NGFRAP1

BEX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SA6
Identifiers
Aliases	BEX3 , Bex, DXS6984E, HGR74, NADE, NGFRAP1, brain expressed X-linked 3
External IDs	OMIM: 300361; MGI: 1338016; HomoloGene: 7642; GeneCards: BEX3; OMA:BEX3 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq22.2 Start 103,376,395 bp [1] End 103,378,164 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X F1|X 57.64 cM Start 135,171,002 bp [2] End 135,172,727 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cerebellar vermis pons superior vestibular nucleus middle temporal gyrus Brodmann area 23 ventral tegmental area renal medulla lateral nuclear group of thalamus pars compacta pars reticulata Top expressed in yolk sac somite mandibular prominence maxillary prominence dentate gyrus of hippocampal formation granule cell arcuate nucleus supraoptic nucleus central gray substance of midbrain superior cervical ganglion abdominal wall More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cysteine-type endopeptidase activator activity involved in apoptotic process nerve growth factor receptor binding death receptor binding protein binding metal ion binding identical protein binding Cellular component cytoplasm nucleus cytosol Biological process multicellular organism development activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process extrinsic apoptotic signaling pathway via death domain receptors apoptotic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27018 12070 Ensembl ENSG00000166681 ENSMUSG00000046432 UniProt Q00994 Q9WTZ9 RefSeq (mRNA) NM_206917 NM_001282674 NM_014380 NM_206915 NM_001110233 NM_001110234 NM_009750 RefSeq (protein) NP_001269603 NP_055195 NP_996798 NP_996800 NP_001103703 NP_001103704 NP_033880 Location (UCSC) Chr X: 103.38 – 103.38 Mb Chr X: 135.17 – 135.17 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein BEX3 is a protein that in humans is encoded by the NGFRAP1 gene. ^{[5] [6] [7]}

Interactions

NGFRAP1 has been shown to interact with YWHAE ^[8] and Low affinity nerve growth factor receptor. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000166681 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046432 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA (Jul 2000). "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR". J. Biol. Chem. 275 (23): 17566–70. doi: 10.1074/jbc.C000140200 . PMID   10764727.
6. Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, Scheit KH (Dec 1990). "Characterization of three abundant mRNAs from human ovarian granulosa cells". DNA Cell Biol. 9 (7): 479–85. doi:10.1089/dna.1990.9.479. hdl: 11858/00-001M-0000-0013-0D4C-0 . PMID   2171551.
7. "Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1".
8. Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi: 10.1074/jbc.M005453200 . PMID   11278287.

Further reading

• Auffray C, Behar G, Bois F, Bouchier C, Da Silva C, Devignes MD, Duprat S, Houlgatte R, Jumeau MN, Lamy B (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID   7757816.
• Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi: 10.1074/jbc.274.42.30202 . PMID   10514511.
• Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA (1999). "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation". FEBS Lett. 460 (2): 191–8. doi: 10.1016/S0014-5793(99)01324-1 . PMID   10544233.
• Bilderback TR, Gazula VR, Dobrowsky RT (2001). "Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways". J. Neurochem. 76 (5): 1540–51. doi:10.1046/j.1471-4159.2001.00171.x. PMID   11238738. S2CID   37832858.
• Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi: 10.1074/jbc.M005453200 . PMID   11278287.
• Mukai J, Shoji S, Kimura MT, Okubo S, Sano H, Suvanto P, Li Y, Irie S, Sato TA (2002). "Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis". J. Biol. Chem. 277 (16): 13973–82. doi: 10.1074/jbc.M106342200 . PMID   11830582.
• Tong X, Xie D, Roth W, Reed J, Koeffler HP (2003). "NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". Int. J. Oncol. 22 (6): 1357–62. doi:10.3892/ijo.22.6.1357. PMID   12739005.
• Yoon K, Jang HD, Lee SY (2004). "Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis". Biochem. Biophys. Res. Commun. 319 (2): 649–54. doi:10.1016/j.bbrc.2004.05.043. PMID   15178455.
• Alvarez E, Zhou W, Witta SE, Freed CR (2005). "Characterization of the Bex gene family in humans, mice, and rats". Gene. 357 (1): 18–28. doi:10.1016/j.gene.2005.05.012. PMID   15958283.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Yu Y, Wang J, Yuan H, Qin F, Wang J, Zhang N, Li YY, Liu J, Lu H (2006). "Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE". Brain Res. 1100 (1): 13–20. doi:10.1016/j.brainres.2006.05.010. PMID   16777077. S2CID   34177609.
• Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, Takamura A, Nanba E, Higaki K, Ohno K (2007). "The TSC1 gene product hamartin interacts with NADE". Mol. Cell. Neurosci. 35 (1): 100–8. doi:10.1016/j.mcn.2007.02.007. PMID   17355907. S2CID   24058959.