NUF2

Last updated

NUF2
Protein NUF2 PDB 2VE7.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases NUF2 , CDCA1, CT106, NUF2R, NDC80 kinetochore complex component, NDC80 kinetochore complex component NUF2 component of NDC80 kinetochore complex
External IDs OMIM: 611772; MGI: 1914227; HomoloGene: 40205; GeneCards: NUF2; OMA:NUF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_031423
NM_145697

NM_023284
NM_001355159

RefSeq (protein)

NP_113611
NP_663735

NP_075773
NP_001342088

Location (UCSC) Chr 1: 163.27 – 163.36 Mb Chr 1: 169.33 – 169.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Kinetochore protein Nuf2 is a protein that in humans is encoded by the NUF2 gene. [5] [6] [7]

This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation.

The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000143228 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000026683 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Wigge PA, Kilmartin JV (Mar 2001). "The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation". J Cell Biol. 152 (2): 349–60. doi:10.1083/jcb.152.2.349. PMC   2199619 . PMID   11266451.
  6. Nabetani A, Koujin T, Tsutsumi C, Haraguchi T, Hiraoka Y (Oct 2001). "A conserved protein, Nuf2, is implicated in connecting the centromere to the spindle during chromosome segregation: a link between the kinetochore function and the spindle checkpoint". Chromosoma. 110 (5): 322–34. doi:10.1007/s004120100153. PMID   11685532. S2CID   22443613.
  7. 1 2 "Entrez Gene: NUF2 NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)".

Further reading