NAB1

NAB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2YUF
Identifiers
Aliases	NAB1 , NGFI-A binding protein 1
External IDs	OMIM: 600800 MGI: 107564 HomoloGene: 4352 GeneCards: NAB1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	190,692,766 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	52,539,838 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Achilles tendon; ; endothelial cell; ; optic nerve; ; gums; ; right coronary artery; ; parietal pleura; ; cerebellar vermis; ; germinal epithelium; ; bronchial epithelial cell;
	Top expressed in
	carotid body; ; saccule; ; molar; ; otic placode; ; conjunctival fornix; ; calvaria; ; ascending aorta; ; iris; ; seminal vesicula; ; sciatic nerve;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transcription factor binding ; transcription coregulator activity ;
Cellular component	nucleus ;
Biological process	Schwann cell differentiation ; myelination ; endochondral ossification ; regulation of epidermis development ; transcription, DNA-templated ; negative regulation of transcription, DNA-templated ; regulation of transcription, DNA-templated ;
	Sources:Amigo / QuickGO
Orthologs
	4664
	17936
	ENSG00000138386
	ENSMUSG00000002881
	Q13506
	Q61122
	NM_005966 ; NM_001321312 ; NM_001321313 ; NM_001321314 ; NM_001321315 Contents Interactions ; References ; Further reading ;
	NM_008667
	NP_001308241 ; NP_001308242 ; NP_001308243 ; NP_001308244 ; NP_005957
	NP_032693
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 28, 2024

NGFI-A-binding protein 1 is a protein that in humans is encoded by the NAB1 gene.^[5]^[6]^[7]^[8]

Interactions

NAB1 has been shown to interact with Zif268.^[5]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138386 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002881 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Russo MW, Sevetson BR, Milbrandt J (Aug 1995). "Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription". Proc Natl Acad Sci U S A. 92 (15): 6873–7. Bibcode:1995PNAS...92.6873R. doi: 10.1073/pnas.92.15.6873 . PMC 41432 . PMID 7624335.
↑ Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol. 16 (7): 3545–53. doi:10.1128/MCB.16.7.3545. PMC 231349 . PMID 8668170.
↑ Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J (Jan 1998). "Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain". Mol Cell Biol. 18 (1): 512–24. doi:10.1128/MCB.18.1.512. PMC 115883 . PMID 9418898.
↑ "Entrez Gene: NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)".

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Thiel G, Kaufmann K, Magin A, et al. (2000). "The human transcriptional repressor protein NAB1: expression and biological activity". Biochim. Biophys. Acta. 1493 (3): 289–301. doi:10.1016/s0167-4781(00)00207-4. PMID 11018254.
Qiu FH, Devchand PR, Wada K, Serhan CN (2002). "Aspirin-triggered lipoxin A4 and lipoxin A4 up-regulate transcriptional corepressor NAB1 in human neutrophils". FASEB J. 15 (14): 2736–8. doi: 10.1096/fj.01-0576fje . PMID 11687510. S2CID 23166941.
Venken K, Di Maria E, Bellone E, et al. (2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies". Neurogenetics. 4 (1): 37–41. doi:10.1007/s10048-001-0124-2. PMID 12030330. S2CID 1928229.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID 15815621.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID 17081983. S2CID 7827573.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138386 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002881 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7624335-5] 1 2 Russo MW, Sevetson BR, Milbrandt J (Aug 1995). "Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription". Proc Natl Acad Sci U S A. 92 (15): 6873–7. Bibcode:1995PNAS...92.6873R. doi: 10.1073/pnas.92.15.6873 . PMC 41432 . PMID 7624335.

[pmid8668170-6] Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol. 16 (7): 3545–53. doi:10.1128/MCB.16.7.3545. PMC 231349 . PMID 8668170.

[pmid9418898-7] Swirnoff AH, Apel ED, Svaren J, Sevetson BR, Zimonjic DB, Popescu NC, Milbrandt J (Jan 1998). "Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain". Mol Cell Biol. 18 (1): 512–24. doi:10.1128/MCB.18.1.512. PMC 115883 . PMID 9418898.

[entrez-8] "Entrez Gene: NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1)".

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NAB1

Contents

Interactions

Related Research Articles

References

Further reading