NPM3

NPM3
Identifiers
Aliases	NPM3 , PORMIN, TMEM123, nucleophosmin/nucleoplasmin 3
External IDs	OMIM: 606456; MGI: 894653; HomoloGene: 5083; GeneCards: NPM3; OMA:NPM3 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) [1] Band 10q24.32 Start 101,781,325 bp [1] End 101,783,413 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 C3|19 38.75 cM Start 45,736,173 bp [2] End 45,738,030 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte stromal cell of endometrium secondary oocyte gonad body of pancreas mucosa of transverse colon islet of Langerhans left adrenal cortex right adrenal gland right adrenal cortex Top expressed in epiblast spermatocyte thymus embryo yolk sac testicle lens ileum spermatid ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding RNA binding chromatin binding histone binding Cellular component nucleus nucleolus cytosol actin cytoskeleton nucleoplasm cytoplasm Biological process rRNA processing rRNA transcription chromatin remodeling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10360 18150 Ensembl ENSG00000107833 ENSMUSG00000056209 UniProt O75607 Q9CPP0 RefSeq (mRNA) NM_006993 NM_008723 RefSeq (protein) NP_008924 NP_032749 Location (UCSC) Chr 10: 101.78 – 101.78 Mb Chr 19: 45.74 – 45.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoplasmin-3 is a protein that in humans is encoded by the NPM3 gene. ^{[5] [6]}

The protein encoded by this gene is related to the nuclear chaperone phosphoproteins, nucleoplasmin and nucleophosmin. It is highly homologous to the murine Npm3 gene. Based on the structural similarity of the human NPM3 gene product to nucleoplasmin and nucleophosmin, NPM3 may represent a new member of this gene family, and may share basic functions with the molecular chaperones. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000107833 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000056209 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shackleford GM, Ganguly A, MacArthur CA (Jul 2003). "Cloning, expression and nuclear localization of human NPM3, a member of the nucleophosmin/nucleoplasmin family of nuclear chaperones". BMC Genomics. 2: 8. doi: 10.1186/1471-2164-2-8 . PMC   60000 . PMID   11722795.
6. "Entrez Gene: NPM3 nucleophosmin/nucleoplasmin, 3".

Further reading

• Philpott A, Krude T, Laskey RA (2000). "Nuclear chaperones". Semin. Cell Dev. Biol. 11 (1): 7–14. doi:10.1006/scdb.1999.0346. PMID   10736259.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID   15635413. S2CID   4344740.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• MacArthur CA, Shackleford GM (1997). "Npm3: a novel, widely expressed gene encoding a protein related to the molecular chaperones nucleoplasmin and nucleophosmin". Genomics. 42 (1): 137–40. doi:10.1006/geno.1997.4353. PMID   9177783.

External links

• NPM3 human gene location in the UCSC Genome Browser .
• NPM3 human gene details in the UCSC Genome Browser .