NEURL2

NEURL2
Identifiers
Aliases	NEURL2 , C20orf163, OZZ, OZZ-E3, neuralized E3 ubiquitin protein ligase 2
External IDs	OMIM: 608597 MGI: 3043305 HomoloGene: 15435 GeneCards: NEURL2
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,891,208 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,675,376 bp
RNA expression pattern
	Top expressed in
	gastric mucosa; ; thymus; ; gastrocnemius muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; left adrenal gland; ; right coronary artery; ; right lobe of liver; ; left coronary artery; ; left uterine tube;
	Top expressed in
	interventricular septum; ; vastus lateralis muscle; ; triceps brachii muscle; ; temporal muscle; ; myocardium of ventricle; ; ankle; ; sternocleidomastoid muscle; ; digastric muscle; ; skeletal muscle tissue; ; knee joint;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin protein ligase activity ;
Cellular component	cytoplasm ; cytosol ;
Biological process	intracellular signal transduction ; protein ubiquitination ; post-translational protein modification ;
	Sources:Amigo / QuickGO
Orthologs
	140825
	415115
	ENSG00000124257
	ENSMUSG00000039873
	Q9BR09
	Q9D0S4
	NM_080749 ; NM_001278535
	NM_001082974
	NP_001265464 ; NP_542787
	NP_001076443
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated January 18, 2024

Neuralized-like protein 2 is a protein that in humans is encoded by the NEURL2 gene.^[5]^[6]

Function

This gene encodes a protein that is involved in the regulation of myofibril organization. This protein is likely the adaptor component of the E3 ubiquitin ligase complex in striated muscle, and it regulates the ubiquitin-mediated degradation of beta-catenin during myogenesis.^[6]

Related Research Articles

G-protein coupled receptor 4 is a protein that in humans is encoded by the GPR4 gene.

Probable G-protein coupled receptor 78 is a protein that in humans is encoded by the GPR78 gene.

40S ribosomal protein S27a is a protein that in humans is encoded by the RPS27A gene.

E3 ubiquitin-protein ligase CHFR is an enzyme that in humans is encoded by the CHFR gene.

Homeobox protein DLX-4 is a protein that in humans is encoded by the DLX4 gene.

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.

DNA polymerase delta subunit 2 is an enzyme that in humans is encoded by the POLD2 gene. It is a component of the DNA polymerase delta complex.

The human gene UBR1 encodes the enzyme ubiquitin-protein ligase E3 component n-recognin 1.

CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA4 gene.

Ubiquilin-2 is a protein that in humans is encoded by the UBQLN2 gene.

60S ribosomal protein L21 is a protein that in humans is encoded by the RPL21 gene.

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.

Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene.

Tripartite motif-containing protein 32 is a protein that in humans is encoded by the TRIM32 gene. Since its discovery in 1995, TRIM32 has been shown to be implicated in a number of diverse biological pathways.

WD repeat domain phosphoinositide-interacting protein 2 is a protein that in humans is encoded by the WIPI2 gene.

Receptor-type tyrosine-protein phosphatase O is an enzyme that in humans is encoded by the PTPRO gene.

Enhancer of mRNA-decapping protein 3 is a protein that in humans is encoded by the EDC3 gene.

KN motif and ankyrin repeat domain-containing protein 1 is a protein that in humans is encoded by the KANK1 gene.

Sialidase-2 is an enzyme that in humans is encoded by the NEU2 gene.

Protein cornichon homolog is a protein that in humans is encoded by the CNIH gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124257 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039873 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.
1 2 "Entrez Gene: NEURL2 neuralized homolog 2 (Drosophila)".

Song R, Koo BK, Yoon KJ, et al. (2007). "Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1". J. Biol. Chem. 281 (47): 36391–400. doi: 10.1074/jbc.M606601200 . PMID 17003037.{{cite journal}}: CS1 maint: overridden setting (link)
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.{{cite journal}}: CS1 maint: overridden setting (link)
Nastasi T, Bongiovanni A, Campos Y, et al. (2004). "Ozz-E3, a muscle-specific ubiquitin ligase, regulates beta-catenin degradation during myogenesis". Dev. Cell. 6 (2): 269–82. doi: 10.1016/S1534-5807(04)00020-6 . PMID 14960280.{{cite journal}}: CS1 maint: overridden setting (link)
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.{{cite journal}}: CS1 maint: overridden setting (link)
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.{{cite journal}}: CS1 maint: overridden setting (link)
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.{{cite journal}}: CS1 maint: overridden setting (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124257 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039873 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12076535-5] Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci. 27 (5): 235–41. doi:10.1016/S0968-0004(02)02085-6. PMID 12076535.

[entrez-6] 1 2 "Entrez Gene: NEURL2 neuralized homolog 2 (Drosophila)".

[1]

[2]

[3]

[4]

[5]

[6]

NEURL2

Contents

Function

See also

Related Research Articles

References

Further reading