NUDC

NUDC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3QOR
Identifiers
Aliases	NUDC , HMNPD011, nudC nuclear distribution protein, nuclear distribution C, dynein complex regulator
External IDs	OMIM: 610325; MGI: 106014; HomoloGene: 4812; GeneCards: NUDC; OMA:NUDC - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p36.11 Start 26,900,238 bp [1] End 26,946,871 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.3 Start 133,259,853 bp [2] End 133,273,307 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii right uterine tube right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex right frontal lobe anterior cingulate cortex olfactory zone of nasal mucosa internal globus pallidus Top expressed in yolk sac embryo embryo dentate gyrus of hippocampal formation granule cell ventricular zone zygote superior frontal gyrus neural layer of retina primary visual cortex tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cadherin binding unfolded protein binding Cellular component cytoplasm microtubule cytoskeleton nucleus nucleoplasm cytosol Biological process multicellular organism development cell division cell cycle cell population proliferation sister chromatid cohesion protein folding developmental process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10726 18221 Ensembl ENSG00000090273 ENSMUSG00000028851 UniProt Q9Y266 O35685 RefSeq (mRNA) NM_006600 NM_010948 RefSeq (protein) NP_006591 NP_035078 Location (UCSC) Chr 1: 26.9 – 26.95 Mb Chr 4: 133.26 – 133.27 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nuclear migration protein nudC is a protein that in humans is encoded by the NUDC gene. ^[5]

Interactions

NUDC has been shown to interact with PLK1 ^[6] and PAFAH1B1. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000090273 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028851 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: NUDC nuclear distribution gene C homolog (A. nidulans)".
6. Zhou T, Aumais JP, Liu X, Yu-Lee LY, Erikson RL (Jul 2003). "A role for Plk1 phosphorylation of NudC in cytokinesis". Developmental Cell. 5 (1): 127–38. doi: 10.1016/S1534-5807(03)00186-2 . PMID   12852857.
7. Morris SM, Albrecht U, Reiner O, Eichele G, Yu-Lee LY (May 1998). "The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC". Current Biology. 8 (10): 603–6. Bibcode:1998CBio....8..603M. doi: 10.1016/S0960-9822(98)70232-5 . PMID   9601647.

Further reading

• Morris SM, Albrecht U, Reiner O, Eichele G, Yu-Lee LY (May 1998). "The lissencephaly gene product Lis1, a protein involved in neuronal migration, interacts with a nuclear movement protein, NudC". Current Biology. 8 (10): 603–6. Bibcode:1998CBio....8..603M. doi: 10.1016/S0960-9822(98)70232-5 . PMID   9601647.
• Miller BA, Zhang MY, Gocke CD, De Souza C, Osmani AH, Lynch C, Davies J, Bell L, Osmani SA (Apr 1999). "A homolog of the fungal nuclear migration gene nudC is involved in normal and malignant human hematopoiesis". Experimental Hematology. 27 (4): 742–50. doi: 10.1016/S0301-472X(98)00074-5 . PMID   10210332.
• Matsumoto N, Ledbetter DH (Jun 1999). "Molecular cloning and characterization of the human NUDC gene". Human Genetics. 104 (6): 498–504. doi:10.1007/s004390050994. PMID   10453739. S2CID   6596735.
• Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Aumais JP, Tunstead JR, McNeil RS, Schaar BT, McConnell SK, Lin SH, Clark GD, Yu-Lee LY (Dec 2001). "NudC associates with Lis1 and the dynein motor at the leading pole of neurons". The Journal of Neuroscience. 21 (24): RC187. doi:10.1523/JNEUROSCI.21-24-j0002.2001. PMC   6763039 . PMID   11734602.
• Aumais JP, Williams SN, Luo W, Nishino M, Caldwell KA, Caldwell GA, Lin SH, Yu-Lee LY (May 2003). "Role for NudC, a dynein-associated nuclear movement protein, in mitosis and cytokinesis". Journal of Cell Science. 116 (Pt 10): 1991–2003. doi:10.1242/jcs.00412. PMID   12679384. S2CID   186972.
• Zhou T, Aumais JP, Liu X, Yu-Lee LY, Erikson RL (Jul 2003). "A role for Plk1 phosphorylation of NudC in cytokinesis". Developmental Cell. 5 (1): 127–38. doi: 10.1016/S1534-5807(03)00186-2 . PMID   12852857.
• Lin SH, Nishino M, Luo W, Aumais JP, Galfione M, Kuang J, Yu-Lee LY (Apr 2004). "Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein". Oncogene. 23 (14): 2499–506. doi: 10.1038/sj.onc.1207343 . PMID   14676831.
• Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Pan RM, Yang Y, Wei MX, Yu XB, Ge YC, Xu P (Nov 2005). "A microtubule associated protein (hNUDC) binds to the extracellular domain of thrombopoietin receptor (Mpl)". Journal of Cellular Biochemistry. 96 (4): 741–50. doi:10.1002/jcb.20573. PMID   16088917. S2CID   426115.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Nishino M, Kurasawa Y, Evans R, Lin SH, Brinkley BR, Yu-Lee LY (Jul 2006). "NudC is required for Plk1 targeting to the kinetochore and chromosome congression". Current Biology. 16 (14): 1414–21. Bibcode:2006CBio...16.1414N. doi: 10.1016/j.cub.2006.05.052 . PMID   16860740. S2CID   14293580.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.