NAB2

NAB2
Identifiers
Aliases	NAB2 , MADER, NGFI-A binding protein 2
External IDs	OMIM: 602381; MGI: 107563; HomoloGene: 4353; GeneCards: NAB2; OMA:NAB2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q13.3 Start 57,089,043 bp [1] End 57,095,476 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 D3|10 74.6 cM Start 127,496,787 bp [2] End 127,504,437 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum left ovary right ovary popliteal artery canal of the cervix tibial arteries left uterine tube Descending thoracic aorta body of uterus anterior pituitary Top expressed in cerebellar vermis lobe of cerebellum lip calvaria external carotid artery internal carotid artery Gonadal ridge superior frontal gyrus olfactory tubercle dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transcription factor binding protein binding transcription corepressor activity identical protein binding transcription coregulator activity Cellular component nucleus Biological process Schwann cell differentiation myelination negative regulation of transcription by RNA polymerase III cell population proliferation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated endochondral ossification regulation of epidermis development transcription, DNA-templated nervous system development positive regulation of tau-protein kinase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4665 17937 Ensembl ENSG00000166886 ENSMUSG00000025402 UniProt Q15742 Q61127 RefSeq (mRNA) NM_005967 NM_001330305 NM_001122895 NM_008668 RefSeq (protein) NP_001317234 NP_005958 NP_001116367 NP_032694 Location (UCSC) Chr 12: 57.09 – 57.1 Mb Chr 10: 127.5 – 127.5 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NGFI-A-binding protein 2 also known as EGR-1-binding protein 2 or melanoma-associated delayed early response protein (MADER) is a protein that in humans is encoded by the NAB2 gene. ^{[5] [6] [7]}

Function

This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress or activate transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. ^[7]

Pathology

Recurrent somatic fusions of the two genes, NGFI-A–binding protein 2 (NAB2) and STAT6, located at chromosomal region 12q13, have been identified in solitary fibrous tumors. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000166886 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000025402 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Svaren J, Sevetson BR, Apel ED, Zimonjic DB, Popescu NC, Milbrandt J (Aug 1996). "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli". Mol Cell Biol. 16 (7): 3545–53. doi:10.1128/MCB.16.7.3545. PMC   231349 . PMID   8668170.
6. Kirsch KH, Korradi Y, Johnson JP (Jul 1996). "Mader: a novel nuclear protein over expressed in human melanomas". Oncogene. 12 (5): 963–71. PMID   8649813.
7. "Entrez Gene: NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2)".
8. Kabbinavar, F. F.; Hambleton, J; Mass, R. D.; Hurwitz, H. I.; Bergsland, E; Sarkar, S (2005). "Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer". Journal of Clinical Oncology. 23 (16): 3706–12. doi: 10.1200/JCO.2005.00.232 . PMID   15867200.

Further reading

• Svaren J, Apel ED, Simburger KS, et al. (1997). "The Nab2 and Stat6 genes share a common transcription termination region". Genomics. 41 (1): 33–9. doi:10.1006/geno.1997.4609. PMID   9126479.
• Qu Z, Wolfraim LA, Svaren J, et al. (1998). "The transcriptional corepressor NAB2 inhibits NGF-induced differentiation of PC12 cells". J. Cell Biol. 142 (4): 1075–82. doi:10.1083/jcb.142.4.1075. PMC   2132876 . PMID   9722618.
• Svaren J, Sevetson BR, Golda T, et al. (1998). "Novel mutants of NAB corepressors enhance activation by Egr transactivators". EMBO J. 17 (20): 6010–9. doi:10.1093/emboj/17.20.6010. PMC   1170927 . PMID   9774344.
• Abdulkadir SA, Qu Z, Garabedian E, et al. (2001). "Impaired prostate tumorigenesis in Egr1-deficient mice". Nat. Med. 7 (1): 101–7. doi:10.1038/83231. PMID   11135623. S2CID   7191051.
• Abdulkadir SA, Carbone JM, Naughton CK, et al. (2001). "Frequent and early loss of the EGR1 corepressor NAB2 in human prostate carcinoma". Hum. Pathol. 32 (9): 935–9. doi:10.1053/hupa.2001.27102. PMID   11567222.
• Venken K, Di Maria E, Bellone E, et al. (2003). "Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies". Neurogenetics. 4 (1): 37–41. doi:10.1007/s10048-001-0124-2. PMID   12030330. S2CID   1928229.
• Lucerna M, Mechtcheriakova D, Kadl A, et al. (2003). "NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells". J. Biol. Chem. 278 (13): 11433–40. doi: 10.1074/jbc.M204937200 . PMID   12427750.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kumbrink J, Gerlinger M, Johnson JP (2005). "Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop". J. Biol. Chem. 280 (52): 42785–93. doi: 10.1074/jbc.M511079200 . PMID   16260776.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Srinivasan R, Mager GM, Ward RM, et al. (2006). "NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex". J. Biol. Chem. 281 (22): 15129–37. doi: 10.1074/jbc.M600775200 . PMID   16574654.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.