NUDT11

NUDT11
Identifiers
Aliases	NUDT11 , APS1, ASP1, DIPP3b, DIPP3beta, hDIPP3beta, nudix hydrolase 11
External IDs	OMIM: 300528; MGI: 1930957; HomoloGene: 86995; GeneCards: NUDT11; OMA:NUDT11 - orthologs
EC number	3.6.1.60
Gene location (Human)
Chr.	X chromosome (human)
End	51,496,592 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	5,967,164 bp
RNA expression pattern
	Top expressed in
	orbitofrontal cortex; ; Brodmann area 23; ; embryo; ; ganglionic eminence; ; middle temporal gyrus; ; gonad; ; right testis; ; superior frontal gyrus; ; oocyte; ; secondary oocyte;
	Top expressed in
	arcuate nucleus; ; dorsomedial hypothalamic nucleus; ; median eminence; ; ventromedial nucleus; ; suprachiasmatic nucleus; ; paraventricular nucleus of hypothalamus; ; barrel cortex; ; supraoptic nucleus; ; yolk sac; ; ventral tegmental area;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	inositol-3-diphosphate-1,2,4,5,6-pentakisphosphate diphosphatase activity ; inositol diphosphate tetrakisphosphate diphosphatase activity ; inositol-3,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity ; hydrolase activity ; metal ion binding ; inositol-5-diphosphate-1,2,3,4,6-pentakisphosphate diphosphatase activity ; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 1-diphosphatase activity ; inositol-1,5-bisdiphosphate-2,3,4,6-tetrakisphosphate 5-diphosphatase activity ; inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity ; inositol diphosphate pentakisphosphate diphosphatase activity ; inositol bisdiphosphate tetrakisphosphate diphosphatase activity ; endopolyphosphatase activity ; diphosphoinositol-polyphosphate diphosphatase activity ; bis(5'-adenosyl)-hexaphosphatase activity ; bis(5'-adenosyl)-pentaphosphatase activity ; m7G(5')pppN diphosphatase activity ;
Cellular component	intracellular anatomical structure ; nucleus ; cytoplasm ; cytosol ;
Biological process	inositol phosphate metabolic process ; diphosphoinositol polyphosphate metabolic process ; diadenosine pentaphosphate catabolic process ; diadenosine hexaphosphate catabolic process ; adenosine 5'-(hexahydrogen pentaphosphate) catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	55190
	58242
	ENSG00000196368
	ENSMUSG00000073295
	Q96G61
	P0C027 ; P0C028
	NM_018159
	NM_021431
	NP_060629
	NP_001026834 ; NP_067406 ; NP_067406
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 04, 2024

Diphosphoinositol polyphosphate phosphohydrolase 3-beta is an enzyme that in humans is encoded by the NUDT11 gene.^[5]^[6]

NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates.^[6]

Related Research Articles

Cleavage and polyadenylation specificity factor subunit 5 (CPSF5) is an enzyme that in humans is encoded by the NUDT21 gene. It belongs to the Nudix family of hydrolases.

GPI transamidase component PIG-T is an enzyme that in humans is encoded by the PIGT gene.

Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical] is an enzyme that in humans is encoded by the NUDT2 gene.

Spindlin-1 is a protein that in humans is encoded by the SPIN1 gene.

tRNA-nucleotidyltransferase 1, is an enzyme that in humans is encoded by the TRNT1 gene. This enzyme adds the nucleotide sequence CCA to the 3' end of tRNA, using ATP and CTP as substrates. The sequence creates the binding site for an amino acid.

N-terminal acetyltransferase B complex catalytic subunit NAT5 is an enzyme that in humans is encoded by the NAT5 gene.

RNA exonuclease 4 is an enzyme that in humans is encoded by the REXO4 gene.

NUAK family SNF1-like kinase 2 also known as SNF1/AMP kinase-related kinase (SNARK) is an enzyme that in humans is encoded by the NUAK2 gene. Its deficiency in humans causes anencephaly, a severe form of anterior neural tube defect that curtails brain development.

ADP-ribose pyrophosphatase, mitochondrial is an enzyme that in humans is encoded by the NUDT9 gene.

Ubiquitin-like protein 3 is a protein that in humans is encoded by the UBL3 gene.

Ubiquitin carboxyl-terminal hydrolase 44 is an enzyme that in humans is encoded by the USP44 gene.

Diphosphoinositol polyphosphate phosphohydrolase 2 is an enzyme that in humans is encoded by the NUDT4 gene.

Zinc transporter 7 is a protein that in humans is encoded by the SLC30A7 gene.

Fumarylacetoacetate hydrolase domain-containing protein 1, also known as FLJ36880 protein, is an enzyme that in humans is encoded by the FAHD1 gene on chromosome 16.

E3 ubiquitin-protein ligase ZNRF1 is an enzyme that in humans is encoded by the ZNRF1 gene.

Diphosphoinositol polyphosphate phosphohydrolase 1 is an enzyme that in humans is encoded by the NUDT3 gene.

Peroxisomal NADH pyrophosphatase NUDT12 is an enzyme that in humans is encoded by the NUDT12 gene.

ADP-sugar pyrophosphatase is an enzyme that in humans is encoded by the NUDT5 gene.

Phosphatidylinositol 4,5-bisphosphate 5-phosphatase A is an enzyme that in humans is encoded by the INPP5J gene.

NudC domain-containing protein 2 is a protein that in humans is encoded by the NUDCD2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000196368 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073295 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hidaka K, Caffrey JJ, Hua L, Zhang T, Falck JR, Nickel GC, Carrel L, Barnes LD, Shears SB (Sep 2002). "An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase". J Biol Chem. 277 (36): 32730–8. doi: 10.1074/jbc.M205476200 . PMID 12105228.
1 2 "Entrez Gene: NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11".

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948 . PMID 11076863.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732 . PMID 11256614.
Leslie NR, McLennan AG, Safrany ST (2002). "Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases". BMC Biochem. 3: 20. doi: 10.1186/1471-2091-3-20 . PMC 117780 . PMID 12121577.
Fisher DI, Safrany ST, Strike P, et al. (2003). "Nudix hydrolases that degrade dinucleoside and diphosphoinositol polyphosphates also have 5-phosphoribosyl 1-pyrophosphate (PRPP) pyrophosphatase activity that generates the glycolytic activator ribose 1,5-bisphosphate". J. Biol. Chem. 277 (49): 47313–7. doi: 10.1074/jbc.M209795200 . PMID 12370170.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930 . PMID 15489336.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome". Nature. 434 (7031): 325–37. Bibcode:2005Natur.434..325R. doi:10.1038/nature03440. PMC 2665286 . PMID 15772651.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501 . PMID 16381901.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000196368 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000073295 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12105228-5] Hidaka K, Caffrey JJ, Hua L, Zhang T, Falck JR, Nickel GC, Carrel L, Barnes LD, Shears SB (Sep 2002). "An adjacent pair of human NUDT genes on chromosome X are preferentially expressed in testis and encode two new isoforms of diphosphoinositol polyphosphate phosphohydrolase". J Biol Chem. 277 (36): 32730–8. doi: 10.1074/jbc.M205476200 . PMID 12105228.

[entrez-6] 1 2 "Entrez Gene: NUDT11 nudix (nucleoside diphosphate linked moiety X)-type motif 11".

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NUDT11

Related Research Articles

References

Further reading