NEMF (gene)

NEMF
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3J92
Identifiers
Aliases	NEMF , NY-CO-1, SDCCAG1, nuclear export mediator factor, IDDSAPN
External IDs	OMIM: 608378 MGI: 1918305 HomoloGene: 3458 GeneCards: NEMF
Gene location (Human)
Chr.	Chromosome 14 (human)
End	49,852,821 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	69,403,939 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; internal globus pallidus; ; sperm; ; Brodmann area 23; ; pylorus; ; corpus callosum; ; external globus pallidus; ; sural nerve; ; inferior ganglion of vagus nerve; ; oocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	tRNA binding ; ribosomal large subunit binding ;
Cellular component	nucleus ; RQC complex ;
Biological process	nuclear export ; rescue of stalled ribosome ; ribosome-associated ubiquitin-dependent protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	9147
	66244
	ENSG00000165525
	ENSMUSG00000020982
	O60524
	Q8CCP0
	NM_001301732 ; NM_004713
	NM_025441 ; NM_181665
	NP_001288661 ; NP_004704
	NP_079717
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated May 27, 2022

Nuclear export mediator factor (NEMF) is a protein that in humans is encoded by the NEMF gene.^[5]

Function

This gene encodes a component of the ribosome quality control complex.^[6] The encoded protein facilitates the recognition and ubiquitination of stalled 60S subunits by the ubiquitin ligase listerin. A similar protein in fly functions as a tumor suppressor.

Related Research Articles

NTF2-related export protein 1 is a protein that in humans is encoded by the NXT1 gene.

Nucleoporin GLE1 is a protein that in humans is encoded by the GLE1 gene on chromosome 9.

Nucleoporin 155 (Nup155) is a protein that in humans is encoded by the NUP155 gene.

Exportin-T is a protein that in humans is encoded by the XPOT gene.

28S ribosomal protein S35, mitochondrial is a protein that in humans is encoded by the MRPS35 gene.

Gem-associated protein 8 (Gemin-8) is a protein that in humans is encoded by the GEMIN8 gene.

Mitochondrial ribosomal protein L3 is a protein that in humans is encoded by the MRPL3 gene.

Integrator complex subunit 1 is a protein that in humans is encoded by the INTS1 gene.

Mitochondrial inner membrane protein OXA1L is a protein that in humans is encoded by the OXA1L gene located on 14q11.2. The C-terminus of this protein interacts with mitochondrial ribosomes and helps insert both mitochondrial and nuclear produced proteins into the inner membrane of the mitochondria.

Density regulated re-initiation and release factor (DENR) is a protein that in humans is encoded by the DENR gene.

Zinc finger protein 598 (ZNF598) is a protein that in humans is encoded by the ZNF598 gene.

Listerin E3 ubiquitin protein ligase 1 (LTN1), otherwise known as listerin, is a protein that in humans is encoded by the LTN1 gene.

Mediator complex subunit 9 (Med9) is a protein that in humans is encoded by the MED9 gene.

Mediator complex subunit 11 (Med11) is a protein that in humans is encoded by the MED11 gene.

Mediator complex subunit 18 (Med18) is a protein that in humans is encoded by the MED18 gene.

Mitochondrial ribosomal protein S2 (MRPS2), otherwise known as uS2m, is a protein that in humans is encoded by the MRPS2 gene.

Mitochondrial ribosomal protein S9 (MRPS9), otherwise known as uS9m, is a protein that in humans is encoded by the MRPS9 gene.

DDB1 and CUL4 associated factor 8 is a protein that in humans is encoded by the DCAF8 gene.

Ribosome-releasing factor 2, mitochondrial is a protein that in humans is encoded by the GFM2 gene. Unlike the other EF-G homolog GFM1, GFM2 functions as a Ribosome Recycling Factor in termination.

TSR2 ribosome maturation factor is a protein that in humans is encoded by the TSR2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000165525 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020982 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Nuclear export mediator factor".
↑ Shao S, Brown A, Santhanam B, Hegde RS (February 2015). "Structure and assembly pathway of the ribosome quality control complex". Molecular Cell. 57 (3): 433–44. doi:10.1016/j.molcel.2014.12.015. PMC 4321881 . PMID 25578875.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000165525 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020982 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Nuclear export mediator factor".

[Shao_Brown_Santhanam_Hegde_2015_pp._433–444-6] Shao S, Brown A, Santhanam B, Hegde RS (February 2015). "Structure and assembly pathway of the ribosome quality control complex". Molecular Cell. 57 (3): 433–44. doi:10.1016/j.molcel.2014.12.015. PMC 4321881 . PMID 25578875.

[1]

[2]

[3]

[4]

[5]

[6]