family 16 member 7 (SLC16A7) is a protein that in humans is encoded by the SLC16A7 gene. MCT2 is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate and beta-hydroxybutyrate. It also functions as high-affinity pyruvate transporter.

Monocarboxylate transporter 3 (MCT3) also known as solute carrier family 16 member 8 is a protein that in humans is encoded by the SLC16A8 gene. MCT is a proton-coupled monocarboxylate transporter. It catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. It also functions as high-affinity pyruvate transporter.

Sodium-dependent phosphate transport protein 2A, also known as Na⁺-P_i cotransporter 2a (NaPi-2a), is a protein in humans that is encoded by the SLC34A1 gene. This gene encodes a member of the type II sodium-phosphate cotransporter family.

Solute carrier family 17, member 6 is a protein that in humans is encoded by the SLC17A6 gene.

Solute carrier family 22 member 15 is a protein that in humans is encoded by the SLC22A15 gene.

Solute carrier family 17 member 9 is a protein that in humans is encoded by the SLC17A9 gene.

Solute carrier family 22 member 13 is a protein that in humans is encoded by the SLC22A13 gene.

Solute carrier family 38 member 5 is a protein that in humans is encoded by the SLC38A5 gene.

Solute carrier family 22 member 14 is a protein that in humans is encoded by the SLC22A14 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170190 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045775 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Solute carrier family 16, member 5 (monocarboxylic acid transporter 6)".

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170190 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000045775 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Solute carrier family 16, member 5 (monocarboxylic acid transporter 6)".

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