NEGR1

Last updated
NEGR1
Identifiers
Aliases NEGR1 , DMML2433, IGLON4, KILON, Ntra, neuronal growth regulator 1
External IDs OMIM: 613173 MGI: 2444846 HomoloGene: 41447 GeneCards: NEGR1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_173808

NM_001039094
NM_177274

RefSeq (protein)

NP_776169

NP_001034183
NP_796248

Location (UCSC) Chr 1: 71.4 – 72.28 Mb Chr 3: 156.27 – 157.02 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuronal growth regulator 1 also known as NEGR1 is a protein which in humans is encoded by the NEGR1 gene. [5]

Contents

Clinical significance

Variants of the NEGR1 gene may be associated with obesity and major depression. [6] [7] [8]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000172260 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000040037 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Funatsu N, Miyata S, Kumanogoh H, Shigeta M, Hamada K, Endo Y, Sokawa Y, Maekawa S (March 1999). "Characterization of a novel rat brain glycosylphosphatidylinositol-anchored protein (Kilon), a member of the IgLON cell adhesion molecule family". J. Biol. Chem. 274 (12): 8224–30. doi: 10.1074/jbc.274.12.8224 . PMID   10075727.
  6. Thorleifsson G, Walters GB, Gudbjartsson DF, et al. (January 2009). "Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity". Nat. Genet. 41 (1): 18–24. doi:10.1038/ng.274. PMID   19079260. S2CID   764409.
  7. Willer CJ, Speliotes EK, Loos RJ, et al. (January 2009). "Six new loci associated with body mass index highlight a neuronal influence on body weight regulation". Nat. Genet. 41 (1): 24–34. doi:10.1038/ng.287. PMC   2695662 . PMID   19079261.
  8. Zhao J, Bradfield JP, Li M, et al. (May 2009). "The role of obesity-associated loci identified in genome wide association studies in the determination of pediatric BMI". Obesity (Silver Spring). 17 (12): 2254–7. doi:10.1038/oby.2009.159. PMC   2860782 . PMID   19478790.

Further reading