NGFRAP1

BEX3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1SA6
Identifiers
Aliases	BEX3 , Bex, DXS6984E, HGR74, NADE, NGFRAP1, brain expressed X-linked 3
External IDs	OMIM: 300361 MGI: 1338016 HomoloGene: 7642 GeneCards: BEX3
Gene location (Human)
Chr.	X chromosome (human)
End	103,378,164 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	135,172,727 bp
RNA expression pattern
	Top expressed in
	cerebellar vermis; ; pons; ; superior vestibular nucleus; ; middle temporal gyrus; ; Brodmann area 23; ; ventral tegmental area; ; renal medulla; ; glomerulus; ; inferior ganglion of vagus nerve; ; orbitofrontal cortex;
	Top expressed in
	yolk sac; ; somite; ; maxillary prominence; ; arcuate nucleus; ; supraoptic nucleus; ; superior cervical ganglion; ; abdominal wall; ; ventromedial nucleus; ; paraventricular nucleus of hypothalamus; ; dorsomedial hypothalamic nucleus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cysteine-type endopeptidase activator activity involved in apoptotic process ; nerve growth factor receptor binding ; death receptor binding ; protein binding ; metal ion binding ; identical protein binding ;
Cellular component	cytoplasm ; nucleus ; cytosol ;
Biological process	multicellular organism development ; activation of cysteine-type endopeptidase activity involved in apoptotic process ; regulation of cysteine-type endopeptidase activity involved in apoptotic process ; extrinsic apoptotic signaling pathway via death domain receptors ; apoptotic process ; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ;
	Sources:Amigo / QuickGO
Orthologs
	27018
	12070
	ENSG00000166681
	ENSMUSG00000046432
	Q00994
	Q9WTZ9
	NM_206917 ; NM_001282674 ; NM_014380 ; NM_206915
	NM_001110233 ; NM_001110234 ; NM_009750
	NP_001269603 ; NP_055195 ; NP_996798 ; NP_996800
	NP_001103703 ; NP_001103704 ; NP_033880
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 05, 2022

Protein BEX3 is a protein that in humans is encoded by the NGFRAP1 gene.^[5]^[6]^[7]

Interactions

NGFRAP1 has been shown to interact with YWHAE ^[8] and Low affinity nerve growth factor receptor.^[5]

Related Research Articles

The p75 neurotrophin receptor (p75NTR) was first identified in 1973 as the low-affinity nerve growth factor receptor (LNGFR) before discovery that p75NTR bound other neurotrophins equally well as nerve growth factor. p75NTR is a neurotrophic factor receptor. Neurotrophic factor receptors bind Neurotrophins including Nerve growth factor, Neurotrophin-3, Brain-derived neurotrophic factor, and Neurotrophin-4. All neurotrophins bind to p75NTR. This also includes the immature pro-neurotrophin forms. Neurotrophic factor receptors, including p75NTR, are responsible for ensuring a proper density to target ratio of developing neurons, refining broader maps in development into precise connections. p75NTR is involved in pathways that promote neuronal survival and neuronal death.

Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.

Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene. ACVR2A is an activin type 2 receptor.

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor.

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.

DNA replication licensing factor MCM2 is a protein that in humans is encoded by the MCM2 gene.

DNA replication licensing factor MCM4 is a protein that in humans is encoded by the MCM4 gene.

14-3-3 protein epsilon is a protein that in humans is encoded by the YWHAE gene.

Alpha-actinin-1 is a protein that in humans is encoded by the ACTN1 gene.

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.

Tyrosine-protein phosphatase non-receptor type 13 is an enzyme that in humans is encoded by the PTPN13 gene.

Melanoma-associated antigen D1 is a protein that in humans is encoded by the MAGED1 gene.

Necdin is a protein that in humans is encoded by the NDN gene.

TNF receptor-associated factor 4 (TRAF4) also known as RING finger protein 83 (RNF83) is a protein that in humans is encoded by the TRAF4 gene.

Serine/threonine-protein kinase D2 or PKD2 is an enzyme that in humans is encoded by the PRKD2 gene.

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.

Lin-7 homolog B is a protein that in humans is encoded by the LIN7B gene.

Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13 is a protein that in humans is encoded by the GNG13 gene.

Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.

FYVE, RhoGEF and PH domain-containing protein 2 (FGD2), also known as zinc finger FYVE domain-containing protein 4 (ZFYVE4), is a protein that in humans is encoded by the FGD2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166681 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046432 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA (Jul 2000). "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR". J. Biol. Chem. 275 (23): 17566–70. doi: 10.1074/jbc.C000140200 . PMID 10764727.
↑ Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, Scheit KH (Dec 1990). "Characterization of three abundant mRNAs from human ovarian granulosa cells". DNA Cell Biol. 9 (7): 479–85. doi:10.1089/dna.1990.9.479. hdl: 11858/00-001M-0000-0013-0D4C-0 . PMID 2171551.
↑ "Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1".
↑ Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi: 10.1074/jbc.M005453200 . PMID 11278287.

Auffray C, Behar G, Bois F, Bouchier C, Da Silva C, Devignes MD, Duprat S, Houlgatte R, Jumeau MN, Lamy B (1995). "[IMAGE: molecular integration of the analysis of the human genome and its expression]". Comptes Rendus de l'Académie des Sciences, Série III. 318 (2): 263–72. PMID 7757816.
Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE (1999). "TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction". J. Biol. Chem. 274 (42): 30202–8. doi: 10.1074/jbc.274.42.30202 . PMID 10514511.
Irie S, Hachiya T, Rabizadeh S, Maruyama W, Mukai J, Li Y, Reed JC, Bredesen DE, Sato TA (1999). "Functional interaction of Fas-associated phosphatase-1 (FAP-1) with p75(NTR) and their effect on NF-kappaB activation". FEBS Lett. 460 (2): 191–8. doi: 10.1016/S0014-5793(99)01324-1 . PMID 10544233.
Bilderback TR, Gazula VR, Dobrowsky RT (2001). "Phosphoinositide 3-kinase regulates crosstalk between Trk A tyrosine kinase and p75(NTR)-dependent sphingolipid signaling pathways". J. Neurochem. 76 (5): 1540–51. doi:10.1046/j.1471-4159.2001.00171.x. PMID 11238738. S2CID 37832858.
Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi: 10.1074/jbc.M005453200 . PMID 11278287.
Mukai J, Shoji S, Kimura MT, Okubo S, Sano H, Suvanto P, Li Y, Irie S, Sato TA (2002). "Structure-function analysis of NADE: identification of regions that mediate nerve growth factor-induced apoptosis". J. Biol. Chem. 277 (16): 13973–82. doi: 10.1074/jbc.M106342200 . PMID 11830582.
Tong X, Xie D, Roth W, Reed J, Koeffler HP (2003). "NADE (p75NTR-associated cell death executor) suppresses cellular growth in vivo". Int. J. Oncol. 22 (6): 1357–62. doi:10.3892/ijo.22.6.1357. PMID 12739005.
Yoon K, Jang HD, Lee SY (2004). "Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis". Biochem. Biophys. Res. Commun. 319 (2): 649–54. doi:10.1016/j.bbrc.2004.05.043. PMID 15178455.
Alvarez E, Zhou W, Witta SE, Freed CR (2005). "Characterization of the Bex gene family in humans, mice, and rats". Gene. 357 (1): 18–28. doi:10.1016/j.gene.2005.05.012. PMID 15958283.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Yu Y, Wang J, Yuan H, Qin F, Wang J, Zhang N, Li YY, Liu J, Lu H (2006). "Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE". Brain Res. 1100 (1): 13–20. doi:10.1016/j.brainres.2006.05.010. PMID 16777077. S2CID 34177609.
Yasui S, Tsuzaki K, Ninomiya H, Floricel F, Asano Y, Maki H, Takamura A, Nanba E, Higaki K, Ohno K (2007). "The TSC1 gene product hamartin interacts with NADE". Mol. Cell. Neurosci. 35 (1): 100–8. doi:10.1016/j.mcn.2007.02.007. PMID 17355907. S2CID 24058959.

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166681 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046432 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10764727-5] 1 2 Mukai J, Hachiya T, Shoji-Hoshino S, Kimura MT, Nadano D, Suvanto P, Hanaoka T, Li Y, Irie S, Greene LA, Sato TA (Jul 2000). "NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR". J. Biol. Chem. 275 (23): 17566–70. doi: 10.1074/jbc.C000140200 . PMID 10764727.

[pmid2171551-6] Rapp G, Freudenstein J, Klaudiny J, Mucha J, Wempe F, Zimmer M, Scheit KH (Dec 1990). "Characterization of three abundant mRNAs from human ovarian granulosa cells". DNA Cell Biol. 9 (7): 479–85. doi:10.1089/dna.1990.9.479. hdl: 11858/00-001M-0000-0013-0D4C-0 . PMID 2171551.

[entrez-7] "Entrez Gene: NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1".

[pmid11278287-8] Kimura MT, Irie S, Shoji-Hoshino S, Mukai J, Nadano D, Oshimura M, Sato TA (May 2001). "14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction". J. Biol. Chem. 276 (20): 17291–300. doi: 10.1074/jbc.M005453200 . PMID 11278287.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

NGFRAP1

Contents

Interactions

Related Research Articles

References

Further reading