NUDT21

Last updated
NUDT21
Protein NUDT21 PDB 2cl3.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NUDT21 , CFIM25, CPSF5, nudix hydrolase 21
External IDs OMIM: 604978 MGI: 1915469 HomoloGene: 5090 GeneCards: NUDT21
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007006

NM_026623

RefSeq (protein)

NP_008937

NP_080899

Location (UCSC) Chr 16: 56.43 – 56.45 Mb Chr 8: 94.74 – 94.76 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cleavage and polyadenylation specificity factor subunit 5 (CPSF5) is an enzyme that in humans is encoded by the NUDT21 gene. [5] [6] It belongs to the Nudix family of hydrolases.

The protein encoded by this gene is one subunit of the cleavage factor Im complex required for 3' RNA cleavage and polyadenylation processing. [7] The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. This gene encodes the 25kD subunit of the protein complex, which is composed of four polypeptides. [6]

Related Research Articles

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5'-3' Exoribonuclease 2 (XRN2) also known as Dhm1-like protein is an exoribonuclease enzyme that in humans is encoded by the XRN2 gene.

<span class="mw-page-title-main">SFRS3</span>

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<span class="mw-page-title-main">CSTF2</span> Protein-coding gene in the species Homo sapiens

Cleavage stimulation factor 64 kDa subunit is a protein that in humans is encoded by the CSTF2 gene.

<span class="mw-page-title-main">CPSF2</span> Protein-coding gene in the species Homo sapiens

Cleavage and polyadenylation specificity factor subunit 2 is a protein that in humans is encoded by the CPSF2 gene.

<span class="mw-page-title-main">CPSF1</span> Protein-coding gene in the species Homo sapiens

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.

<span class="mw-page-title-main">PAPOLA</span>

Poly(A) polymerase alpha is an enzyme that in humans is encoded by the PAPOLA gene.

<span class="mw-page-title-main">CSTF1</span> Protein-coding gene in the species Homo sapiens

Cleavage stimulation factor 50 kDa subunit is a protein that in humans is encoded by the CSTF1 gene.

<span class="mw-page-title-main">CSTF3</span> Protein-coding gene in the species Homo sapiens

Cleavage stimulation factor 77 kDa subunit is a protein that in humans is encoded by the CSTF3 gene.

<span class="mw-page-title-main">CSTF2T</span> Protein-coding gene in the species Homo sapiens

Cleavage stimulation factor 64 kDa subunit, tau variant is a protein that in humans is encoded by the CSTF2T gene.

<span class="mw-page-title-main">60S ribosomal protein L36</span> Protein-coding gene in the species Homo sapiens

60S ribosomal protein L36 is a protein that in humans is encoded by the RPL36 gene.

<span class="mw-page-title-main">CPSF3</span>

Cleavage and polyadenylation specificity factor subunit 3 is a protein that in humans is encoded by the CPSF3 gene.

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60S ribosomal protein L24 is a protein that in humans is encoded by the RPL24 gene.

<span class="mw-page-title-main">60S ribosomal protein L8</span> Protein-coding gene in the species Homo sapiens

60S ribosomal protein L8 is a protein that in humans is encoded by the RPL8 gene.

<span class="mw-page-title-main">40S ribosomal protein S20</span> Protein-coding gene in the species Homo sapiens

40S ribosomal protein S20 is a protein that in humans is encoded by the RPS20 gene.

<span class="mw-page-title-main">CPSF4</span> Protein-coding gene in the species Homo sapiens

Cleavage and polyadenylation specificity factor subunit 4 is a protein that in humans is encoded by the CPSF4 gene.

<span class="mw-page-title-main">CPSF6</span>

Cleavage and polyadenylation specificity factor subunit 6 is a protein that in humans is encoded by the CPSF6 gene.

<span class="mw-page-title-main">40S ribosomal protein S28</span> Protein-coding gene in the species Homo sapiens

40S ribosomal protein S28 is a protein that in humans is encoded by the RPS28 gene.

<span class="mw-page-title-main">INTS11</span> Protein-coding gene in the species Homo sapiens

Integrator complex subunit 11 is a protein that in humans is encoded by the CPSF3L gene.

<span class="mw-page-title-main">Probable ribosome biogenesis protein RLP24</span>

Probable ribosome biogenesis protein RLP24 is a protein that in humans is encoded by the RSL24D1 gene.

<span class="mw-page-title-main">CPSF7</span>

Cleavage and polyadenylation specificity factor subunit 7 is a protein that in humans is encoded by the CPSF7 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000167005 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031754 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ruegsegger U, Blank D, Keller W (Jul 1998). "Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits". Mol Cell. 1 (2): 243–53. doi: 10.1016/S1097-2765(00)80025-8 . PMID   9659921.
  6. 1 2 "Entrez Gene: NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21".
  7. Hardy, J. G.; Norbury, C. J. (15 August 2016). "Cleavage factor Im (CFIm) as a regulator of alternative polyadenylation". Biochemical Society Transactions. 44 (4): 1051–1057. doi:10.1042/BST20160078. PMID   27528751. S2CID   206156045.

Further reading