NAB1

NAB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YUF
Identifiers
Aliases	NAB1 , NGFI-A binding protein 1
External IDs	OMIM: 600800; MGI: 107564; HomoloGene: 4352; GeneCards: NAB1; OMA:NAB1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q32.2 Start 190,646,746 bp [1] End 190,692,766 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 C1.1|1 26.99 cM Start 52,496,453 bp [2] End 52,539,838 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence skin of hip skin of thigh Achilles tendon endothelial cell Epithelium of choroid plexus ventricular zone epithelium of colon optic nerve tendon of biceps brachii Top expressed in carotid body saccule molar otic placode conjunctival fornix calvaria ascending aorta skin of external ear iris seminal vesicula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding transcription coregulator activity Cellular component nucleus Biological process Schwann cell differentiation myelination endochondral ossification regulation of epidermis development transcription, DNA-templated negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4664 17936 Ensembl ENSG00000138386 ENSMUSG00000002881 UniProt Q13506 Q61122 RefSeq (mRNA) NM_005966 NM_001321312 NM_001321313 NM_001321314 NM_001321315 NM_008667 RefSeq (protein) NP_001308241 NP_001308242 NP_001308243 NP_001308244 NP_005957 NP_032693 Location (UCSC) Chr 2: 190.65 – 190.69 Mb Chr 1: 52.5 – 52.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NGFI-A-binding protein 1 is a protein that in humans is encoded by the NAB1 gene. ^{[5] [6] [7] [8]}

Interactions

NAB1 has been shown to interact with Zif268. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000138386 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002881 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Russo MW, Sevetson BR, Milbrandt J (Aug 1995). "Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription". Proc Natl Acad Sci U S A. 92 (15): 6873–7. Bibcode:1995PNAS...92.6873R. doi: 10.1073/pnas.92.15.6873 . PMC   41432 . PMID   7624335.
6. Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol. 16 (7): 3545–53. doi:10.1128/MCB.16.7.3545. PMC   231349 . PMID   8668170.
7. Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J (Jan 1998). "Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain". Mol Cell Biol. 18 (1): 512–24. doi:10.1128/MCB.18.1.512. PMC   115883 . PMID   9418898.
8. "Entrez Gene: NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Thiel G, Kaufmann K, Magin A, et al. (2000). "The human transcriptional repressor protein NAB1: expression and biological activity". Biochim. Biophys. Acta. 1493 (3): 289–301. doi:10.1016/s0167-4781(00)00207-4. PMID   11018254.
• Qiu FH, Devchand PR, Wada K, Serhan CN (2002). "Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils". FASEB J. 15 (14): 2736–8. doi: 10.1096/fj.01-0576fje . PMID   11687510. S2CID   23166941.
• Venken K, Di Maria E, Bellone E, et al. (2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies". Neurogenetics. 4 (1): 37–41. doi:10.1007/s10048-001-0124-2. PMID   12030330. S2CID   1928229.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.