NLGN3

NLGN3
Identifiers
Aliases	NLGN3 , HNL3, neuroligin 3
External IDs	OMIM: 300336; MGI: 2444609; HomoloGene: 23133; GeneCards: NLGN3; OMA:NLGN3 - orthologs
Gene location (Human) Chr. X chromosome (human) [1] Band Xq13.1 Start 71,144,821 bp [1] End 71,175,255 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X|X D Start 100,342,774 bp [2] End 100,369,569 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone prefrontal cortex amygdala right frontal lobe ganglionic eminence cingulate gyrus anterior cingulate cortex nucleus accumbens caudate nucleus Brodmann area 9 Top expressed in dentate gyrus of hippocampal formation granule cell visual cortex primary visual cortex superior frontal gyrus supraoptic nucleus substantia nigra Region I of hippocampus proper hippocampus proper Rostral migratory stream neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function scaffold protein binding neurexin family protein binding carboxylic ester hydrolase activity cell adhesion molecule binding protein binding signaling receptor activity Cellular component integral component of membrane membrane cell surface synapse cell junction endocytic vesicle excitatory synapse plasma membrane integral component of plasma membrane integral component of postsynaptic membrane spanning component of membrane presynapse symmetric, GABA-ergic, inhibitory synapse asymmetric, glutamatergic, excitatory synapse Biological process regulation of AMPA receptor activity positive regulation of synaptic vesicle clustering social behavior rhythmic synaptic transmission regulation of NMDA receptor activity regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential positive regulation of AMPA receptor activity synapse organization negative regulation of excitatory postsynaptic potential modulation of chemical synaptic transmission regulation of respiratory gaseous exchange by nervous system process axon extension learning long-term potentiation vocalization behavior negative regulation of dendritic spine morphogenesis neuron cell-cell adhesion regulation of dendritic spine morphogenesis receptor-mediated endocytosis cell adhesion oligodendrocyte differentiation regulation of terminal button organization adult behavior positive regulation of excitatory postsynaptic potential positive regulation of synaptic transmission, glutamatergic regulation of long-term synaptic potentiation visual learning inhibitory postsynaptic potential positive regulation of synapse assembly synapse assembly synaptic vesicle endocytosis postsynaptic membrane assembly presynaptic membrane assembly presynapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54413 245537 Ensembl ENSG00000196338 ENSMUSG00000031302 UniProt Q9NZ94 Q8BYM5 RefSeq (mRNA) NM_001166660 NM_018977 NM_181303 NM_001321276 NM_172932 RefSeq (protein) NP_001160132 NP_001308205 NP_061850 NP_851820 NP_001160132.1 NP_766520 Location (UCSC) Chr X: 71.14 – 71.18 Mb Chr X: 100.34 – 100.37 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neuroligin-3 is a protein that in humans is encoded by the NLGN3 gene. ^{[5] [6] [7]}

This gene encodes a member of the neuroligin family of neuronal cell surface proteins. Neuroligins may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism spectrum disorders (ASDs). ^{[8] [9]} Multiple transcript variants encoding distinct isoforms have been identified for this gene, but their full length sequences have not been determined. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000196338 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031302 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Philibert RA, Winfield SL, Sandhu HK, Martin BM, Ginns EI (May 2000). "The structure and expression of the human neuroligin-3 gene". Gene. 246 (1–2): 303–10. doi:10.1016/S0378-1119(00)00049-4. PMID   10767552.
6. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O (Sep 2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID   10819331.
7. "Entrez Gene: NLGN3 neuroligin 3".
8. Uchigashima, Motokazu; Cheung, Amy; Futai, Kensuke (October 2021). "Neuroligin-3: A Circuit-Specific Synapse Organizer That Shapes Normal Function and Autism Spectrum Disorder-Associated Dysfunction". Fronts in Molecular Neuroscience. 6 (14). doi:10.3389/fnmol.2021.749164. PMC   8526735 . PMID   34690695.
9. Qin, Liming; Liu, Zhili; Guo, Sile; Han, Ying; Wang, Xiankun; et al. (January 2025). "Astrocytic Neuroligin-3 influences gene expression and social behavior, but is dispensable for synapse number". Molecular Psychiatry. 30 (1): 84–96. doi:10.1038/s41380-024-02659-6. PMC   11649564 . PMID   39003414.

Further reading

• Missler M, Fernandez-Chacon R, Südhof TC (1998). "The making of neurexins". J. Neurochem. 71 (4): 1339–47. doi: 10.1046/j.1471-4159.1998.71041339.x . PMID   9751164.
• Cantallops I, Cline HT (2000). "Synapse formation: if it looks like a duck and quacks like a duck ..." Curr. Biol. 10 (17): R620–3. doi: 10.1016/S0960-9822(00)00663-1 . PMID   10996085.
• Ichtchenko K, Nguyen T, Südhof TC (1996). "Structures, alternative splicing, and neurexin binding of multiple neuroligins". J. Biol. Chem. 271 (5): 2676–82. doi: 10.1074/jbc.271.5.2676 . PMID   8576240.
• Irie M, Hata Y, Takeuchi M, et al. (1997). "Binding of neuroligins to PSD-95". Science. 277 (5331): 1511–5. doi:10.1126/science.277.5331.1511. PMID   9278515.
• Nguyen T, Südhof TC (1997). "Binding properties of neuroligin 1 and neurexin 1beta reveal function as heterophilic cell adhesion molecules". J. Biol. Chem. 272 (41): 26032–9. doi: 10.1074/jbc.272.41.26032 . PMID   9325340.
• Gilbert M, Smith J, Roskams AJ, Auld VJ (2001). "Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia". Glia. 34 (3): 151–64. doi:10.1002/glia.1050. PMID   11329178. S2CID   19247385.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Jamain S, Quach H, Betancur C, et al. (2003). "Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism". Nat. Genet. 34 (1): 27–9. doi:10.1038/ng1136. PMC   1925054 . PMID   12669065.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Vincent JB, Kolozsvari D, Roberts WS, et al. (2005). "Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands". Am. J. Med. Genet. B Neuropsychiatr. Genet. 129 (1): 82–4. doi: 10.1002/ajmg.b.30069 . PMID   15274046. S2CID   24799609.
• Gauthier J, Bonnel A, St-Onge J, et al. (2005). "NLGN3/NLGN4 gene mutations are not responsible for autism in the Quebec population". Am. J. Med. Genet. B Neuropsychiatr. Genet. 132 (1): 74–5. doi:10.1002/ajmg.b.30066. PMID   15389766. S2CID   43148256.
• Yan J, Oliveira G, Coutinho A, et al. (2005). "Analysis of the neuroligin 3 and 4 genes in autism and other neuropsychiatric patients". Mol. Psychiatry. 10 (4): 329–32. doi:10.1038/sj.mp.4001629. hdl: 10400.18/346 . PMID   15622415. S2CID   17530049.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Blasi F, Bacchelli E, Pesaresi G, et al. (2006). "Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection". Am. J. Med. Genet. B Neuropsychiatr. Genet. 141 (3): 220–1. doi:10.1002/ajmg.b.30287. PMID   16508939. S2CID   42297317.
• Talebizadeh Z, Lam DY, Theodoro MF, et al. (2006). "Novel splice isoforms for NLGN3 and NLGN4 with possible implications in autism". J. Med. Genet. 43 (5): e21. doi:10.1136/jmg.2005.036897. PMC   2564526 . PMID   16648374.
• Yamakawa H, Oyama S, Mitsuhashi H, et al. (2007). "Neuroligins 3 and 4X interact with syntrophin-gamma2, and the interactions are affected by autism-related mutations". Biochem. Biophys. Res. Commun. 355 (1): 41–6. Bibcode:2007BBRC..355...41Y. doi:10.1016/j.bbrc.2007.01.127. PMID   17292328.