NDFIP2

NDFIP2
Identifiers
Aliases	NDFIP2 , N4WBP5A, Nedd4 family interacting protein 2
External IDs	OMIM: 610041; MGI: 1923523; HomoloGene: 12636; GeneCards: NDFIP2; OMA:NDFIP2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human) [1] Band 13q31.1 Start 79,481,124 bp [1] End 79,556,077 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 E2.3 Start 105,496,008 bp [2] End 105,546,732 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte skin of arm sperm pancreatic epithelial cell Brodmann area 46 mucosa of ileum skin of thigh palpebral conjunctiva jejunal mucosa pons Top expressed in habenula deep cerebellar nuclei medial vestibular nucleus olfactory tubercle submandibular gland ventral tegmental area pontine nuclei lateral geniculate nucleus left colon globus pallidus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity protein binding WW domain binding Cellular component cytoplasm integral component of membrane endosome Golgi apparatus multivesicular body membrane intracellular membrane-bounded organelle membrane Golgi membrane endoplasmic reticulum mitochondrion perinuclear region of cytoplasm endosome membrane Biological process negative regulation of gene expression negative regulation of protein transport positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of protein ubiquitination negative regulation of transporter activity signal transduction vacuolar transport metal ion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54602 76273 Ensembl ENSG00000102471 ENSMUSG00000053253 UniProt Q9NV92 Q91ZP6 RefSeq (mRNA) NM_001161407 NM_019080 NM_001394685 NM_001190989 NM_029561 RefSeq (protein) NP_001154879 NP_061953 n/a Location (UCSC) Chr 13: 79.48 – 79.56 Mb Chr 14: 105.5 – 105.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

NEDD4 family-interacting protein 2 is a protein that in humans is encoded by the NDFIP2 gene. ^{[5] [6] [7]}

Interactions

NDFIP2 has been shown to interact with NEDD4. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000102471 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000053253 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hirosawa M, Nagase T, Ishikawa K, Kikuno R, Nomura N, Ohara O (Jan 2000). "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain". DNA Res. 6 (5): 329–36. doi: 10.1093/dnares/6.5.329 . PMID   10574461.
6. Konstas AA, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C, Kumar S (Aug 2002). "Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-2-interacting protein". J Biol Chem. 277 (33): 29406–16. doi: 10.1074/jbc.M203018200 . PMID   12050153.
7. "Entrez Gene: NDFIP2 Nedd4 family interacting protein 2".
8. Cristillo AD, Nie Linghu, Macri Mirtha J, Bierer Barbara E (Sep 2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. 278 (36): 34587–97. doi: 10.1074/jbc.M304723200 . ISSN   0021-9258. PMID   12796489.

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Matsuda A, Suzuki Y, Honda G, et al. (2003). "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways". Oncogene. 22 (21): 3307–18. doi:10.1038/sj.onc.1206406. PMID   12761501. S2CID   38880905.
• Cristillo AD, Nie L, Macri MJ, Bierer BE (2003). "Cloning and characterization of N4WBP5A, an inducible, cyclosporine-sensitive, Nedd4-binding protein in human T lymphocytes". J. Biol. Chem. 278 (36): 34587–97. doi: 10.1074/jbc.M304723200 . PMID   12796489.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Dunham A, Matthews LH, Burton J, et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. Bibcode:2004Natur.428..522D. doi:10.1038/nature02379. PMC   2665288 . PMID   15057823.
• Shearwin-Whyatt LM, Brown DL, Wylie FG, et al. (2005). "N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking". J. Cell Sci. 117 (Pt 16): 3679–89. doi: 10.1242/jcs.01212 . hdl: 2440/9578 . PMID   15252135.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.