NAV1

NAV1
Identifiers
Aliases	NAV1 , POMFIL3, STEERIN1, UNC53H1, neuron navigator 1
External IDs	OMIM: 611628 MGI: 2183683 HomoloGene: 10719 GeneCards: NAV1
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 201,622,885 bp [1] End 201,826,969 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 135,362,318 bp [2] End 135,615,843 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell external globus pallidus saphenous vein Brodmann area 23 middle temporal gyrus inferior ganglion of vagus nerve pericardium synovial joint medulla oblongata ventral tegmental area Top expressed in internal carotid artery external carotid artery ventromedial nucleus vas deferens subiculum ganglionic eminence otolith organ utricle olfactory bulb substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm microtubule cytoskeleton microtubule cytoskeleton axon initial segment Biological process multicellular organism development cell differentiation neuron migration microtubule bundle formation nervous system development neurogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89796 215690 Ensembl ENSG00000134369 ENSMUSG00000009418 UniProt Q8NEY1 Q8CH77 RefSeq (mRNA) NM_001167738 NM_020443 NM_173437 RefSeq (protein) NP_001161210 NP_065176 NP_775613 Location (UCSC) Chr 1: 201.62 – 201.83 Mb Chr 1: 135.36 – 135.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuron navigator 1 is a protein that in humans is encoded by the NAV1 gene. ^{[5] [6] [7]}

This gene belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities. This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. The exact function of this gene is not known. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000134369 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009418 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maes T, Barcelo A, Buesa C (Jun 2002). "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans". Genomics. 80 (1): 21–30. doi:10.1006/geno.2002.6799. PMID   12079279.
6. Coy JF, Wiemann S, Bechmann I, Bachner D, Nitsch R, Kretz O, Christiansen H, Poustka A (Jun 2002). "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms". Gene. 290 (1–2): 73–94. doi:10.1016/S0378-1119(02)00567-X. PMID   12062803.
7. "Entrez Gene: NAV1 neuron navigator 1".

Further reading

• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Peeters PJ, Baker A, Goris I, et al. (2004). "Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53". Brain Res. Dev. Brain Res. 150 (2): 89–101. doi:10.1016/j.devbrainres.2004.03.004. PMID   15158073.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Okazaki N, Kikuno R, Ohara R, et al. (2003). "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries". DNA Res. 10 (1): 35–48. doi: 10.1093/dnares/10.1.35 . PMID   12693553.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nakayama M, Kikuno R, Ohara O (2003). "Protein–Protein Interactions Between Large Proteins: Two-Hybrid Screening Using a Functionally Classified Library Composed of Long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC   187542 . PMID   12421765.
• Nagase T, Ishikawa K, Kikuno R, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID   10574462.
• Hirosawa M, Nagase T, Ishikawa K, et al. (2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID   10574461.