| N6AMT1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | N6AMT1 , C21orf127, HEMK2, MTQ2, N6AMT, m.HsaHemK2P, PRED28, N-6 adenine-specific DNA methyltransferase 1 (putative), N-6 adenine-specific DNA methyltransferase 1, PrmC, KMT9 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 614553; MGI: 1915018; HomoloGene: 5637; GeneCards: N6AMT1; OMA:N6AMT1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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N-6 adenine-specific DNA methyltransferase 1 is a protein that in humans is encoded by the N6AMT1 gene. [5]
The N6AMT1 gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]. N6AMT1 functions as a protein glutamine methyltransferase and is essential for mouse development (Liu et al., Mol. Cell. Biol. 2010).
DNA (cytosine-5)-methyltransferase 1(Dnmt1) is an enzyme that catalyzes the transfer of methyl groups to specific CpG sites in DNA, a process called DNA methylation. In humans, it is encoded by the DNMT1 gene. Dnmt1 forms part of the family of DNA methyltransferase enzymes, which consists primarily of DNMT1, DNMT3A, and DNMT3B.
DNA (cytosine-5)-methyltransferase 3 beta, is an enzyme that in humans in encoded by the DNMT3B gene. Mutation in this gene are associated with immunodeficiency, centromere instability and facial anomalies syndrome.
CARM1, also known as PRMT4, is an enzyme encoded by the CARM1 gene found in human beings, as well as many other mammals. It has a polypeptide (L) chain type that is 348 residues long, and is made up of alpha helices and beta sheets. Its main function includes catalyzing the transfer of a methyl group from S-Adenosyl methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-Adenosyl-L-homocysteine. CARM1 is a secondary coactivator through its association with p160 family of coactivators. It is responsible for moving cells toward the inner cell mass in developing blastocysts.
Protein arginine N-methyltransferase 1 is an enzyme that in humans is encoded by the PRMT1 gene. The HRMT1L2 gene encodes a protein arginine methyltransferase that functions as a histone methyltransferase specific for histone H4.
DNA (cytosine-5)-methyltransferase 3A (DNMT3A) is an enzyme that catalyzes the transfer of methyl groups to specific CpG structures in DNA, a process called DNA methylation. The enzyme is encoded in humans by the DNMT3A gene.
Estrogen sulfotransferase is an enzyme that in humans is encoded by the SULT1E1 gene.
Sulfotransferase 1A2 is an enzyme that in humans is encoded by the SULT1A2 gene.
Lysine N-methyltransferase 2C (KMT2C) also known as myeloid/lymphoid or mixed-lineage leukemia protein 3 (MLL3) is an enzyme that in humans is encoded by the KMT2C gene.
Glutathione S-transferase omega-1 is an enzyme that in humans is encoded by the GSTO1 gene.
Nicotinamide N-methyltransferase (NNMT) is an enzyme that in humans is encoded by the NNMT gene. NNMT catalyzes the methylation of nicotinamide and similar compounds using the methyl donor S-adenosyl methionine (SAM-e) to produce S-adenosyl-L-homocysteine (SAH) and 1-methylnicotinamide.
Histone-lysine N-methyltransferase SETD7 is an enzyme that in humans is encoded by the SETD7 gene.
tRNA (cytosine-5-)-methyltransferase is an enzyme that in humans is encoded by the TRDMT1 gene.
SET and MYND (myeloid-Nervy-DEAF-1) domain-containing protein 3 is a protein that in humans is encoded by the SMYD3 gene.
Histone-lysine N-methyltransferase KMT5B is an enzyme that in humans is encoded by the KMT5B gene. The enzyme along with WHSC1 is responsible for dimethylation of lysine 20 on histone H4 in mouse and humans.
Protein arginine N-methyltransferase 6 is an enzyme that in humans is encoded by the PRMT6 gene.
Leucine carboxyl methyltransferase 2 is an enzyme that in humans is encoded by the LCMT2 gene.
DOT1-like, histone H3K79 methyltransferase, also known as DOT1L, is a protein found in humans, as well as other eukaryotes.
Arsenite methyltransferase is an enzyme that in humans is encoded by the AS3MT gene.
Malate dehydrogenase, cytoplasmic also known as malate dehydrogenase 1 is an enzyme that in humans is encoded by the MDH1 gene.
Methyltransferase like 14 is a protein that in humans is encoded by the METTL14 gene.
Peng Liu, Song Nie, Bing Li, Zhong-Qiang Yang, Zhi-Mei Xu, Jian Fei, Chyuansheng Lin, Rong Zeng, and Guo-Liang Xu. Deficiency in a Glutamine-Specific Methyltransferase for Release Factor Causes Mouse Embryonic Lethality. MOLECULAR AND CELLULAR BIOLOGY, Sept. 2010, p. 4245–4253 Vol. 30, No. 17 0270-7306/10/
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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