NCDN | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | NCDN , neurochondrin, NEDIES | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 608458 MGI: 1347351 HomoloGene: 8064 GeneCards: NCDN | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Neurochondrin (also known as its murine homologue, Norbin) is a protein that in humans is encoded by the NCDN gene. [5] [6]
This gene encodes a leucine-rich cytoplasmic protein, which is highly similar to a mouse protein norbin that negatively regulates Ca/calmodulin-dependent protein kinase II phosphorylation and may be essential for spatial learning processes. Several alternatively spliced transcript variants of this gene have been described. [6]
Norbin can modulate signaling activity and expression of metabotropic glutamate receptor 5; modulating mice with targeted deletion of NCDN in the brain have phenotypic traits usually found in the rodent models of schizophrenia, including disruptions in prepulse inhibition. [7] Furthermore, norbin protein expression is altered in the schizophrenia brain. [8] Norbin also plays a role in regulating antimicrobial responses in neutrophils. [9]
Neurochondrin proteins induce hydroxyapatite resorptive activity in bone marrow cells resistant to bafilomycin A1, an inhibitor of macrophage- and osteoclast-mediated resorption. Expression of the gene is localised to chondrocyte, osteoblast, and osteocyte in the bone and to the hippocampus and Purkinje cell layer of cerebellum in the brain. [10]
Steroid sulfatase (STS), or steryl-sulfatase, formerly known as arylsulfatase C, is a sulfatase enzyme involved in the metabolism of steroids. It is encoded by the STS gene.
The germ cell nuclear factor (GCNF), also known as RTR or NR6A1, is a protein that in humans is encoded by the NR6A1 gene. GCNF is a member of the nuclear receptor family of intracellular transcription factors.
Calmodulin 3 is a protein that in humans is encoded by the CALM3 gene.
DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.
Probable G-protein coupled receptor 26 is a protein that in humans is encoded by the GPR26 gene. GPR26 expression is found to peak perinatally, when the visual system is first challenged, and contains a 53 kb LD-block enriched for association with introgressed Neanderthal-derived SNPs. Additionally, it is known to form oligomeric structures with the 5-HT1a receptor.
Trace amine-associated receptor 2 (TAAR2), formerly known as G protein-coupled receptor 58 (GPR58), is a protein that in humans is encoded by the TAAR2 gene. TAAR2 is coexpressed with Gα proteins; however, as of February 2017, its signal transduction mechanisms have not been determined.
Putative trace amine-associated receptor 3 (TAAR3) is a human pseudogene with the gene symbol TAAR3P. In other species such as mice, TAAR3 is a functional protein-coding gene that encodes a trace amine-associated receptor protein.
Putative P2Y purinoceptor 10 is a protein that, in humans, is encoded by the P2RY10 gene.
P2Y purinoceptor 8 is a protein that in humans is encoded by the P2RY8 gene.
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.
Chromosome-associated kinesin KIF4A is a protein that in humans is encoded by the KIF4A gene.
Fatty acid binding protein 7, brain, is a human gene.
Dipeptidase 1 (DPEP1), or renal dipeptidase, is a membrane-bound glycoprotein responsible for hydrolyzing dipeptides. It is found in the microsomal fraction of the procine kidney cortex. It exists as a disulfide-linked homodimer that is glygosylphosphatidylinositol (GPI)-anchored to the renal brush border of the kidney. The active site on each homodimer is made up of a barrel subunit with binuclear zinc ions that are bridged by the Gly125 side-chain located at the bottom of the barrel.
40S ribosomal protein S29 is a protein that in humans is encoded by the RPS29 gene.
Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.
Ribonuclease 4 is an enzyme that in humans is encoded by the RNASE4 gene.
Pleckstrin homology-like domain family B member 1 is a protein that in humans is encoded by the PHLDB1 gene.
SPARC-related modular calcium-binding protein 2 is a protein that in humans is encoded by the SMOC2 gene.
3-Ketoacyl-CoA thiolase, mitochondrial also known as acetyl-Coenzyme A acyltransferase 2 is an enzyme that in humans is encoded by the ACAA2 gene.
Heat shock protein beta-3 (HspB3) also known as heat shock 27kDa protein 3 is a protein that in humans is encoded by the HSPB3 gene.