NUCKS1

NUCKS1
Identifiers
Aliases	NUCKS1 , NUCKS, JC7, nuclear casein kinase and cyclin-dependent kinase substrate 1, nuclear casein kinase and cyclin dependent kinase substrate 1
External IDs	OMIM: 611912; MGI: 1934811; HomoloGene: 23377; GeneCards: NUCKS1; OMA:NUCKS1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 205,712,822 bp [1] End 205,750,182 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 E4 Start 131,838,272 bp [2] End 131,864,059 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii parietal pleura internal globus pallidus germinal epithelium visceral pleura middle temporal gyrus external globus pallidus pars reticulata seminal vesicula tibia Top expressed in Rostral migratory stream primitive streak ciliary body abdominal wall migratory enteric neural crest cell dermis Gonadal ridge renal corpuscle internal carotid artery vas deferens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding chromatin binding double-stranded DNA binding single-stranded DNA binding RNA binding Cellular component cytoplasm nucleus chromatin nucleolus Biological process positive regulation of insulin receptor signaling pathway transcription by RNA polymerase II glucose homeostasis positive regulation of transcription by RNA polymerase II interstrand cross-link repair regulation of DNA strand elongation cellular response to X-ray regulation of DNA replication gene conversion double-strand break repair via homologous recombination regulation of transcription by RNA polymerase II replication fork processing cellular glucose homeostasis chromatin organization regulation of insulin receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64710 98415 Ensembl ENSG00000069275 ENSMUSG00000026434 UniProt Q9H1E3 Q80XU3 RefSeq (mRNA) NM_022731 NM_001145804 NM_175294 RefSeq (protein) NP_073568 NP_001139276 NP_780503 Location (UCSC) Chr 1: 205.71 – 205.75 Mb Chr 1: 131.84 – 131.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear ubiquitous casein and cyclin-dependent kinases substrate is a protein that in humans is encoded by the NUCKS1 gene. ^{[5] [6]}

References

1. GRCh38: Ensembl release 89: ENSG00000069275 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026434 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ostvold AC, Norum JH, Mathiesen S, Wanvik B, Sefland I, Grundt K (Apr 2001). "Molecular cloning of a mammalian nuclear phosphoprotein NUCKS, which serves as a substrate for Cdk1 in vivo". Eur J Biochem. 268 (8): 2430–40. doi: 10.1046/j.1432-1327.2001.02120.x . PMID   11298763.
6. "Entrez Gene: NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Thompson HG, Harris JW, Wold BJ, et al. (2003). "Identification and confirmation of a module of coexpressed genes". Genome Res. 12 (10): 1517–22. doi:10.1101/gr.418402. PMC   187523 . PMID   12368243.
• Grundt K, Skjeldal L, Anthonsen HW, et al. (2002). "A putative DNA-binding domain in the NUCKS protein". Arch. Biochem. Biophys. 407 (2): 168–75. doi:10.1016/S0003-9861(02)00513-1. PMID   12413487.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Grundt K, Haga IV, Aleporou-Marinou V, et al. (2004). "Characterisation of the NUCKS gene on human chromosome 1q32.1 and the presence of a homologous gene in different species". Biochem. Biophys. Res. Commun. 323 (3): 796–801. doi:10.1016/j.bbrc.2004.08.153. PMID   15381070.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gevaert K, Staes A, Van Damme J, et al. (2006). "Global phosphoproteome analysis on human HepG2 hepatocytes using reversed-phase diagonal LC". Proteomics. 5 (14): 3589–99. doi:10.1002/pmic.200401217. PMID   16097034. S2CID   895879.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Grundt K, Haga IV, Huitfeldt HS, Ostvold AC (2007). "Identification and characterization of two putative nuclear localization signals (NLS) in the DNA-binding protein NUCKS". Biochim. Biophys. Acta. 1773 (9): 1398–406. doi:10.1016/j.bbamcr.2007.05.013. PMID   17604136.