NDFIP2

NDFIP2
Identifiers
Aliases	NDFIP2 , N4WBP5A, Nedd4 family interacting protein 2
External IDs	OMIM: 610041 MGI: 1923523 HomoloGene: 12636 GeneCards: NDFIP2
Gene location (Human)
Chr.	Chromosome 13 (human)
End	79,556,077 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	105,546,732 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; sperm; ; pancreatic epithelial cell; ; Brodmann area 46; ; palpebral conjunctiva; ; jejunal mucosa; ; pons; ; endothelial cell; ; germinal epithelium; ; postcentral gyrus;
	Top expressed in
	habenula; ; medial vestibular nucleus; ; olfactory tubercle; ; submandibular gland; ; ventral tegmental area; ; pontine nuclei; ; lateral geniculate nucleus; ; left colon; ; globus pallidus; ; barrel cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity ; protein binding ; WW domain binding ;
Cellular component	cytoplasm ; integral component of membrane ; endosome ; Golgi apparatus ; multivesicular body membrane ; intracellular membrane-bounded organelle ; membrane ; Golgi membrane ; endoplasmic reticulum ; mitochondrion ; perinuclear region of cytoplasm ; endosome membrane ;
Biological process	negative regulation of gene expression ; negative regulation of protein transport ; positive regulation of I-kappaB kinase/NF-kappaB signaling ; positive regulation of protein ubiquitination ; negative regulation of transporter activity ; signal transduction ; vacuolar transport ; metal ion transport ;
	Sources:Amigo / QuickGO
Orthologs
	54602
	76273
	ENSG00000102471
	ENSMUSG00000053253
	Q9NV92
	Q91ZP6
	NM_001161407 ; NM_019080 ; NM_001394685
	NM_001190989 ; NM_029561
	NP_001154879 ; NP_061953
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

NEDD4 family-interacting protein 2 is a protein that in humans is encoded by the NDFIP2 gene.^[5]^[6]^[7]

Interactions

NDFIP2 has been shown to interact with NEDD4.^[8]

Related Research Articles

E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 is an enzyme that is, in humans, encoded by the NEDD4 gene.

Neural precursor cell expressed developmentally downregulated gene 4-like (NEDD4L) or NEDD4-2 is an enzyme of the NEDD4 family. In human the protein is encoded by the NEDD4L gene. In mouse the protein is commonly known as NEDD4-2 and the gene Nedd4-2.

Calcium/calmodulin-dependent protein kinase type IV is an enzyme that in humans is encoded by the CAMK4 gene.

Lysophosphatidic acid receptor 2 also known as LPA₂ is a protein that in humans is encoded by the LPAR2 gene. LPA₂ is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Megakaryocyte-associated tyrosine-protein kinase is an enzyme that in humans is encoded by the MATK gene.

E3 ubiquitin-protein ligase SMURF1 is an enzyme that in humans is encoded by the SMURF1 gene.

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.

Growth factor receptor-bound protein 14 is a protein that in humans is encoded by the GRB14 gene.

AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.

NEDD4-like E3 ubiquitin-protein ligase WWP2 also known as atrophin-1-interacting protein 2 (AIP2) or WW domain-containing protein 2 (WWP2) is an enzyme that in humans is encoded by the WWP2 gene.

Helicase SRCAP is an enzyme that in humans is encoded by the SRCAP gene.

Prostaglandin F2 receptor negative regulator is a protein that in humans is encoded by the PTGFRN gene. PTGFRN has also been designated as CD315.

snRNA-activating protein complex subunit 1 is a protein that in humans is encoded by the SNAPC1 gene.

Dual specificity protein phosphatase 16 is an enzyme that in humans is encoded by the DUSP16 gene.

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.

Gamma-1-syntrophin is a protein that in humans is encoded by the SNTG1 gene.

Conserved oligomeric Golgi complex subunit 1 is a protein that in humans is encoded by the COG1 gene.

Sentrin-specific protease 8 is an enzyme that in humans is encoded by the SENP8 gene.

GDP-mannose 4,6 dehydratase is an enzyme that in humans is encoded by the GMDS gene.

WW domain-binding protein 1 is a protein that in humans is encoded by the WBP1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000102471 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053253 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID 10574461.
↑ Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S (Aug 2002). "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein". J Biol Chem. 277 (33): 29406–16. doi: 10.1074/jbc.M203018200 . PMID 12050153.
↑ "Entrez Gene: NDFIP2 Nedd4 family interacting protein 2".
↑ Cristillo, Anthony D; Nie Linghu; Macri Mirtha J; Bierer Barbara E (Sep 2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. 278 (36): 34587–97. doi: 10.1074/jbc.M304723200 . ISSN 0021-9258. PMID 12796489.

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi: 10.1038/sj.onc.1206406 . PMID 12761501.
Cristillo AD, Nie L, Macri MJ, Bierer BE (2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. 278 (36): 34587–97. doi: 10.1074/jbc.M304723200 . PMID 12796489.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC 2665288 . PMID 15057823.
Shearwin-Whyatt LM, Brown DL, Wylie FG, et al. (2005). "N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking". J. Cell Sci. 117 (Pt 16): 3679–89. doi: 10.1242/jcs.01212 . PMID 15252135.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000102471 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000053253 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10574461-5] Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID 10574461.

[pmid12050153-6] Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S (Aug 2002). "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein". J Biol Chem. 277 (33): 29406–16. doi: 10.1074/jbc.M203018200 . PMID 12050153.

[entrez-7] "Entrez Gene: NDFIP2 Nedd4 family interacting protein 2".

[pmid12796489-8] Cristillo, Anthony D; Nie Linghu; Macri Mirtha J; Bierer Barbara E (Sep 2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. 278 (36): 34587–97. doi: 10.1074/jbc.M304723200 . ISSN 0021-9258. PMID 12796489.

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NDFIP2

Contents

Interactions

Related Research Articles

References

Further reading