NEURL

NEURL1
Identifiers
Aliases	NEURL1 , NEUR1, NEURL, RNF67, bA416N2.1, neu, neu-1, neuralized E3 ubiquitin protein ligase 1
External IDs	OMIM: 603804 MGI: 1334263 HomoloGene: 32503 GeneCards: NEURL1
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.33 Start 103,493,705 bp [1] End 103,592,546 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 C3|19 39.39 cM Start 47,167,259 bp [2] End 47,247,880 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle cingulate gyrus prefrontal cortex nucleus accumbens Brodmann area 9 amygdala Brodmann area 10 putamen caudate nucleus frontal pole Top expressed in superior frontal gyrus triceps brachii muscle temporal muscle sternocleidomastoid muscle skeletal muscle tissue digastric muscle vastus lateralis muscle extraocular muscle cerebellar cortex gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function translation factor activity, non-nucleic acid binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity transferase activity Cellular component cytoplasm perikaryon postsynaptic membrane cell projection membrane postsynaptic density plasma membrane dendritic spine synapse cell junction dendrite perinuclear region of cytoplasm apical dendrite Biological process Notch signaling pathway flagellated sperm motility positive regulation of epidermal growth factor-activated receptor activity positive regulation of dendritic spine development protein monoubiquitination nervous system development sperm axoneme assembly positive regulation of synapse maturation brain development positive regulation of long-term neuronal synaptic plasticity protein ubiquitination positive regulation of apoptotic process cellular response to amino acid stimulus lactation skeletal muscle tissue development positive regulation of filopodium assembly regulation of translation negative regulation of cell population proliferation negative regulation of Notch signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9148 18011 Ensembl ENSG00000107954 ENSMUSG00000006435 UniProt O76050 Q923S6 RefSeq (mRNA) NM_004210 NM_001163480 NM_021360 RefSeq (protein) NP_004201 NP_001156952 NP_067335 Location (UCSC) Chr 10: 103.49 – 103.59 Mb Chr 19: 47.17 – 47.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuralized-like protein 1 is a protein that in humans is encoded by the NEURL gene. ^{[5] [6]}

See also

• NEURL2 (gene)

References

1. GRCh38: Ensembl release 89: ENSG00000107954 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006435 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nakamura H, Yoshida M, Tsuiki H, Ito K, Ueno M, Nakao M, Oka K, Tada M, Kochi M, Kuratsu J, Ushio Y, Saya H (Apr 1998). "Identification of a human homolog of the Drosophila neuralized gene within the 10q25.1 malignant astrocytoma deletion region". Oncogene. 16 (8): 1009–19. doi: 10.1038/sj.onc.1201618 . PMID   9519875.
6. "Entrez Gene: NEURL neuralized homolog (Drosophila)".

Further reading

• Kile BT, Schulman BA, Alexander WS, et al. (2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem. Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID   12076535.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi: 10.1038/nature02462 . PMID   15164054.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Timmusk T, Palm K, Belluardo N, et al. (2002). "Dendritic localization of mammalian neuralized mRNA encoding a protein with transcription repression activities". Mol. Cell. Neurosci. 20 (4): 649–68. doi:10.1006/mcne.2002.1148. PMID   12213446. S2CID   25771738.
• Pavlopoulos E, Kokkinaki M, Koutelou E, et al. (2002). "Cloning, chromosomal organization and expression analysis of Neurl, the mouse homolog of Drosophila melanogaster neuralized gene". Biochim. Biophys. Acta. 1574 (3): 375–82. doi:10.1016/s0167-4781(01)00330-x. PMID   11997106.
• Vollrath B, Pudney J, Asa S, et al. (2001). "Isolation of a Murine Homologue of the Drosophila neuralized Gene, a Gene Required for Axonemal Integrity in Spermatozoa and Terminal Maturation of the Mammary Gland". Mol. Cell. Biol. 21 (21): 7481–94. doi:10.1128/MCB.21.21.7481-7494.2001. PMC   99920 . PMID   11585928.