N-acetyltransferase 2

Last updated
NAT2
Protein NAT2 PDB 2pfr.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NAT2 , AAC2, NAT-2, PNAT, N-acetyltransferase 2, N-acetyltransferase 2 (arylamine N-acetyltransferase)
External IDs OMIM: 612182 MGI: 97279 HomoloGene: 115468 GeneCards: NAT2
Orthologs
SpeciesHumanMouse
Entrez

10

17960

Ensembl

ENSG00000156006

ENSMUSG00000025588

UniProt

P11245

P50294

RefSeq (mRNA)

NM_000015

NM_008673

RefSeq (protein)

NP_000006

NP_032699

Location (UCSC) Chr 8: 18.39 – 18.4 Mb Chr 8: 67.93 – 67.94 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

N-acetyltransferase 2 (arylamine N-acetyltransferase), also known as NAT2, is an enzyme which in humans is encoded by the NAT2 gene. [5]

Contents

Function

This gene encodes a type of N-acetyltransferase. The NAT2 isozyme functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in NAT2 are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near NAT2. [6]

Phenotype prediction

The NAT2 acetylator phenotype can be inferred from NAT2 genotype (a combination of SNPs observed in a given individual). [7] [8] [9] [10]

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Edith Sim is a British researcher who is an emeritus professor at Kingston University and the University of Oxford. She was awarded the 2012 British Pharmacological Society John Vane Medal and a lifetime achievement award in 2015 from the Arylamine N-acetyltransferases Workshop Group.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000156006 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000025588 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV, Sim E, Suzuki T, Yamazoe Y (February 1995). "Nomenclature for N-acetyltransferases". Pharmacogenetics. 5 (1): 1–17. doi:10.1097/00008571-199502000-00001. PMID   7773298.
  6. ↑ "Entrez Gene: NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase)".
  7. ↑ "NAT2PRED: a computational predictor of the human N-AcetylTransferase-2 (NAT2) acetylator phenotype". State University of New York – Albany. Archived from the original on 2009-05-22. Retrieved 2009-04-30.
  8. ↑ Kuznetsov IB, McDuffie M, Moslehi R (May 2009). "A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype". Bioinformatics. 25 (9): 1185–6. doi:10.1093/bioinformatics/btp121. PMC   2672629 . PMID   19261719.
  9. ↑ Agúndez JA (2008). "Polymorphisms of human N-acetyltransferases and cancer risk". Curr. Drug Metab. 9 (6): 520–31. doi:10.2174/138920008784892083. PMID   18680472.
  10. ↑ Agúndez JA (2008). "N-acetyltransferases: lessons learned from eighty years of research". Curr. Drug Metab. 9 (6): 463–4. doi:10.2174/138920008784892146. PMID   18680465.

Further reading


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