NHP2L1

Last updated
SNU13
Protein NHP2L1 PDB 1e7k.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SNU13 , 15.5K, FA-1, FA1, NHPX, OTK27, SNRNP15-5, SPAG12, SSFA1, NHP2L1, SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5), small nuclear ribonucleoprotein 13
External IDs OMIM: 601304 MGI: 893586 HomoloGene: 3672 GeneCards: SNU13
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001003796
NM_005008

NM_011482

RefSeq (protein)

NP_001003796
NP_004999

NP_035612

Location (UCSC) Chr 22: 41.67 – 41.69 Mb n/a
PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

NHP2-like protein 1 is a protein that in humans is encoded by the SNU13 gene. [4] [5]

Contents

Function

Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [5]

Interactions

SNU13 has been shown to interact with RAD17. [6]

Related Research Articles

<span class="mw-page-title-main">Spliceosome</span> Molecular machine that removes intron RNA from the primary transcript

A spliceosome is a large ribonucleoprotein (RNP) complex found primarily within the nucleus of eukaryotic cells. The spliceosome is assembled from small nuclear RNAs (snRNA) and numerous proteins. Small nuclear RNA (snRNA) molecules bind to specific proteins to form a small nuclear ribonucleoprotein complex, which in turn combines with other snRNPs to form a large ribonucleoprotein complex called a spliceosome. The spliceosome removes introns from a transcribed pre-mRNA, a type of primary transcript. This process is generally referred to as splicing. An analogy is a film editor, who selectively cuts out irrelevant or incorrect material from the initial film and sends the cleaned-up version to the director for the final cut.

snRNPs, or small nuclear ribonucleoproteins, are RNA-protein complexes that combine with unmodified pre-mRNA and various other proteins to form a spliceosome, a large RNA-protein molecular complex upon which splicing of pre-mRNA occurs. The action of snRNPs is essential to the removal of introns from pre-mRNA, a critical aspect of post-transcriptional modification of RNA, occurring only in the nucleus of eukaryotic cells. Additionally, U7 snRNP is not involved in splicing at all, as U7 snRNP is responsible for processing the 3′ stem-loop of histone pre-mRNA.

Small nuclear RNA (snRNA) is a class of small RNA molecules that are found within the splicing speckles and Cajal bodies of the cell nucleus in eukaryotic cells. The length of an average snRNA is approximately 150 nucleotides. They are transcribed by either RNA polymerase II or RNA polymerase III. Their primary function is in the processing of pre-messenger RNA (hnRNA) in the nucleus. They have also been shown to aid in the regulation of transcription factors or RNA polymerase II, and maintaining the telomeres.

<span class="mw-page-title-main">Coilin</span> Protein found in humans

Coilin is a protein that in humans is encoded by the COIL gene. Coilin got its name from the coiled shape of the Cajal bodies in which it is found. It was first identified using human autoimmune serum.

<span class="mw-page-title-main">U4 spliceosomal RNA</span> Non-coding RNA component of the spliceosome

The U4 small nuclear Ribo-Nucleic Acid is a non-coding RNA component of the major or U2-dependent spliceosome – a eukaryotic molecular machine involved in the splicing of pre-messenger RNA (pre-mRNA). It forms a duplex with U6, and with each splicing round, it is displaced from the U6 snRNA in an ATP-dependent manner, allowing U6 to re-fold and create the active site for splicing catalysis. A recycling process involving protein Brr2 releases U4 from U6, while protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved.

<span class="mw-page-title-main">Fibrillarin</span> Protein-coding gene in the species Homo sapiens

rRNA 2'-O-methyltransferase fibrillarin is an enzyme that in humans is encoded by the FBL gene.

<span class="mw-page-title-main">Small nucleolar RNA SNORD88</span>

In molecular biology, Small Nucleolar RNA SNORD88 is a non-coding RNA (ncRNA) molecule which functions in the biogenesis (modification) of other small nuclear RNAs (snRNAs). This type of modifying RNA is located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA.

<span class="mw-page-title-main">Small nuclear ribonucleoprotein D1</span> Protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein Sm D1 is a protein that in humans is encoded by the SNRPD1 gene.

<span class="mw-page-title-main">SNRPD3</span> Protein-coding gene in the species Homo sapiens

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene.

<span class="mw-page-title-main">PRPF3</span> Protein-coding gene in the species Homo sapiens

U4/U6 small nuclear ribonucleoprotein Prp3 is a protein that in humans is encoded by the PRPF3 gene.

<span class="mw-page-title-main">ASCC3L1</span> Protein-coding gene in the species Homo sapiens

U5 small nuclear ribonucleoprotein 200 kDa helicase is an enzyme that in humans is encoded by the SNRNP200 gene.

<span class="mw-page-title-main">SART3</span> Protein-coding gene in the species Homo sapiens

Squamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.

<span class="mw-page-title-main">SF3B2</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3B subunit 2 is a protein that in humans is encoded by the SF3B2 gene.

<span class="mw-page-title-main">PRPF4</span> Protein-coding gene in the species Homo sapiens

U4/U6 small nuclear ribonucleoprotein Prp4 is a protein that in humans is encoded by the PRPF4 gene. The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF4 is 1 of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM]

<span class="mw-page-title-main">NOL5A</span> Protein-coding gene in the species Homo sapiens

Nucleolar protein 56 is a protein that in humans is encoded by the NOP56 gene.

<span class="mw-page-title-main">Nucleolar protein, member A1</span> Protein-coding gene in the species Homo sapiens

H/ACA ribonucleoprotein complex subunit 1 is a protein that in humans is encoded by the GAR1 gene.

<span class="mw-page-title-main">SF3B14</span> Protein-coding gene in the species Homo sapiens

Splicing factor 3B, 14 kDa subunit, also known as SF3B14, is a human gene.

<span class="mw-page-title-main">WDR57</span> Protein-coding gene in the species Homo sapiens

WD repeat domain 57 , also known as WDR57, is a gene found in many organisms, including, but not limited to Homo sapiens, Gallus gallus, Pan troglodytes, Canus familiaris, Bos taurus, Mus musculus, and Rattus norvegicus.

<span class="mw-page-title-main">PPIH</span> Protein-coding gene in the species Homo sapiens

Peptidyl-prolyl cis-trans isomerase H is an enzyme that in humans is encoded by the PPIH gene.

<span class="mw-page-title-main">SPN1</span> Protein-coding gene in the species Homo sapiens

Snurportin1 is a protein that in humans is encoded by the SNUPN gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000100138 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. Saito H, Fujiwara T, Shin S, Okui K, Nakamura Y (Jan 1997). "Cloning and mapping of a human novel cDNA (NHP2L1) that encodes a protein highly homologous to yeast nuclear protein NHP2". Cytogenetics and Cell Genetics. 72 (2–3): 191–3. doi:10.1159/000134186. PMID   8978773.
  5. 1 2 "Entrez Gene: NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)".
  6. Chang MS, Sasaki H, Campbell MS, Kraeft SK, Sutherland R, Yang CY, Liu Y, Auclair D, Hao L, Sonoda H, Ferland LH, Chen LB (Dec 1999). "HRad17 colocalizes with NHP2L1 in the nucleolus and redistributes after UV irradiation". The Journal of Biological Chemistry. 274 (51): 36544–9. doi: 10.1074/jbc.274.51.36544 . PMID   10593953.

Further reading