NPTN

NPTN
Identifiers
Aliases	NPTN , GP55, GP65, SDFR1, SDR1, np55, np65, neuroplastin
External IDs	OMIM: 612820 HomoloGene: 7531 GeneCards: NPTN
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q24.1 Start 73,560,014 bp [1] End 73,634,134 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 23 cerebellar vermis germinal epithelium jejunal mucosa bronchial epithelial cell visceral pleura orbitofrontal cortex caput epididymis tibia superior frontal gyrus n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane transporter binding fibroblast growth factor receptor binding cell adhesion molecule binding type 1 fibroblast growth factor receptor binding cell-cell adhesion mediator activity protein binding Cellular component integral component of membrane synaptic membrane membrane postsynaptic density plasma membrane inhibitory synapse dendrite presynaptic membrane cell surface axon Schaffer collateral - CA1 synapse glutamatergic synapse GABA-ergic synapse integral component of presynaptic active zone membrane integral component of postsynaptic density membrane immunological synapse Biological process visual learning positive regulation of long-term synaptic potentiation nervous system development cell adhesion positive regulation of protein localization positive regulation of ERK1 and ERK2 cascade positive regulation of long-term neuronal synaptic plasticity positive regulation of neuron projection development positive regulation of cytosolic calcium ion concentration homophilic cell adhesion via plasma membrane adhesion molecules modulation of chemical synaptic transmission synapse organization regulation of receptor localization to synapse excitatory synapse assembly positive regulation of protein phosphorylation positive regulation of fibroblast growth factor receptor signaling pathway long-term potentiation axon guidance dendrite self-avoidance trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission negative regulation of cytokine production cellular calcium ion homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27020 n/a Ensembl ENSG00000156642 n/a UniProt Q9Y639 n/a RefSeq (mRNA) NM_001161363 NM_001161364 NM_012428 NM_017455 n/a RefSeq (protein) NP_001154835 NP_001154836 NP_036560 NP_059429 n/a Location (UCSC) Chr 15: 73.56 – 73.63 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Neuroplastin is a protein that in humans is encoded by the NPTN gene. ^{[3] [4] [5]}

Neuroplastin is a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. The alpha and beta transcripts show differential localization within the brain. ^[5]

In 2014, in a study led by Dr. Sylvane Desrivières, of King's College London's Institute of Psychiatry found that "teenagers who had a highly functioning NPTN gene performed better in intelligence tests" ^{[6] [7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000156642 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (June 1996). "A "double adaptor" method for improved shotgun library construction". Anal Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
4. Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (June 1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.
5. "Entrez Gene: NPTN neuroplastin".
6. Is intelligence written in the genes?
7. Researchers Find Gene that Links Grey Matter with Intelligence
8. Single nucleotide polymorphism in the neuroplastin locus associates with cortical thickness and intellectual ability in adolescents

Further reading

• Langnaese K, Beesley PW, Gundelfinger ED (1997). "Synaptic membrane glycoproteins gp65 and gp55 are new members of the immunoglobulin superfamily". J. Biol. Chem. 272 (2): 821–7. doi: 10.1074/jbc.272.2.821 . PMID   8995369.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Saito A, Fujikura-Ouchi Y, Kuramasu A, et al. (2007). "Association study of putative promoter polymorphisms in the neuroplastin gene and schizophrenia". Neurosci. Lett. 411 (3): 168–73. doi:10.1016/j.neulet.2006.08.042. PMID   17123723. S2CID   36492996.
• Bernstein HG, Smalla KH, Bogerts B, et al. (2007). "The immunolocalization of the synaptic glycoprotein neuroplastin differs substantially between the human and the rodent brain". Brain Res. 1134 (1): 107–12. doi:10.1016/j.brainres.2006.11.090. PMID   17196182. S2CID   31095277.