NPDC1

NPDC1
Identifiers
Aliases	NPDC1 , CAB, CAB-, CAB-1, CAB1, NPDC-1, neural proliferation, differentiation and control, 1, neural proliferation, differentiation and control 1
External IDs	OMIM: 605798; MGI: 1099802; HomoloGene: 32050; GeneCards: NPDC1; OMA:NPDC1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q34.3 Start 137,039,463 bp [1] End 137,046,179 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 A3 Start 25,289,363 bp [2] End 25,299,506 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum pituitary gland anterior pituitary right frontal lobe prostate Brodmann area 9 cerebellar vermis primary visual cortex hypothalamus right uterine tube Top expressed in dentate gyrus of hippocampal formation granule cell primary visual cortex superior frontal gyrus cerebellar cortex perirhinal cortex entorhinal cortex CA3 field superior colliculus ventromedial nucleus primary motor cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component membrane integral component of membrane plasma membrane Biological process regulation of immune response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56654 18146 Ensembl ENSG00000107281 ENSMUSG00000015094 UniProt Q9NQX5 Q64322 RefSeq (mRNA) NM_015392 NM_008721 RefSeq (protein) NP_056207 NP_032747 Location (UCSC) Chr 9: 137.04 – 137.05 Mb Chr 2: 25.29 – 25.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Neural proliferation differentiation and control protein 1 is a protein that in humans is encoded by the NPDC1 gene. ^{[5] [6]}

Interactions

NPDC1 has been shown to interact with E2F1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000107281 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000015094 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Qu X, Zhang C, Zhai Y, Xing G, Wei H, Yu Y, Wu S, He F (March 2001). "Characterization and tissue expression of a novel human gene npdc1". Gene. 264 (1): 37–44. doi:10.1016/S0378-1119(01)00324-9. PMID   11245976.
6. "Entrez Gene: NPDC1 neural proliferation, differentiation and control, 1".
7. Sansal I, Dupont E, Toru D, Evrard C, Rouget P (October 2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9. doi: 10.1038/sj.onc.1203843 . PMID   11042687.

Further reading

• Dupont E, Sansal I, Toru D, Evrard C, Rouget P (1997). "[Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors]". C. R. Séances Soc. Biol. Fil. 191 (1): 95–104. PMID   9181131.
• Galiana E, Vernier P, Dupont E, Evrard C, Rouget P (1995). "Identification of a neural-specific cDNA, NPDC-1, able to down-regulate cell proliferation and to suppress transformation". Proc. Natl. Acad. Sci. U.S.A. 92 (5): 1560–4. Bibcode:1995PNAS...92.1560G. doi: 10.1073/pnas.92.5.1560 . PMC   42559 . PMID   7878019.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Iwasaki K, Toyonaga R (2000). "The Rab3 GDP/GTP exchange factor homolog AEX-3 has a dual function in synaptic transmission". EMBO J. 19 (17): 4806–16. doi:10.1093/emboj/19.17.4806. PMC   302062 . PMID   10970871.
• Sansal I, Dupont E, Toru D, Evrard C, Rouget P (2000). "NPDC-1, a regulator of neural cell proliferation and differentiation, interacts with E2F-1, reduces its binding to DNA and modulates its transcriptional activity". Oncogene. 19 (43): 5000–9. doi: 10.1038/sj.onc.1203843 . PMID   11042687.
• Spencer ML, Theodosiou M, Noonan DJ (2004). "NPDC-1, a novel regulator of neuronal proliferation, is degraded by the ubiquitin/proteasome system through a PEST degradation motif". J. Biol. Chem. 279 (35): 37069–78. doi: 10.1074/jbc.M402507200 . PMID   15229225.
• Evrard C, Caron S, Rouget P (2004). "Functional analysis of the NPDC-1 gene". Gene. 343 (1): 153–63. doi:10.1016/j.gene.2004.08.020. PMID   15563841.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.