NLGN2

NLGN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3BL8
Identifiers
Aliases	NLGN2 , neuroligin 2
External IDs	OMIM: 606479 MGI: 2681835 HomoloGene: 69317 GeneCards: NLGN2
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17p13.1 Start 7,404,874 bp [1] End 7,419,860 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B3 Start 69,713,948 bp [2] End 69,728,610 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus ganglionic eminence stromal cell of endometrium nucleus accumbens caudate nucleus myometrium left uterine tube putamen prefrontal cortex Brodmann area 9 Top expressed in subiculum dorsomedial hypothalamic nucleus piriform cortex superior colliculus internal carotid artery superior frontal gyrus cerebellar cortex cerebellar vermis habenula primary motor cortex More reference expression data BioGPS n/a
Gene ontology Molecular function carboxylic ester hydrolase activity neurexin family protein binding cell adhesion molecule binding signaling receptor activity identical protein binding Cellular component integral component of membrane postsynaptic membrane membrane synapse inhibitory synapse cell surface cell junction presynaptic membrane plasma membrane integral component of plasma membrane integral component of postsynaptic membrane intracellular anatomical structure spanning component of membrane glycinergic synapse dopaminergic synapse GABA-ergic synapse symmetric, GABA-ergic, inhibitory synapse integral component of postsynaptic specialization membrane Biological process neuromuscular process controlling balance neuron cell-cell adhesion positive regulation of inhibitory postsynaptic potential synapse organization modulation of chemical synaptic transmission positive regulation of protein localization to synapse gephyrin clustering involved in postsynaptic density assembly postsynaptic density protein 95 clustering positive regulation of synaptic transmission, GABAergic regulation of AMPA receptor activity locomotory exploration behavior regulation of respiratory gaseous exchange by nervous system process cell-cell junction maintenance positive regulation of synaptic vesicle clustering positive regulation of synaptic transmission, glutamatergic cell adhesion positive regulation of excitatory postsynaptic potential sensory perception of pain terminal button organization protein localization to synapse positive regulation of insulin secretion positive regulation of synapse assembly inhibitory synapse assembly synapse assembly synaptic vesicle endocytosis postsynaptic membrane assembly presynaptic membrane assembly cell-cell adhesion postsynaptic specialization assembly presynapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57555 216856 Ensembl ENSG00000169992 ENSG00000283859 ENSMUSG00000051790 UniProt Q8NFZ4 Q69ZK9 RefSeq (mRNA) NM_020795 NM_198862 NM_001364137 RefSeq (protein) NP_065846 NP_942562 NP_001351066 Location (UCSC) Chr 17: 7.4 – 7.42 Mb Chr 11: 69.71 – 69.73 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuroligin-2 is a protein that in humans is encoded by the NLGN2 gene. ^{[5] [6] [7]}

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. ^[7]

References

1. ENSG00000283859 GRCh38: Ensembl release 89: ENSG00000169992, ENSG00000283859 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000051790 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID   10767552.
6. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID   10819331.
7. "Entrez Gene: NLGN2 neuroligin 2".

Further reading

• Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ..." Curr. Biol. 10 (17): R620–3. doi: 10.1016/S0960-9822(00)00663-1 . PMID   10996085. S2CID   15851386.
• Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–82. doi: 10.1074/jbc.271.5.2676 . PMID   8576240.
• Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID   9278515.
• Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). "CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins". Mol. Cell. Neurosci. 11 (3): 161–72. doi:10.1006/mcne.1998.0679. PMID   9647694. S2CID   36534759.
• Nagase T, Kikuno R, Ishikawa KI, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi: 10.1093/dnares/7.1.65 . PMID   10718198.
• Scheiffele P, Fan J, Choih J, et al. (2000). "Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons". Cell. 101 (6): 657–69. doi: 10.1016/S0092-8674(00)80877-6 . PMID   10892652. S2CID   16095623.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMC   1925054 . PMID   12669065.