NDC1

NDC1
Identifiers
Aliases	NDC1 , NET3, TMEM48, NDC1 transmembrane nucleoporin
External IDs	OMIM: 610115; MGI: 1920037; HomoloGene: 41224; GeneCards: NDC1; OMA:NDC1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p32.3 Start 53,765,478 bp [1] End 53,838,463 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 C7 Start 107,224,981 bp [2] End 107,273,543 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte gonad ventricular zone tibia gingival epithelium epithelium of nasopharynx mucosa of colon mucosa of sigmoid colon germinal epithelium testicle Top expressed in tail of embryo genital tubercle primitive streak cumulus cell spermatocyte epiblast maxillary prominence condyle yolk sac medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of nuclear pore Cellular component cytoplasm integral component of membrane nuclear membrane nuclear envelope membrane plasma membrane nuclear pore actin cytoskeleton nucleus spindle pole body nuclear pore transmembrane ring host cell Biological process mRNA transport nuclear pore complex assembly viral transcription protein sumoylation mitotic nuclear membrane disassembly homologous chromosome pairing at meiosis spermatogenesis protein transport regulation of cellular response to heat viral process mRNA export from nucleus intracellular transport of virus tRNA export from nucleus spindle pole body duplication regulation of gene silencing by miRNA regulation of glycolytic process transport nuclear pore organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55706 72787 Ensembl ENSG00000058804 ENSMUSG00000028614 UniProt Q9BTX1 Q8VCB1 RefSeq (mRNA) NM_001168551 NM_018087 NM_028355 RefSeq (protein) NP_001162023 NP_060557 NP_082631 Location (UCSC) Chr 1: 53.77 – 53.84 Mb Chr 4: 107.22 – 107.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoporin NDC1 is a protein that in humans is encoded by the TMEM48 gene. ^{[5] [6] [7]} It anchors aladin to the nuclear pore complex. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000058804 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028614 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lau CK, Delmar VA, Forbes DJ (Aug 2006). "Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue". Anat Rec A. 288 (7): 681–94. doi:10.1002/ar.a.20335. PMC   3049984 . PMID   16779818.
6. Schirmer EC, Florens L, Guan T, Yates JR 3rd, Gerace L (Sep 2003). "Nuclear membrane proteins with potential disease links found by subtractive proteomics". Science. 301 (5638): 1380–2. Bibcode:2003Sci...301.1380S. doi:10.1126/science.1088176. PMID   12958361. S2CID   23832536.
7. "Entrez Gene: TMEM48 transmembrane protein 48".
8. Kind, Barbara; Koehler, Katrin; Lorenz, Mike; Huebner, Angela (December 2009). "The nuclear pore complex protein ALADIN is anchored via NDC1 but not via POM121 and GP210 in the nuclear envelope". Biochemical and Biophysical Research Communications. 390 (2): 205–210. doi:10.1016/j.bbrc.2009.09.080. PMID   19782045.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Mansfeld J, Güttinger S, Hawryluk-Gara LA, et al. (2006). "The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells". Mol. Cell. 22 (1): 93–103. doi: 10.1016/j.molcel.2006.02.015 . PMID   16600873.
• Stavru F, Hülsmann BB, Spang A, et al. (2006). "NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes" (PDF). J. Cell Biol. 173 (4): 509–19. doi:10.1083/jcb.200601001. PMC   2063861 . PMID   16702233.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.