NAP1L4

NAP1L4
Identifiers
Aliases	NAP1L4 , NAP1L4b, NAP2, NAP2L, hNAP2, nucleosome assembly protein 1 like 4
External IDs	OMIM: 601651 MGI: 1316687 HomoloGene: 133933 GeneCards: NAP1L4
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11p15.4 Start 2,944,431 bp [1] End 2,992,377 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 F5|7 88.24 cM Start 143,513,579 bp [2] End 143,549,106 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Achilles tendon bone marrow cells sural nerve gastrocnemius muscle minor salivary gland anterior pituitary appendix Brodmann area 9 rectum Top expressed in saccule ectoderm otic placode lens medullary collecting duct superior cervical ganglion primitive streak renal corpuscle spermatocyte ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding protein binding RNA binding nucleosome binding Cellular component nucleus cytoplasm Biological process nucleosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4676 17955 Ensembl ENSG00000205531 ENSG00000273562 ENSMUSG00000059119 UniProt Q99733 Q78ZA7 RefSeq (mRNA) NM_005969 NM_001285489 NM_001285490 NM_008672 RefSeq (protein) NP_005960 NP_001356304 NP_001356305 NP_001356306 NP_001356307 NP_001356308 NP_001356309 NP_001356310 NP_001356311 NP_001356312 NP_001356313 NP_001356314 NP_001356315 NP_001356317 NP_005960.1 NP_001272418 NP_001272419 NP_032698 Location (UCSC) Chr 11: 2.94 – 2.99 Mb Chr 7: 143.51 – 143.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleosome assembly protein 1-like 4 is a protein that in humans is encoded by the NAP1L4 gene. ^{[5] [6]}

This gene encodes a member of the nucleosome assembly protein (NAP) family which can interact with both core and linker histones. It can shuttle between the cytoplasm and nucleus, suggesting a role as a histone chaperone. This gene is one of several located near the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. ^[6]

References

1. ENSG00000273562 GRCh38: Ensembl release 89: ENSG00000205531, ENSG00000273562 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059119 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hu RJ, Lee MP, Johnson LA, Feinberg AP (Mar 1997). "A novel human homologue of yeast nucleosome assembly protein, 65 kb centromeric to the p57KIP2 gene, is biallelically expressed in fetal and adult tissues". Hum Mol Genet. 5 (11): 1743–8. doi: 10.1093/hmg/5.11.1743 . PMID   8923002.
6. "Entrez Gene: NAP1L4 nucleosome assembly protein 1-like 4".

Further reading

• Rodriguez P, Munroe D, Prawitt D, et al. (1997). "Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone". Genomics. 44 (3): 253–65. doi:10.1006/geno.1997.4868. PMID   9325046.
• Rodriguez P, Pelletier J, Price GB, Zannis-Hadjopoulos M (2000). "NAP-2: histone chaperone function and phosphorylation state through the cell cycle". J. Mol. Biol. 298 (2): 225–38. doi:10.1006/jmbi.2000.3674. PMID   10764593.
• Shikama N, Chan HM, Krstic-Demonacos M, et al. (2000). "Functional interaction between nucleosome assembly proteins and p300/CREB-binding protein family coactivators". Mol. Cell. Biol. 20 (23): 8933–43. doi:10.1128/MCB.20.23.8933-8943.2000. PMC   86548 . PMID   11073993.
• Cicala C, Arthos J, Selig SM, et al. (2002). "HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9380–5. Bibcode:2002PNAS...99.9380C. doi: 10.1073/pnas.142287999 . PMC   123149 . PMID   12089333.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Rodriguez P, Ruiz MT, Price GB, Zannis-Hadjopoulos M (2005). "NAP-2 is part of multi-protein complexes in HeLa cells". J. Cell. Biochem. 93 (2): 398–408. doi:10.1002/jcb.20163. PMID   15368365. S2CID   12368640.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.