Morc family cw-type zinc finger 1

MORC1
Identifiers
Aliases	MORC1 , CT33, MORC, ZCW6, MORC family CW-type zinc finger 1
External IDs	OMIM: 603205 MGI: 1316740 HomoloGene: 7843 GeneCards: MORC1
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3q13.13 Start 108,958,248 bp [1] End 109,118,134 bp [1]
Gene location (Mouse) Chr. Chromosome 16 (mouse) [2] Band 16 B5|16 30.75 cM Start 48,251,600 bp [2] End 48,451,263 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle monocyte duodenum placenta anterior pituitary hippocampus proper substantia nigra spinal cord hypothalamus ovary Top expressed in secondary oocyte morula blastocyst spermatocyte spermatid Meckel's cartilage thymus testicle axial skeleton seminiferous tubule More reference expression data BioGPS n/a
Gene ontology Molecular function zinc ion binding metal ion binding Cellular component nucleus male germ cell nucleus Biological process multicellular organism development cell differentiation spermatogenesis negative regulation of transposition regulation of gene expression, epigenetic DNA methylation involved in gamete generation DNA hypermethylation negative regulation of DNA-templated transcription, initiation behavioral fear response negative regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27136 17450 Ensembl ENSG00000114487 ENSMUSG00000022652 UniProt Q86VD1 Q9WVL5 RefSeq (mRNA) NM_014429 NM_010816 RefSeq (protein) NP_055244 NP_034946 Location (UCSC) Chr 3: 108.96 – 109.12 Mb Chr 16: 48.25 – 48.45 Mb PubMed search [3] [4]
Wikidata
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MORC family CW-type zinc finger 1 is a protein that in humans is encoded by the MORC1 gene. ^[5]

Function

This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009].

References

1. GRCh38: Ensembl release 89: ENSG00000114487 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022652 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: MORC family CW-type zinc finger 1" . Retrieved 2018-07-12.

Further reading

• Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC   2896464 . PMID   20379614.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.