NUDT6

NUDT6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FXT, 3H95
Identifiers
Aliases	NUDT6 , ASFGF2, FGF-AS, FGF2AS, GFG-1, GFG1, nudix hydrolase 6
External IDs	OMIM: 606261; MGI: 2387618; HomoloGene: 31425; GeneCards: NUDT6; OMA:NUDT6 - orthologs
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q28.1 Start 122,888,697 bp [1] End 122,922,968 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 B Start 37,459,059 bp [2] End 37,474,360 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii internal globus pallidus right lobe of liver germinal epithelium oocyte left ventricle right adrenal gland right adrenal cortex right ventricle left adrenal gland Top expressed in interventricular septum aortic valve ascending aorta right kidney muscle of thigh proximal tubule masseter muscle myocardium of ventricle skeletal muscle tissue sternocleidomastoid muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function growth factor activity hydrolase activity NADH pyrophosphatase activity ADP-ribose diphosphatase activity NAD binding Cellular component cytoplasm mitochondrion nucleus cellular component Biological process regulation of signaling receptor activity biological process negative regulation of cell population proliferation negative regulation of cell cycle Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11162 229228 Ensembl ENSG00000170917 ENSMUSG00000050174 UniProt P53370 Q8CH40 RefSeq (mRNA) NM_198041 NM_007083 NM_001291044 NM_153561 RefSeq (protein) NP_009014 NP_932158 NP_001277973 NP_705789 Location (UCSC) Chr 4: 122.89 – 122.92 Mb Chr 3: 37.46 – 37.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene. ^{[5] [6] [7]}

FGF2 (MIM 134920) is a highly conserved, multifunctional heparin-binding growth factor involved in neuroectoderm development, angiogenesis, and wound healing.

Elevated levels of FGF2 are associated with proliferation of smooth muscle in atherosclerosis and with proliferation of tumors. The FGF2 antisense gene, NUDT6, may regulate FGF2 expression.[supplied by OMIM] ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000170917 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050174 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Murphy PR, Knee RS (Jan 1995). "Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene". Mol Endocrinol. 8 (7): 852–9. doi: 10.1210/mend.8.7.7984147 . PMID   7984147.
6. Gagnon ML, Moy GK, Klagsbrun M (Apr 1999). "Characterization of the promoter for the human antisense fibroblast growth factor-2 gene; regulation by Ets in Jurkat T cells". J Cell Biochem. 72 (4): 492–506. doi:10.1002/(SICI)1097-4644(19990315)72:4<492::AID-JCB5>3.0.CO;2-H. PMID   10022609. S2CID   28384265.
7. "Entrez Gene: NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6".

Further reading

• Knee RS, Pitcher SE, Murphy PR (1995). "Basic fibroblast growth factor sense (FGF) and antisense (gfg) RNA transcripts are expressed in unfertilized human oocytes and in differentiated adult tissues". Biochem. Biophys. Res. Commun. 205 (1): 577–83. doi:10.1006/bbrc.1994.2704. PMID   7999082.
• Li AW, Too CK, Knee R, et al. (1998). "FGF-2 antisense RNA encodes a nuclear protein with MutT-like antimutator activity". Mol. Cell. Endocrinol. 133 (2): 177–82. doi:10.1016/S0303-7207(97)00148-2. PMID   9406864. S2CID   43782586.
• Asa SL, Ramyar L, Murphy PR, et al. (2001). "The endogenous fibroblast growth factor-2 antisense gene product regulates pituitary cell growth and hormone production". Mol. Endocrinol. 15 (4): 589–99. doi: 10.1210/me.15.4.589 . PMID   11266510.
• Duplan SM, Théorêt Y, Kenigsberg RL (2002). "Antitumor activity of fibroblast growth factors (FGFs) for medulloblastoma may correlate with FGF receptor expression and tumor variant". Clin. Cancer Res. 8 (1): 246–57. PMID   11801566.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Sheng Z, Lewis JA, Chirico WJ (2004). "Nuclear and nucleolar localization of 18-kDa fibroblast growth factor-2 is controlled by C-terminal signals". J. Biol. Chem. 279 (38): 40153–60. doi: 10.1074/jbc.M400123200 . PMID   15247275.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Vasilescu J, Zweitzig DR, Denis NJ, et al. (2007). "The proteomic reactor facilitates the analysis of affinity-purified proteins by mass spectrometry: application for identifying ubiquitinated proteins in human cells". J. Proteome Res. 6 (1): 298–305. CiteSeerX   10.1.1.401.4220 . doi:10.1021/pr060438j. PMID   17203973.
• Pezzatini S, Morbidelli L, Solito R, et al. (2007). "Nanostructured HA crystals up-regulate FGF-2 expression and activity in microvascular endothelium promoting angiogenesis". Bone. 41 (4): 523–34. doi:10.1016/j.bone.2007.06.016. PMID   17681892.